- Home
- Publications
- Publication Search
- Publication Details
Title
mTOR Pathways in Cancer and Autophagy
Authors
Keywords
-
Journal
Cancers
Volume 10, Issue 1, Pages 18
Publisher
MDPI AG
Online
2018-01-15
DOI
10.3390/cancers10010018
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
- (2017) Ming-Yuan Su et al. MOLECULAR CELL
- Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
- (2017) Chen-Song Zhang et al. NATURE
- Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
- (2017) Jong Hyun Kim et al. Nature Communications
- Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
- (2017) Hayden Weng Siong Tan et al. Nature Communications
- TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages
- (2016) Nunzia Pastore et al. Autophagy
- Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton
- (2016) Andrei S Chagin CURRENT OPINION IN PHARMACOLOGY
- Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes
- (2016) Georgina P Starling et al. EMBO REPORTS
- Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
- (2016) Ming Yan et al. GENES & DEVELOPMENT
- AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
- (2016) Nathan P. Young et al. GENES & DEVELOPMENT
- Recent insights into the function of autophagy in cancer: Table 1.
- (2016) Ravi Amaravadi et al. GENES & DEVELOPMENT
- The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
- (2016) Shogo Wada et al. GENES & DEVELOPMENT
- ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models
- (2016) Mitchell S. Wold et al. Molecular Neurodegeneration
- AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
- (2016) Hi-Jai R. Shin et al. NATURE
- Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
- (2016) Vanessa S. Rodrik-Outmezguine et al. NATURE
- Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis
- (2016) Uddin Nazim et al. Oncotarget
- An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense
- (2016) Mehran Najibi et al. Cell Reports
- Therapeutic Targeting of Autophagy
- (2016) Christina G. Towers et al. EBioMedicine
- MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation
- (2015) Mohamad-Ali Fawal et al. DEVELOPMENTAL CELL
- Autophagy in malignant transformation and cancer progression
- (2015) L. Galluzzi et al. EMBO JOURNAL
- Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome
- (2015) Hisashi Hasumi et al. INTERNATIONAL JOURNAL OF UROLOGY
- Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
- (2015) Laura A. Stransky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression
- (2015) Mingsong Wu et al. Oncotarget
- Point mutations of the mTOR-RHEB pathway in renal cell carcinoma
- (2015) Arindam P. Ghosh et al. Oncotarget
- Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
- (2015) Marie-Pierre Péli-Gulli et al. Cell Reports
- Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
- (2015) Junghyun Lim et al. PLoS Genetics
- FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores
- (2015) Elite Possik et al. PLoS Genetics
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
- (2014) Chen-Song Zhang et al. Cell Metabolism
- Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
- (2014) Yukiko Hasumi et al. HUMAN MOLECULAR GENETICS
- Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes
- (2014) Orane Visvikis et al. IMMUNITY
- The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
- (2014) Ming Yan et al. JOURNAL OF CLINICAL INVESTIGATION
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- (2014) J. A. Martina et al. Science Signaling
- Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
- (2014) Y Feng et al. Cell Death & Disease
- Rag GTPases are cardioprotective by regulating lysosomal function
- (2014) Young Chul Kim et al. Nature Communications
- Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival
- (2014) Elite Possik et al. PLoS Genetics
- Prolonged autophagy by MTOR inhibitor leads radioresistant cancer cells into senescence
- (2013) Hae Yun Nam et al. Autophagy
- Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
- (2013) Hai-Xin Yuan et al. Autophagy
- AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
- (2013) Ya-Lin Zhang et al. Cell Metabolism
- Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
- (2013) Constance S. Petit et al. JOURNAL OF CELL BIOLOGY
- Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
- (2013) Jose A. Martina et al. JOURNAL OF CELL BIOLOGY
- Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide
- (2013) Andrey A. Parkhitko et al. MOLECULAR CANCER RESEARCH
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
- (2013) Francesca Nazio et al. NATURE CELL BIOLOGY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Autophagy in Human Health and Disease
- (2013) Augustine M.K. Choi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Glutamine stimulates mTORC1 independent of the cell content of essential amino acids
- (2012) Martina Chiu et al. AMINO ACIDS
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- (2012) Jung Min Han et al. CELL
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- The mTOR Signalling Pathway in Human Cancer
- (2012) Helena Pópulo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex
- (2012) Grégory Bonfils et al. MOLECULAR CELL
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Emerging Treatments in the Management of Tuberous Sclerosis Complex
- (2012) Michael H. Kohrman PEDIATRIC NEUROLOGY
- Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes
- (2012) Margrét H. Ögmundsdóttir et al. PLoS One
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
- (2011) Chang Hwa Jung et al. Autophagy
- ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
- (2011) Elaine A. Dunlop et al. Autophagy
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
- (2011) Antje S. Löffler et al. Autophagy
- The serine/threonine kinase ULK1 is a target of multiple phosphorylation events
- (2011) Markus Bach et al. BIOCHEMICAL JOURNAL
- Autophagy as a therapeutic target in cancer
- (2011) Ning Chen et al. CANCER BIOLOGY & THERAPY
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
- Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
- (2011) R. K. Amaravadi et al. CLINICAL CANCER RESEARCH
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
- (2011) S Shen et al. ONCOGENE
- Targeting autophagy during cancer therapy to improve clinical outcomes
- (2011) Jean M. Mulcahy Levy et al. PHARMACOLOGY & THERAPEUTICS
- Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
- (2011) L. Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
- (2011) Hakan Cam et al. Targeted Oncology
- Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
- (2011) T Tomic et al. Cell Death & Disease
- Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer
- (2010) Kevin Dalby et al. Autophagy
- Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,
- (2010) Silvia Vega-Rubin-de-Celis et al. BIOCHEMISTRY
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
- (2010) Itay Koren et al. CURRENT BIOLOGY
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- (2010) Won Jun Oh et al. EMBO JOURNAL
- The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
- (2010) Sabrina Di Bartolomeo et al. JOURNAL OF CELL BIOLOGY
- Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
- (2010) Kohichi Matsunaga et al. JOURNAL OF CELL BIOLOGY
- The DNA Damage Response: Making It Safe to Play with Knives
- (2010) Alberto Ciccia et al. MOLECULAR CELL
- Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
- (2010) S Heublein et al. ONCOGENE
- The Association of AMPK with ULK1 Regulates Autophagy
- (2010) Jong Woo Lee et al. PLoS One
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1
- (2009) Joseph Avruch et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Anti- and pro-tumor functions of autophagy
- (2009) Eugenia Morselli et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Double-Edged Sword of Autophagy Modulation in Cancer
- (2009) E. White et al. CLINICAL CANCER RESEARCH
- PI3K and mTOR inhibitors—a new generation of targeted anticancer agents
- (2009) Saskia Brachmann et al. CURRENT OPINION IN CELL BIOLOGY
- Autophagy genes as tumor suppressors
- (2009) Chengyu Liang et al. CURRENT OPINION IN CELL BIOLOGY
- Hypoxia-induced autophagy: cell death or cell survival?
- (2009) Nathalie M Mazure et al. CURRENT OPINION IN CELL BIOLOGY
- Autophagy-A double-edged sword in oncology
- (2009) Anja Apel et al. INTERNATIONAL JOURNAL OF CANCER
- Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein
- (2009) Tatsuhiro Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- Renal tumour suppressor function of the Birt-Hogg-Dube syndrome gene product folliculin
- (2009) V. Hudon et al. JOURNAL OF MEDICAL GENETICS
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Autophagy in tumour suppression and promotion
- (2009) Andreas Brech et al. Molecular Oncology
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Amino acid regulation of TOR complex 1
- (2008) Joseph Avruch et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
- (2008) Jingxiang Huang et al. BIOCHEMICAL JOURNAL
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
- (2008) Zhen Lu et al. JOURNAL OF CLINICAL INVESTIGATION
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now