Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

Transcriptional regulation of autophagy‐lysosomal pathway in cancer

(2020) Xinzhong Chang et al.   Thoracic Cancer

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation

(2020) Fuqing Hu et al.   Cell Death & Disease

Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy

(2020) Ting Liu et al.   Frontiers in Pharmacology

p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4)

(2020) Mi-Jeong Kim et al.   Cells

Comprehensive analysis of autophagy‐related prognostic genes in breast cancer

(2020) Jianguo Lai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of ATG4a promotes autophagy and proliferation, and inhibits apoptosis in lens epithelial cells via the AMPK and Akt pathways

(2020) Chufan Yan et al.   Molecular Medicine Reports

The CCL5/CCR5 Axis in Cancer Progression

(2020) Donatella Aldinucci et al.   Cancers

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Superior Effect of the Combination of Carbon-Ion Beam Irradiation and 5-Fluorouracil on Colorectal Cancer Stem Cells in vitro and in vivo

(2020) Woong Sub Koom et al.   OncoTargets and Therapy

mTOR and Beclin1: Two key autophagy-related molecules and their roles in myocardial ischemia/reperfusion injury

(2019) Binhao Shi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells

(2019) Robert C. Fisher et al.   NEOPLASIA

Low-dose IFN-γ induces tumor cell stemness in the tumor microenvironment of non-small cell lung cancer

(2019) Mengjia Song et al.   CANCER RESEARCH

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia

(2019) Clément Larrue et al.   Oncogenesis

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

(2019) Rekha Khandia et al.   Cells

The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy

(2019) Marie Chollat-Namy et al.   Cell Death & Disease

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

(2019) Komal Qureshi-Baig et al.   Autophagy

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

(2019) Shohei Yoshimoto et al.   Cancer Medicine

Stabilization of Hypoxia-Inducible Factors and BNIP3 Promoter Methylation Contribute to Acquired Sorafenib Resistance in Human Hepatocarcinoma Cells

(2019) Carolina Méndez-Blanco et al.   Cancers

Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts

(2019) Nattanan Losuwannarak et al.   Cancers

Hypoxia-inducible factor-1α-dependent autophagy plays a role in glycolysis switch in mouse granulosa cells†

(2018) Jilong Zhou et al.   BIOLOGY OF REPRODUCTION

STAT3, stem cells, cancer stem cells and p63

(2018) Michaela Galoczova et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The role of IL-1B in breast cancer bone metastasis

(2018) Claudia Tulotta et al.   ENDOCRINE-RELATED CANCER

Cancer stem cells and hypoxia-inducible factors (Review)

(2018) Wei-Wei Tong et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Knockdown of Beclin-1 impairs epithelial-mesenchymal transition of colon cancer cells

(2018) Hong Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

(2018) Tianxiao Gong et al.   Journal of Translational Medicine

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

(2018) Sijia He et al.   Cell Death & Disease

High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance

(2018) In-geun Ryoo et al.   Redox Biology

Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo

(2018) Yuanyuan Fu et al.   Autophagy

Hypoxia induces ZEB2 in podocytes: Implications in the pathogenesis of proteinuria

(2018) Krishnamurthy Nakuluri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells

(2018) Themis Alissafi et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning

(2018) Na Lu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

(2018) Stéphane Terry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma

(2018) Yanxiang Shao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1

(2018) Minhyeong Seong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway

(2018) Weiyi Huang et al.   NEUROREPORT

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

(2018) Zhi-Fa Wen et al.   Journal for ImmunoTherapy of Cancer

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

(2017) Norma Bloy et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter

(2017) Meriem Hasmim et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

(2017) Srirupa Roy et al.   MOLECULAR CELL

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

(2017) Takouhie Mgrditchian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

(2017) Vito W. Rebecca et al.   Cancer Discovery

Transcriptional response to hypoxic stress in melanoma and prognostic potential of GBE1 and BNIP3

(2017) Stéphanie Buart et al.   Oncotarget

Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation

(2017) Jianming He et al.   Journal of Cancer

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors

(2016) Gregg L. Semenza   MOLECULAR ASPECTS OF MEDICINE

Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms

(2016) Y. Qian et al.   MOLECULAR CANCER RESEARCH

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

(2016) L-Z Xu et al.   ONCOGENE

Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism

(2016) LAN GUI et al.   Experimental and Therapeutic Medicine

The multifaceted role of autophagy in tumor evasion from immune surveillance

(2016) Bassam Janji et al.   Oncotarget

ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells

(2016) Shi-Wei Yang et al.   Oncotarget

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

(2016) Jae-Kyo Jeong et al.   Scientific Reports

Tumor suppressor functions of BNIP3 and mitophagy

(2015) Aparajita H Chourasia et al.   Autophagy

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

p53-mediated autophagic regulation: A prospective strategy for cancer therapy

(2015) Juanjuan Tang et al.   CANCER LETTERS

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

(2015) Bao-quan Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

(2015) Andrés Tittarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Mediates HBx-Induced Nuclear Factor-κB Activation and Release of IL-6, IL-8, and CXCL2 in Hepatocytes

(2015) Millore X.M. Luo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells

(2015) Hui-Mei Wu et al.   Scientific Reports

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

(2015) Wenjing Zhang et al.   PLoS One

Identification of secreted proteins that reflect autophagy dynamics within tumor cells

(2014) Adam A. Kraya et al.   Autophagy

Autophagy in non-small cell lung carcinogenesis

(2014) Shuan Rao et al.   Autophagy

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations

(2014) M Moschetta et al.   BRITISH JOURNAL OF PHARMACOLOGY

ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy

(2014) Y. Messai et al.   CANCER RESEARCH

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α

(2014) XIAOCHEN LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression

(2014) I Akalay et al.   ONCOGENE

Autophagy and hippocampal neuronal injury

(2014) Lulu Li et al.   Sleep and Breathing

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

(2013) Abhishek D. Garg et al.   Autophagy

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Hypoxic Activation of the PERK/eIF2  Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

(2013) H. Mujcic et al.   CLINICAL CANCER RESEARCH

Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

(2013) Faton Agani et al.   CURRENT CANCER DRUG TARGETS

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance

(2013) Shu-Chen Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

(2013) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Targeting autophagy as a potential therapeutic approach for melanoma therapy

(2013) He Liu et al.   SEMINARS IN CANCER BIOLOGY

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

(2013) W Hou et al.   Cell Death & Disease

mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions

(2013) Shyuichiro Matsubara et al.   Scientific Reports

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

The end of autophagic cell death?

(2012) Shensi Shen et al.   Autophagy

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

(2012) Katelin N. Townsend et al.   IMMUNOLOGICAL REVIEWS

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

(2012) S Galavotti et al.   ONCOGENE

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Autophagy Creates a CTL Epitope That Mimics Tumor-Associated Antigens

(2012) Ayako Demachi-Okamura et al.   PLoS One

Hypoxia-Inducible Factor 1 Alpha Contributes to Cardiac Healing in Mesenchymal Stem Cells-Mediated Cardiac Repair

(2012) Inmaculada Cerrada et al.   STEM CELLS AND DEVELOPMENT

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

(2011) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

Autophagic cell death: Loch Ness monster or endangered species?

(2011) Han-Ming Shen et al.   Autophagy

Beclin1/PI3K-Mediated Autophagy Prevents Hypoxia-Induced Apoptosis in EAhy926 Cell Line

(2011) Ruiguang Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Autophagy positively regulates the CD44+CD24-/lowbreast cancer stem-like phenotype

(2011) Sílvia Cufí et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

A downside to apoptosis in cancer therapy?

(2011) Philip P Connell et al.   NATURE MEDICINE

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies

(2010) Meghan B. Azad et al.   Annals of the New York Academy of Sciences

Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

(2010) Insil Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during lateDrosophila melanogasteroogenesis

(2010) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

(2009) Esther A Koop et al.   BMC CANCER

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death

(2009) Julia Grohm et al.   BRAIN BEHAVIOR AND IMMUNITY

mTOR Signal and Hypoxia-Inducible Factor-1  Regulate CD133 Expression in Cancer Cells

(2009) K. Matsumoto et al.   CANCER RESEARCH

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

(2009) Johanna Chiche et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Autophagy regulates selective HMGB1 release in tumor cells that are destined to die

(2008) J Thorburn et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antagonism of E2F-1 regulated Bnip3 transcription by NF- B is essential for basal cell survival

(2008) J. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cell Cycle Factor E2F-1 Activates Bnip3 and the Intrinsic Death Pathway in Ventricular Myocytes

(2007) Natalia Yurkova et al.   CIRCULATION RESEARCH