Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats

Empagliflozin prevents from early cardiac injury post myocardial infarction in non-diabetic mice

(2021) Yihai Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPARγ/ NF-κB signaling pathway in C6 glioma cells

(2021) Ceyhan Hacioglu et al.   MEDICAL ONCOLOGY

Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats

(2021) Adel T. Osman et al.   LIFE SCIENCES

Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats

(2020) Ramadan M. Abdelaziz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling

(2020) Omnia E. Hussein et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Empagliflozin ameliorates endothelial dysfunction and suppresses atherogenesis in diabetic apolipoprotein E-deficient mice

(2020) Byambasuren Ganbaatar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO/TNF-α and caspase 3 activities

(2020) Roland Akhigbe et al.   PLoS One

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

(2020) Mehdi Sharifi-Rad et al.   Frontiers in Physiology

The effects of N-acetylcysteine on inflammatory and oxidative stress biomarkers: A systematic review and meta-analysis of controlled clinical trials

(2020) Amir Hossein Faghfouri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways

(2020) Hye-Young Seo et al.   PLoS One

Cilostazol mitigates mesenteric ischemia/reperfusion-induced lung lesion: Contribution of PPAR-γ, NF-κB, and STAT3 crosstalk

(2020) Abdallah M. Gendy et al.   LIFE SCIENCES

Antihyperglycemic and Blood Pressure Effects of Empagliflozin in African Americans with Type 2 Diabetes and Hypertension

(2019) Keith C. Ferdinand et al.   CIRCULATION

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

(2019) Chenguang Li et al.   Cardiovascular Diabetology

The sodium–glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats

(2019) Hsiang-Chun Lee et al.   Cardiovascular Diabetology

Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling

(2019) Sanaa M. Abd El-Twab et al.   INFLAMMATION RESEARCH

Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats

(2019) Mojtaba Kalantar et al.   Pharmacological Reports

Empagliflozin Improves Kidney Outcomes in Patients With or Without Heart Failure

(2019) Javed Butler et al.   Circulation-Heart Failure

Ethanol exposure in prenatal and early postnatal induced cardiac injury in rats: involvement of oxidative stress, Hsp70, ERK 1/2, JNK, and apoptosis in a 3-month follow-up study

(2019) Alireza Shirpoor et al.   CELL STRESS & CHAPERONES

Heat Shock Proteins: Dynamic Biomolecules to Counter Plant Biotic and Abiotic Stresses

(2019) ul Haq et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742

(2019) Chunxia Guo et al.   MOLECULES

Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review

(2019) Monika Stompor et al.   MOLECULES

Biochemical investigation of gender-specific association between insulin resistance and inflammatory biomarkers in types 2 diabetic patients

(2018) Muhammad Sajid Hamid Akash et al.   BIOMEDICINE & PHARMACOTHERAPY

Potential mechanisms responsible for cardioprotective effects of sodium–glucose co-transporter 2 inhibitors

(2018) Sarayut Lahnwong et al.   Cardiovascular Diabetology

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells

(2018) Min Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

EMPAGLIFLOZIN AND CANAGLIFLOZIN ATTENUATE INFLAMMATORY CYTOKINES INTERFERON-λ, TUMOR NECROSIS FACTOR-α, INTERLEUKIN-6: POSSIBLE MECHANISM OF DECREASING CARDIOVASCULAR RISK IN DIABETES MELLITUS

(2018) Stanley Andrew Tan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Camel milk attenuates methotrexate-induced kidney injury via activation of PI3K/Akt/eNOS signaling and intervention with oxidative aberrations

(2018) Hany H. Arab et al.   Food & Function

Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

(2018) Kyung Ae Lee et al.   Diabetes & Metabolism Journal

Protective antioxidant effects of N -acetylcysteine against impairment of spermatogenesis caused by paranonylphenol

(2018) Mahdi Malmir et al.   ANDROLOGIA

Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

(2018) Yuichi Saito et al.   Redox Biology

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

(2018) Mikolaj Ogrodnik et al.   AGING CELL

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

(2018) Emad H.M. Hassanein et al.   BIOMEDICINE & PHARMACOTHERAPY

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat

(2018) Chih-Chao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY