Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals

Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway

(2022) Fengjie Liu et al.   Cancer Nanotechnology

Anticancer potential of allicin: A review

(2022) Elena Catanzaro et al.   PHARMACOLOGICAL RESEARCH

A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein

(2022) Jia-Qi Lu et al.   Toxins

Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health

(2022) Adriana de Cássia Ortiz et al.   Biomolecules

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

(2022) He Pang et al.   Journal of Bone Oncology

Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway

(2022) Wenpeng Xie et al.   Oxidative Medicine and Cellular Longevity

Tandem fusion of albumin-binding domains promoted soluble expression and stability of recombinant trichosanthin in vitro and in vivo

(2022) ZeFeng Ren et al.   PROTEIN EXPRESSION AND PURIFICATION

Variations of Bioactive Phytochemicals and Antioxidant Capacity of Navel Orange Peel in Response to Different Drying Methods

(2022) Chunling Lai et al.   Antioxidants

The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

(2021) Dr Lakhan Kma et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

(2021) Maojian Chen et al.   Drug Design Development and Therapy

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Extraction, purification, bioactivity and pharmacological effects of capsaicin: a review

(2021) Fengzhang Wang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Role of mTOR Signaling as a Therapeutic Target in Cancer

(2021) Nadezhda V. Popova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties

(2021) Majid Tafrihi et al.   MOLECULES

Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer

(2021) Xiaoye Fan et al.   PHYTOMEDICINE

Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

(2021) Rania F. Zaarour et al.   Cancers

Mutant p53 as a Regulator and Target of Autophagy

(2021) Yong Shi et al.   Frontiers in Oncology

Overview of Piperlongumine Analogues and their Therapeutic Potential

(2021) Peng Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

(2021) Ying-Jun Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Piperlongumine attenuates oxidative stress, inflammatory, and apoptosis through modulating the GLUT‐2/4 and AKT signaling pathway in streptozotocin‐induced diabetic rats

(2021) Ping Xu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: A review

(2021) Yue-Hu Wang   JOURNAL OF ETHNOPHARMACOLOGY

Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis

(2021) Shao-Cheng Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis by inhibiting PINK1/Parkin-dependent mitophagy

(2021) Soon-Kyung Hwang et al.   Journal of Ginseng Research

Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

(2021) Yan Zhang et al.   Aging-US

Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway

(2021) Ke Zhang et al.   CARBOHYDRATE POLYMERS

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats

(2021) Adel T. Osman et al.   FOOD AND CHEMICAL TOXICOLOGY

Baicalin protects LPS-induced blood–brain barrier damage and activates Nrf2-mediated antioxidant stress pathway

(2021) Xin Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer

(2021) Yu He et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

(2021) Lisa M Strong et al.   eLife

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells

(2021) Jingjing Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Celastrol in cancer therapy: Recent developments, challenges and prospects

(2021) Hannah Ying Lim et al.   CANCER LETTERS

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

(2020) Md. Abdul Alim Al‐Bari et al.   Annals of the New York Academy of Sciences

Correction to: ROS and diseases: role in metabolism and energy supply

(2020) Shenshu Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Magnoflorine: A review of its pharmacology, pharmacokinetics and toxicity

(2020) Tong Xu et al.   PHARMACOLOGICAL RESEARCH

Magnoflorine inhibits human gastric cancer progression by inducing autophagy, apoptosis and cell cycle arrest by JNK activation regulated by ROS

(2020) Xiao-li Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

p62 as a therapeutic target for tumor

(2020) Mengmin Tao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Review: antimicrobial properties of allicin used alone or in combination with other medications

(2020) Sulin Choo et al.   FOLIA MICROBIOLOGICA

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

(2020) Dorotea Fracchiolla et al.   JOURNAL OF CELL BIOLOGY

Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases

(2020) Feres José Mocayar Marón et al.   LIFE SCIENCES

Polyphyllin VI Induces Apoptosis and Autophagy via Reactive Oxygen Species Mediated JNK and P38 Activation in Glioma

(2020) Wei Liu et al.   OncoTargets and Therapy

Life, death, and autophagy in cancer: NF-κB turns up everywhere

(2020) Daniela Verzella et al.   Cell Death & Disease

Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways

(2020) Qiang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Recent advances in autophagic machinery: a proteomic perspective

(2020) Xingyun Wu et al.   Expert Review of Proteomics

Neohesperidin attenuates obesity by altering the composition of the gut microbiota in high‐fat diet‐fed mice

(2020) Jun Feng Lu et al.   FASEB JOURNAL

Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways

(2020) Wan‑Ting Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Corrigendum to “Folic acid conjugated curcumin loaded biopolymeric gum acacia microsphere for triple negative breast cancer therapy in invitro and invivo model” [Mater. Sci. Eng. C (2019) 204–216]

(2020) Kunal Pal et al.   Materials Science & Engineering C-Materials for Biological Applications

Diosgenin Attenuates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats: Underlying Mechanisms

(2020) Narges Mahmoudi et al.   NEUROPSYCHOBIOLOGY

Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent

(2020) Surya Kant Tripathi et al.   PHARMACOLOGICAL RESEARCH

Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications

(2020) Khanyisani Ziqubu et al.   PHARMACOLOGICAL RESEARCH

Diosgenin and GSK126 Produce Synergistic Effects on Epithelial–Mesenchymal Transition in Gastric Cancer Cells by Mediating EZH2 via the Rho/ROCK Signaling Pathway

(2020) Shanshan Liu et al.   OncoTargets and Therapy

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

(2020) Wojciech Ornatowski et al.   Redox Biology

16-Hydroxycleroda-3,13-Dien-15,16-Olide Induces Apoptosis in Human Bladder Cancer Cells through Cell Cycle Arrest, Mitochondria ROS Overproduction, and Inactivation of EGFR-Related Signalling Pathways

(2020) Yu-Chi Chen et al.   MOLECULES

Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated Noxa in colorectal cancer

(2020) Qun Zhao et al.   PHYTOMEDICINE

Effects of Supplementary Blue and UV-A LED Lights on Morphology and Phytochemicals of Brassicaceae Baby-Leaves

(2020) Yamin Li et al.   MOLECULES

Polyphyllin VII induces apoptosis and autophagy via mediating H2O2 levels and the JNK pathway in human osteosarcoma U2OS cells

(2020) Xiangde Li et al.   ONCOLOGY REPORTS

Baicalin mediated regulation of key signaling pathways in cancer

(2020) Shilpi Singh et al.   PHARMACOLOGICAL RESEARCH

Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway

(2020) Chaotao Zhang et al.   CELLULAR SIGNALLING

Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways

(2020) Pei Sun et al.   VETERINARY MICROBIOLOGY

Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain

(2020) Vipin Arora et al.   PHARMACOLOGY & THERAPEUTICS

PP2C phosphatases promote autophagy by dephosphorylation of the Atg1 complex

(2019) Gonen Memisoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Metabolic–Redox Circuits for Cancer Therapy

(2019) Kui Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bioactive Compounds of Food: Their Role in the Prevention and Treatment of Diseases

(2019) Anderson Junger Teodoro   Oxidative Medicine and Cellular Longevity

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis

(2019) Vrushank Bhatt et al.   GENES & DEVELOPMENT

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

(2019) Xihong Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

(2019) Marco Cordani et al.   Oxidative Medicine and Cellular Longevity

Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells

(2019) Xing Kang et al.   Artificial Cells Nanomedicine and Biotechnology

Autophagy

(2019) Thomas Wollert   CURRENT BIOLOGY

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Progressive study of effects of erianin on anticancer activity

(2019) Yuying Zhang et al.   OncoTargets and Therapy

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis

(2019) Ming-yong Li et al.   Cell Death & Disease

Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification

(2019) Praveen Anand et al.   Journal of Pain Research

Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway

(2019) Zhigang Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Pristimerin Induces Autophagy‐Mediated Cell Death in K562 Cells through the ROS/JNK Signaling Pathway

(2019) Yingxiang Liu et al.   CHEMISTRY & BIODIVERSITY

An update on PTEN modulators – a patent review

(2019) Chandra S. Boosani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer

(2019) Jin-Feng Teng et al.   PHARMACOLOGICAL RESEARCH

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation

(2019) Yong-Liang Yuan et al.   Drug Design Development and Therapy

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

(2019) Dejiang Pang et al.   Oxidative Medicine and Cellular Longevity

Curcumin and Cancer

(2019) Giordano et al.   Nutrients

Inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive Oxygen Species (ROS) Production, and Autophagy Induction

(2019) Yongqing Han et al.   MEDICAL SCIENCE MONITOR

Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells

(2019) Wei Yan et al.   Journal of Advanced Research

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

(2019) Tian Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-cancer effects of Polyphyllin I: An update in 5 years

(2019) Ye Tian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Regulation of autophagy by canonical and non-canonical ER stress responses

(2019) Monika Bhardwaj et al.   SEMINARS IN CANCER BIOLOGY

Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling

(2019) Qun Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS

(2018) Yong-Qiang Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer

(2018) Bei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemotherapy medication errors

(2018) Saul N Weingart et al.   LANCET ONCOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

(2018) Gautam Sethi et al.   Nutrients

Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

(2018) Pei-Feng Liu et al.   Theranostics

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

(2018) Padmanaban Mohanan et al.   Journal of Ginseng Research

mTOR Pathways in Cancer and Autophagy

(2018) Mathieu Paquette et al.   Cancers

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy

(2018) Israel C. Nnah et al.   Autophagy

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

(2018) Wei-Wei Shi et al.   Toxins

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

(2017) Yingli He et al.   JOURNAL OF CELL BIOLOGY

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Autophagy Receptors and Neurodegenerative Diseases

(2017) Zhiqiang Deng et al.   TRENDS IN CELL BIOLOGY

Ultrasound-promoted copper-catalyzed synthesis of bis-arylselanyl chrysin derivatives with boosted antioxidant and anticancer activities

(2017) Sergio F. Fonseca et al.   ULTRASONICS SONOCHEMISTRY

Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

(2017) Xianjun Yu et al.   Oncotarget

Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways

(2017) Lu Ji et al.   Oncotarget

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

(2017) Renuka Mani et al.   PHYTOCHEMISTRY

Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species

(2017) Mingyue Li et al.   Scientific Reports

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice

(2016) Carlos Borges Filho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes

(2016) Hayashi Yamamoto et al.   DEVELOPMENTAL CELL

Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress‐induced autophagy

(2016) Satoru Torii et al.   EMBO REPORTS

Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways

(2016) Yashi Mi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

(2016) Bin Wei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Capsaicin: From Plants to a Cancer-Suppressing Agent

(2016) Angela Chapa-Oliver et al.   MOLECULES

Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells

(2016) Shanshan Jiang et al.   PHYTOMEDICINE

Erianin induces G2/M-phase arrest, apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo

(2016) H Wang et al.   Cell Death & Disease

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

MAPK/JNK signaling: A potential autophagy regulation pathway

(2015) Yuan-Yuan Zhou et al.   BIOSCIENCE REPORTS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

Biological Activities of Red Pepper (Capsicum annuum) and Its Pungent Principle Capsaicin: A Review

(2015) Krishnapura Srinivasan   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Isolation, identification and antioxidant activity of bound phenolic compounds present in rice bran

(2015) Wei Wang et al.   FOOD CHEMISTRY

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

(2015) Jie Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Cellular and metabolic functions for autophagy in cancer cells

(2015) Candia M. Kenific et al.   TRENDS IN CELL BIOLOGY

Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study

(2015) H-Y Li et al.   Cell Death & Disease

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

The pepper’s natural ingredient capsaicin induces autophagy blockage in prostate cancer cells

(2015) Ágata Ramos-Torres et al.   Oncotarget

Piperlonguminine is neuroprotective in experimental rat stroke

(2014) Tiansong Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isoorientin Induces Apoptosis and Autophagy Simultaneously by Reactive Oxygen Species (ROS)-Related p53, PI3K/Akt, JNK, and p38 Signaling Pathways in HepG2 Cancer Cells

(2014) Li Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs

(2014) Christopher John Bowman et al.   NATURE CELL BIOLOGY

Carnosol Induces ROS-Mediated Beclin1-Independent Autophagy and Apoptosis in Triple Negative Breast Cancer

(2014) Yusra Al Dhaheri et al.   PLoS One

Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways

(2014) Li Zhang et al.   TOXICOLOGY LETTERS

Tumor Suppression and Promotion by Autophagy

(2014) Yenniffer Ávalos et al.   Biomed Research International

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review

(2013) Ou Sha et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Curcumin, an Active Constiuent of the Ancient Medicinal Herb Curcuma longa L.: Some Uses and the Establishment and Biological Basis of Medical Efficacy

(2013) Jeffrey Witkin et al.   CNS & Neurological Disorders-Drug Targets

Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells

(2013) Paramasivan Poornima et al.   FOOD CHEMISTRY

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

(2013) Yung-Lin Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Autophagosome formation—The role of ULK1 and Beclin1–PI3KC3 complexes in setting the stage

(2013) Martina Wirth et al.   SEMINARS IN CANCER BIOLOGY

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo

(2012) Xiao-Min Yu et al.   CANCER

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

(2012) Daisuke Inoue et al.   CANCER SCIENCE

Overview of the therapeutic potential of piplartine (piperlongumine)

(2012) Daniel P. Bezerra et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway

(2012) Yajing Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

Phytochemicals to suppress Fusarium head blight in wheat–chickpea rotation

(2012) Andre F. Cruz et al.   PHYTOCHEMISTRY

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Involvement of ROS in Curcumin-induced Autophagic Cell Death

(2011) Youn Ju Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

(2011) Jun Bao et al.   RHEUMATOLOGY INTERNATIONAL

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

p53 and ARF: unexpected players in autophagy

(2010) Gregor M. Balaburski et al.   TRENDS IN CELL BIOLOGY

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+and AMP

(2009) Sarah Fogarty et al.   BIOCHEMICAL JOURNAL

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma

(2008) L. Longo et al.   MOLECULAR CANCER THERAPEUTICS

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY