Article
Cell Biology
Yu Zhang, Ruicheng Zhang, Xiaohu Han
Summary: Disulfiram, as an inhibitor of GSDMD, can effectively inhibit cell pyroptosis, inflammation, and fibrosis in renal fibrosis. However, it does not provide significant prevention if the cells have already undergone pyroptosis. In vivo experiments have further confirmed its inhibitory effect on renal fibrosis injury.
INFLAMMATION RESEARCH
(2021)
Article
Immunology
Youfa Zhou, Yanting Zhang, Hongwei Wang, Xiangnan Zhang, Yeru Chen, Gang Chen
Summary: This study aimed to examine the effect of pyroptosis on sevoflurane-induced cognitive impairment in aged mice. The results showed that sevoflurane induced pyroptosis in the hippocampus and led to cognitive impairment. Inhibition of pyroptosis and scavenging of reactive oxygen species (ROS) may be potential approaches to alleviate sevoflurane-induced neurocognitive dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yiteng Lu, Ye Sun, Yong Peng, Xiaoqiang Zhao, Danjie Wang, Tongtong Zhang, Fang Qian, Jun Wang
Summary: The role of Gasdermin D (GSDMD) in atopic dermatitis (AD) was investigated. Through analysis of gene expression data and mouse experiments, it was found that GSDMD deletion and inhibition can alleviate symptoms of AD, such as reduced skin thickness, scarring, and scratching behavior. Furthermore, GSDMD deletion and inhibition also resulted in reduced infiltration of inflammatory cells, decreased epidermal thickness, and lower levels of IL-18 and IL-18.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Neurosciences
Teng Wan, Xiaoyu Li, Mingyuan Fu, Xiaoyu Gao, Peiling Li, Weiming Guo
Summary: This article provides a timely review of recent findings on the activation and regulation of pyroptosis in relation to depression, highlighting the important role of neuroinflammation in the pathogenesis of depression. It also discusses the therapeutic effects of chemical agents and natural products by modulating pyroptosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Xiaoyu Ma, Yajuan Li, Wenxiang Shen, Ayodele Olaolu Oladejo, Jie Yang, Wei Jiang, Bereket Habte Imam, Xiaohu Wu, Xuezhi Ding, Ying Yang, Shengyi Wang, Zuoting Yan
Summary: Pyroptosis is a highly inflammatory form of programmed cell death triggered by pro-inflammatory signals, characterized by cell swelling and release of cytokines. In LPS-induced inflammation, the mechanism of endometrial epithelial cell pyroptosis remains unclear, possibly involving specific inflammasome cascade pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Yanyan Li, Junda Wang, Dan Huang, Chao Yu
Summary: The study found that baicalin can alleviate iohexol-induced pyroptosis in HK-2 cells by regulating the NLRP3 inflammasome pathway and inhibiting the changes in relevant indicators.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Xuezhi Zhou, Rong Rong, Ganghao Liang, Haibo Li, Mengling You, Zhou Zeng, Haihua Xiao, Dan Ji, Xiao Xia
Summary: Glaucoma is a prominent cause of irreversible vision damage worldwide, but currently there is no effective treatment available. This study identified that overexpression of N-GSDMD protein can lead to pyroptosis in retinal ganglion cells (RGCs). A novel inhibitor called DSF, in combination with Cu(II), was found to significantly inhibit pyroptosis in RGCs. In vivo experiments showed that DSF-NPs+Cu(II) selectively inhibited pyroptosis in RGCs and provided a new therapeutic strategy for acute glaucoma.
Review
Cell Biology
Miao Pan, Ruiqing Tai, Yanrong Liu, Zhuwen Sun, Huan Yuan, Qiong Wu, Yongnian Liu, Chao Sun
Summary: Obesity is characterized by persistent low-level inflammation and insulin resistance, with pyroptosis playing a significant role in the pathogenesis of chronic inflammatory diseases. Targeting pyroptosis-related molecules may offer a new potential therapy for obesity-related inflammatory diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lu Xia, Lu Liu, Yiying Cai, Yiying Zhang, Fangchao Tong, Qiang Wang, Jing Ding, Xin Wang
Summary: The study revealed that GSDMD-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures. Following SE, GSDMD expression increased and GSDMD-N expression was significantly elevated. DMF treatment resulted in decreased SRS, reduced damaged astrocytes, and attenuated expression of inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xueying Li, Jiahe Lin, Yingjie Hua, Jiaoni Gong, Siqi Ding, Yanru Du, Xinshi Wang, Rongyuan Zheng, Huiqin Xu
Summary: The study demonstrated that agmatine affects epileptogenesis and provides neuroprotection by inhibiting neuroinflammation, GSDMD activation, and pyroptosis. The inhibitory effect of agmatine on pyroptosis is mediated through the suppression of the TLR4/MYD88/NF-kappa B/NLRP3 inflammasome pathway, suggesting agmatine as a potential treatment option for epilepsy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Min Feng, Shaoqiang Wei, Shidong Zhang, Ying Yang
Summary: The study found that mangiferin can regulate inflammation and cell pyroptosis through inhibiting the NF-κ B pathway, suppressing inflammatory caspase-mediated pyroptosis cascades, and reducing GSDMD cleavage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jinxiang Wu, Jintao Zhang, Jiping Zhao, Shihong Chen, Tao Zhou, Jianwei Xu
Summary: This study revealed the role of GSDMD-mediated pyroptosis in SAP-associated lung injury, and demonstrated the potential application of disulfiram as a pyroptosis inhibitor in the treatment of SAP.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xin Liu, Yanyan Li, Jie Zhao, Zhihui Hu, Wei Fang, Jin Ke, Wei Li, Xing Long
Summary: This study investigates the role of chondrocyte pyroptosis in temporomandibular joint osteoarthritis (TMJ-OA) and reveals that synovial inflammation-induced chondrocyte pyroptosis promotes cartilage degradation via the ROS and NLRP3 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jing Zhang, Yiqin Dai, Yujing Yang, Jianjiang Xu
Summary: This study found increased pyroptosis in dry eye patients and demonstrated that calcitriol could effectively alleviate hyperosmotic stress-induced corneal epithelial cell damage by inhibiting the NLRP3-ASC-caspase-1-GSDMD pyroptosis pathway. Thus, calcitriol shows promise as a therapeutic agent for dry eye due to its multiple therapeutic targets.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Xiaona Gao, Shuhui Liu, Lei Tan, Chenchen Ding, Wentao Fan, Zhangshan Gao, Mengcong Li, Zhihui Tang, Yuting Wu, Lei Xu, Liping Yan, Yan Luo, Suquan Song
Summary: This study demonstrated that estrogen receptor alpha plays a role in negatively controlling hepatocyte pyroptosis by inhibiting NLRP3 inflammasome activation. Inhibiting pyroptosis was found to alleviate metabolic dysfunction, insulin resistance, and liver injury caused by ER alpha deletion. Additionally, treatment with a phytoestrogen could attenuate high-fat diet-induced liver lipid steatosis and inhibit NLRP3-GSDMD-mediated pyroptosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
