Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance

(2017) Yingzhi Chen et al.   MOLECULAR PHARMACEUTICS

Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface

(2017) Chunman Li et al.   Oncotarget

A novel trichosanthin fusion protein with increased cytotoxicity to tumor cells

(2016) Bing Lin et al.   BIOTECHNOLOGY LETTERS

Enhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activity

(2016) Ye-Zhou Lu et al.   FITOTERAPIA

Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway

(2016) Bin Wei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in CaSki cervical cancer cells

(2015) Lei Cui et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of Radix Trichosanthis and Trichosanthin on Hepatitis B Virus in HepG2.2.15 Cells

(2015) Doudou Wen et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Trichosanthin reduces the viability of SU-DHL-2 cells via the activation of the extrinsic and intrinsic apoptotic pathways

(2015) YINGJIE ZHU et al.   Molecular Medicine Reports

Trichosanthin suppresses the proliferation of glioma cells by inhibiting LGR5 expression and the Wnt/β-catenin signaling pathway

(2015) JUNJIE MIAO et al.   ONCOLOGY REPORTS

PTD-Modified ATTEMPTS for Enhanced Toxin-based Cancer Therapy: An In Vivo Proof-of-Concept Study

(2015) Meong Cheol Shin et al.   PHARMACEUTICAL RESEARCH

Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances

(2015) Nikhil Tyagi et al.   TUMOR BIOLOGY

Structures of Eukaryotic Ribosomal Stalk Proteins and Its Complex with Trichosanthin, and Their Implications in Recruiting Ribosome-Inactivating Proteins to the Ribosomes

(2015) Andrew Choi et al.   Toxins

A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8+CD28− Tregs

(2014) Neng Yang et al.   CLINICAL IMMUNOLOGY

Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

(2014) Roger Gilabert-Oriol et al.   CURRENT PHARMACEUTICAL DESIGN

Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c-Jun N-terminal protein kinase/mitogen-activated protein kinase activation

(2014) DUO ZHANG et al.   Molecular Medicine Reports

Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1α

(2014) Kosuke Ito et al.   NUCLEIC ACIDS RESEARCH

Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review

(2013) Ou Sha et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Involvement of Nuclear Factor κB (NF-κB) in the Downregulation of Cyclo-Oxygenase-2 (COX-2) by Genistein in Gastric Cancer Cells

(2013) Y-S Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Solution structure of human P1*P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome

(2013) K.-M. Lee et al.   NUCLEIC ACIDS RESEARCH

Induction of Apoptosis by Ribosome Inactivating Proteins

(2012) Mrinal Kumar Das et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells

(2012) Eeda Venkateswararao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The anti-herpetic activity of trichosanthin via the nuclear factor-κB and p53 pathways

(2012) Dongxu He et al.   LIFE SCIENCES

Trichosanthin inhibits DNA methyltransferase and restores methylation-silenced gene expression in human cervical cancer cells

(2012) YILING HUANG et al.   Molecular Medicine Reports

Charged and Hydrophobic Surfaces on the A Chain of Shiga-Like Toxin 1 Recognize the C-Terminal Domain of Ribosomal Stalk Proteins

(2012) Andrew J. McCluskey et al.   PLoS One

Trichosanthin Inhibits Breast Cancer Cell Proliferation in Both Cell Lines and Nude Mice by Promotion of Apoptosis

(2012) Evandro Fei Fang et al.   PLoS One

Archaeal ribosomal stalk protein interacts with translation factors in a nucleotide-independent manner via its conserved C terminus

(2012) N. Nomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM

(2011) Yuchan Cai et al.   Cellular & Molecular Immunology

Recent Progress in Medicinal Investigations on Trichosanthin and other Ribosome Inactivating Proteins from the Plant Genus Trichosanthes

(2011) E. F. Fang et al.   CURRENT MEDICINAL CHEMISTRY

IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat

(2011) Pedro Alvarez et al.   EXPERIMENTAL NEUROLOGY

Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex

(2011) Ka-Ming Lee et al.   NUCLEIC ACIDS RESEARCH

Possible Mechanisms of Trichosanthin-Induced Apoptosis of Tumor Cells

(2010) Meng Li et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Trichosanthin affects HSV-1 replication in Hep-2 cells

(2010) Dong-Xu He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increase of cytosolic calcium induced by trichosanthin suppresses cAMP/PKC levels through the inhibition of adenylyl cyclase activity in HeLa cells

(2010) Qingsong Jiang et al.   MOLECULAR BIOLOGY REPORTS

Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk

(2010) Ka-Ming Lee et al.   NUCLEIC ACIDS RESEARCH

The mechanisms of action of Tianhua™on antitumor activity in lung cancer cells

(2010) Chien-Te Li et al.   PHARMACEUTICAL BIOLOGY

A Role for Trichosanthin in the Expansion of CD4+CD25+Regulatory T Cells

(2010) B.-L. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack

(2010) Maddalena de Virgilio et al.   Toxins

The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1

(2009) W. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

A novel sorting strategy of trichosanthin for hijacking human immunodeficiency virus type 1

(2009) Wen-Long Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell lines

(2009) YiZu Jiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis for Translation Factor Recruitment to the Eukaryotic/Archaeal Ribosomes

(2009) Takao Naganuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of an Active Mutant of Maize Ribosome-Inactivating Protein (MOD) and Its Interaction with the Ribosomal Stalk Protein P2

(2009) Yinhua Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Trichosanthin inhibits integration of human immunodeficiency virus type 1 through depurinating the long-terminal repeats

(2009) Wen-Long Zhao et al.   MOLECULAR BIOLOGY REPORTS

CREB, a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis

(2009) Ping Wang et al.   MOLECULAR BIOLOGY REPORTS

Trichosanthin suppresses HeLa cell proliferation through inhibition of the PKC/MAPK signaling pathway

(2008) Ping Wang et al.   CELL BIOLOGY AND TOXICOLOGY

The Catalytic Subunit of Shiga-like Toxin 1 Interacts with Ribosomal Stalk Proteins and is Inhibited by Their Conserved C-Terminal Domain

(2008) Andrew J. McCluskey et al.   JOURNAL OF MOLECULAR BIOLOGY

Induced apoptotic action of recombinant trichosanthin in human stomach adenocarcinoma MCG803 cells

(2008) Jun Xu et al.   MOLECULAR BIOLOGY REPORTS

The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome

(2008) Priscilla Hiu-Mei Too et al.   NUCLEIC ACIDS RESEARCH

Trichosanthin, an Extract of Trichosanthes kirilowii, Effectively Prevents Acute Rejection of Major Histocompatibility Complex–Mismatched Mouse Skin Allograft

(2008) Q. Gong et al.   TRANSPLANTATION PROCEEDINGS