Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis

Resveratrol protects Leydig cells from nicotine-induced oxidative damage through enhanced autophagy

(2018) Shengxian Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells

(2018) Fengyi Gao et al.   JOURNAL OF CELL BIOLOGY

Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia

(2018) Alexander Slowik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The balance between apoptosis and autophagy regulates testis regression and recrudescence in the seasonal-breeding South American plains vizcacha, Lagostomus maximus

(2018) Candela R. González et al.   PLoS One

ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells

(2018) Aijie Han et al.   TOXICOLOGY LETTERS

Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy

(2018) Sonia Sifuentes-Franco et al.   International Journal of Endocrinology

The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway

(2018) Hongfei Wu et al.   Frontiers in Pharmacology

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis

(2018) Christopher Geven et al.   Frontiers in Immunology

Autophagy-dependent cell death – where, how and why a cell eats itself to death

(2018) Shani Bialik et al.   JOURNAL OF CELL SCIENCE

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

(2018) Zhen Zhang et al.   Cell Death & Disease

Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

(2018) Wei-Ting Wong et al.   Frontiers in Immunology

The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy, and cell death

(2018) Qiongyuan Hu et al.   Acta Physiologica

Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells

(2017) Xian Xian et al.   ENDOCRINOLOGY

Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein

(2017) Shintaro Oka et al.   ENDOCRINOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways

(2017) Wei Hu et al.   Scientific Reports

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

(2016) Caixia Guo et al.   International Journal of Nanomedicine

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS

(2016) Jie Yang et al.   Cell Death & Disease

Influence of Testosterone on Inflammatory Response in Testicular Cells and Expression of Transcription Factor Foxp3 in T Cells

(2015) Monika Fijak et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1–AMPK–mTOR pathway

(2015) Guo-hua Li et al.   ATHEROSCLEROSIS

Effects of treatment with Astragalus Membranaceus on function of rat leydig cells

(2015) Xiaolong Jiang et al.   BMC Complementary and Alternative Medicine

Adrenomedullin attenuates interleukin-1β-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway

(2015) Wei Hu et al.   EXPERIMENTAL CELL RESEARCH

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

(2015) Xiaodi Fan et al.   Journal of Translational Medicine

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells

(2011) Wei-Ren Li et al.   ASIAN JOURNAL OF ANDROLOGY

Bacterial LPS Mediated Acute Inflammation-induced Spermatogenic Failure in Rats: Role of Stress Response Proteins and Mitochondrial Dysfunction

(2010) Mallikarjuna Reddy Metukuri et al.   INFLAMMATION

Adrenomedullin in the Rat Testis. I: Its Production, Actions on Testosterone Secretion, Regulation by Human Chorionic Gonadotropin, and Its Interaction with Endothelin 1 in the Leydig Cell1

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