Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ

(2019) Alicia Bort et al.   PLoS One

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression

(2019) Yong Guo et al.   BIOSCIENCE REPORTS

ZBTB7A promotes migration, invasion and metastasis of human breast cancer cells through NF-κB-induced epithelial–mesenchymal transition in vitro and in vivo

(2019) Anyun Mao et al.   JOURNAL OF BIOCHEMISTRY

Application of capsaicin as a potential new therapeutic drug in human cancers

(2019) Shengping Zhang et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Breast cancer statistics, 2019

(2019) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β‐catenin pathway

(2019) Mingming Zhu et al.   PHYTOTHERAPY RESEARCH

Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha

(2019) Xiao Xiao et al.   LIFE SCIENCES

XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-κB/p53/Ki67 signaling pathway

(2018) Bo Xu et al.   BIOSCIENCE REPORTS

Ki67 Changes Identify Worse Outcomes in Residual Breast Cancer Tumors After Neoadjuvant Chemotherapy

(2018) Paula Cabrera‐Galeana et al.   ONCOLOGIST

Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors

(2018) José Miguel Ramos Pittol et al.   PLOS BIOLOGY

Relationship between the Ki67 index and its area based approximation in breast cancer

(2018) Muhammad Khalid Khan Niazi et al.   BMC CANCER

Dietary Natural Products for Prevention and Treatment of Breast Cancer

(2017) Ya Li et al.   Nutrients

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

(2016) Victor Fattori et al.   MOLECULES

Capsaicin: From Plants to a Cancer-Suppressing Agent

(2016) Angela Chapa-Oliver et al.   MOLECULES

Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways

(2016) Kaiyu Qian et al.   MOLECULES

FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling

(2015) Victor C.Y. Mak et al.   AMERICAN JOURNAL OF PATHOLOGY

Synergistic Anticancer Activity of Capsaicin and 3,3′-Diindolylmethane in Human Colorectal Cancer

(2015) Ruth Clark et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM

(2015) X.-S. Liu et al.   MOLECULAR CANCER RESEARCH

Resveratrol Represses Pokemon Expression in Human Glioma Cells

(2015) Yutao Yang et al.   MOLECULAR NEUROBIOLOGY

Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway

(2014) Yongwei Wang et al.   BIOCHEMICAL PHARMACOLOGY

Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway

(2014) Gong-Rak Lee et al.   CLINICAL & EXPERIMENTAL METASTASIS

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Mechanisms and clinical uses of capsaicin

(2013) Surinder Kumar Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice

(2013) P. Anandakumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Knockdown of Pokemon Protein Expression Inhibits Hepatocellular Carcinoma Cell Proliferation by Suppression of AKT Activity

(2013) Xiaosan Zhu et al.   ONCOLOGY RESEARCH

Silencing of Pokemon Enhances Caspase-Dependent Apoptosis via Fas- and Mitochondria-Mediated Pathways in Hepatocellular Carcinoma Cells

(2013) Yu-Qin Zhang et al.   PLoS One

Endoplasmic reticulum chaperone glucose regulated protein 170–Pokemon complexes elicit a robust antitumor immune response in vivo

(2012) Bangqing Yuan et al.   IMMUNOBIOLOGY

Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model

(2012) P. Anandakumar et al.   INFLAMMATION RESEARCH

Homeostatic regulatory role of Pokemon in NF-κB signaling: stimulating both p65 and IκBα expression in human hepatocellular carcinoma cells

(2012) Nan-Nan Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Pokemon reduces Bcl—2 expression through NF—κ Bp65: a possible mechanism of hepatocellular carcinoma

(2011) Xinkai Zhao et al.   Asian Pacific Journal of Tropical Medicine

ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

(2010) Hongyan Qu et al.   CANCER INVESTIGATION

Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers

(2010) Anshu Aggarwal et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Proto-oncogene FBI-1 Represses Transcription ofp21CIP1by Inhibition of Transcription Activation by p53 and Sp1

(2009) Won-Il Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway

(2009) N H Thoennissen et al.   ONCOGENE

Capsaicin Mediates Cell Death in Bladder Cancer T24 Cells Through Reactive Oxygen Species Production and Mitochondrial Depolarization

(2009) Zhong-Hua Yang et al.   UROLOGY

Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor SuppressorRbGene via Binding Competition with Sp1 and Recruitment of Co-repressors

(2008) Bu-Nam Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY