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Title
Succination inactivates gasdermin D and blocks pyroptosis
Authors
Keywords
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Journal
SCIENCE
Volume -, Issue -, Pages eabb9818
Publisher
American Association for the Advancement of Science (AAAS)
Online
2020-08-21
DOI
10.1126/science.abb9818
References
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Related references
Note: Only part of the references are listed.- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- A chemoproteomic portrait of the oncometabolite fumarate
- (2019) Rhushikesh A. Kulkarni et al. Nature Chemical Biology
- Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
- (2019) Corey Rogers et al. Nature Communications
- Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
- (2019) Ranjan Dutta et al. Jove-Journal of Visualized Experiments
- Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis
- (2019) Sheng Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
- (2019) Shan-Ting Liao et al. Nature Communications
- GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever
- (2018) Apurva Kanneganti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
- (2018) Brienne A. McKenzie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
- (2018) Michael D. Kornberg et al. SCIENCE
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
- (2018) Monika Bambouskova et al. NATURE
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
- (2016) Anju Singh et al. ACS Chemical Biology
- Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
- (2016) Vicky Lampropoulou et al. Cell Metabolism
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice
- (2011) Jae Jin Chae et al. IMMUNITY
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