Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Modulation of sestrin confers protection to Cr(VI) induced neuronal cell death in Drosophila melanogaster

(2018) Pallavi Singh et al.   CHEMOSPHERE

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis

(2018) Nina Zeng et al.   EXPERIMENTAL GERONTOLOGY

Reactive oxygen species and colorectal cancer

(2018) Sisi Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

(2018) Marco Cordani et al.   BRITISH JOURNAL OF CANCER

Fundamental mechanisms deliver the Nobel Prize to Ohsumi

(2017) Sharon A. Tooze et al.   TRAFFIC

Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer

(2017) Jin-Lai Wei et al.   Oncotarget

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling

(2017) Xuejin Wang et al.   Oncotarget

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

(2017) Jun-Kyu Byun et al.   Cell Reports

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

(2016) Min-Ji Kim et al.   Autophagy

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

(2016) Scot R. Kimball et al.   CELLULAR SIGNALLING

Relative Alterations in Blood-Based Levels of Sestrin in Alzheimer’s Disease and Mild Cognitive Impairment Patients

(2016) Nitish Rai et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

(2016) Xudan Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Environmental Presence of Hexavalent but Not Trivalent Chromium Causes Neurotoxicity in Exposed Drosophila melanogaster

(2016) Pallavi Singh et al.   MOLECULAR NEUROBIOLOGY

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats

(2016) Xudan Shi et al.   NEUROBIOLOGY OF DISEASE

Biochemical Basis of Sestrin Physiological Activities

(2016) Allison Ho et al.   TRENDS IN BIOCHEMICAL SCIENCES

Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner

(2016) Victoria I. Bunik et al.   Oncotarget

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity

(2015) Wenbo Yi et al.   METABOLIC BRAIN DISEASE

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

(2015) Yi-Sheng Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

(2015) Hanseong Kim et al.   Nature Communications

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

(2015) Anna Baulies et al.   Scientific Reports

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade

(2015) Juan F. Linares et al.   Cell Reports

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

(2015) Jeong Sig Kim et al.   Scientific Reports

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy

(2014) Sungwoo Park et al.   Autophagy

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

(2014) Min Peng et al.   CELL

Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II

(2014) Lao Yi et al.   CELL BIOLOGY AND TOXICOLOGY

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1

(2014) Seung-Hyun Ro et al.   FEBS Journal

Mitophagy mechanisms and role in human diseases

(2014) Matthew Redmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Adamts1 Mediates Ethanol-Induced Alterations in Collagen and Elastin via a FoxO1-Sestrin3-AMPK Signaling Cascade in Myocytes

(2014) Ly Q Hong-Brown et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer

(2014) JIN-LAI WEI et al.   ONCOLOGY REPORTS

Hepatoprotective role of Sestrin2 against chronic ER stress

(2014) Hwan-Woo Park et al.   Nature Communications

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

(2013) Ya-Luen Yang et al.   EXPERIMENTAL GERONTOLOGY

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture

(2013) Yueh-Sheng Chen et al.   EXPERIMENTAL NEUROLOGY

Reactive Oxygen Species in the Immune System

(2013) Yuhui Yang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Upregulation of Sestrin-2 Expression via P53 Protects Against 1-Methyl-4-Phenylpyridinium (MPP+) Neurotoxicity

(2013) Zhou Daixing et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

(2013) Assaad A. Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation

(2013) Ansgar Brüning et al.   Molecular Oncology

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sevoflurane Induces Endoplasmic Reticulum Stress Mediated Apoptosis in Hippocampal Neurons of Aging Rats

(2013) Gang Chen et al.   PLoS One

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers

(2012) Virawudh Soontornniyomkij et al.   AIDS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells

(2012) Xiao-Yue Zhang et al.   CELLULAR SIGNALLING

Nrf2-ARE pathway regulates induction of Sestrin-2 expression

(2012) Bo Yeon Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

(2012) J. Hagenbuchner et al.   JOURNAL OF CELL SCIENCE

Ameliorating effect of selenium on chromium (VI)-induced oxidative damage in the brain of adult rats

(2012) Nejla Soudani et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

Regulation and Function of Uncoordinated-51 Like Kinase Proteins

(2011) Edmond Y. Chan   ANTIOXIDANTS & REDOX SIGNALING

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

The Role of Oxidative Stress in the Aging Process

(2011) Barbara F. Oliveira et al.   TheScientificWorldJOURNAL

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model

(2010) Satyanarayana Paturi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Oxidative stress in early diabetic nephropathy: fueling the fire

(2010) Dhruv K. Singh et al.   Nature Reviews Endocrinology

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase

(2010) Xin Chen et al.   NUCLEIC ACIDS RESEARCH

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

(2008) Hyun Ae Woo et al.   ANTIOXIDANTS & REDOX SIGNALING

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Phosphoproteome Analysis ofDrosophila melanogasterEmbryos

(2008) Bo Zhai et al.   JOURNAL OF PROTEOME RESEARCH

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE