Molecular mechanisms regulating NLRP3 inflammasome activation

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

(2015) Prajwal Gurung et al.   AMERICAN JOURNAL OF PATHOLOGY

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages

(2015) Sung-Soo Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Negative regulation of the inflammasome: keeping inflammation under control

(2015) Gustavo Pedraza-Alva et al.   IMMUNOLOGICAL REVIEWS

Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

(2015) Dan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

(2015) Fahima Madouri et al.   Journal of Molecular Cell Biology

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3

(2014) Patrick M. Giguère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA and β-Hemolysin of Group BStreptococcusInduce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages

(2014) Rahul Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

(2014) Sayaka Ito et al.   ARTHRITIS RESEARCH & THERAPY

Zinc depletion regulates the processing and secretion of IL-1β

(2014) H Summersgill et al.   Cell Death & Disease

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

(2013) Kathy Triantafilou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

(2013) Heriberto Lima Jr. et al.   CELL CYCLE

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

(2013) Joshua Jabaut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The expanding role of NLRs in antiviral immunity

(2013) Christopher Lupfer et al.   IMMUNOLOGICAL REVIEWS

NADPH Oxidase Biology and the Regulation of Tyrosine Kinase Receptor Signaling and Cancer Drug Cytotoxicity

(2013) Rafael Paletta-Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

(2013) Robert van der Burgh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Inflammasome and Host Protection against Bacterial Infection

(2013) Jwa-Jin Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

(2013) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Secreted aspartic proteases ofCandida albicansactivate the NLRP3 inflammasome

(2012) Donatella Pietrella et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway

(2012) J. D. Schilling et al.   JOURNAL OF IMMUNOLOGY

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

TLR Agonists Stimulate Nlrp3-Dependent IL-1  Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

(2012) Y. He et al.   JOURNAL OF IMMUNOLOGY

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

(2012) Clare M. Reynolds et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

(2011) Kristin A. D. Sauter et al.   CANCER BIOLOGY & THERAPY

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

Inflammasome activation via intracellular NLRs triggered by bacterial infection

(2011) Yukiko Koizumi et al.   CELLULAR MICROBIOLOGY

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Xanthine oxidoreductase: A journey from purine metabolism to cardiovascular excitation-contraction coupling

(2011) Amit Agarwal et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Control of antiviral immunity by pattern recognition and the microbiome

(2011) Iris K. Pang et al.   IMMUNOLOGICAL REVIEWS

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

(2011) T. Bergsbaken et al.   JOURNAL OF IMMUNOLOGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Nucleotide-Binding Oligomerization Domain-Like Receptors and Inflammasomes in the Pathogenesis of Non-Microbial Inflammation and Diseases

(2011) D. Randal Mason et al.   Journal of Innate Immunity

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Evaluation of Nod-Like Receptor (NLR) Effector Domain Interactions

(2009) Roland N. Wagner et al.   PLoS One

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE