Oxidative Stress: Harms and Benefits for Human Health

γ-Tocopherol supplementation of allergic female mice augments development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates

(2016) Hiam Abdala-Valencia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

Interaction of vitamin E isoforms on asthma and allergic airway disease

(2016) Joan Cook-Mills et al.   THORAX

Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors

(2015) Xujuan Yang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cadmium delays puberty onset and testis growth in adolescents

(2015) Monica Interdonato et al.   CLINICAL ENDOCRINOLOGY

Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

(2015) Shreyasi Palit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genistein modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats

(2015) Ajaz A. Ganai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells

(2015) Qiang Zhang et al.   Food & Function

Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway

(2015) Mahmoud Alhosin et al.   Scientific Reports

α-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates

(2014) Hiam Abdala-Valencia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr−/− mice, but not when fed Western style diet

(2014) Mohsen Meydani et al.   ATHEROSCLEROSIS

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway

(2014) J. Wang et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Therapeutic perspectives of epigenetically active nutrients

(2014) M Remely et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antioxidants and human diseases

(2014) Peramaiyan Rajendran et al.   CLINICA CHIMICA ACTA

Tracing the fates of site-specifically introduced DNA adducts in the human genome

(2014) Manabu Yasui et al.   DNA REPAIR

Vitamin E and D regulation of allergic asthma immunopathogenesis

(2014) Joan M. Cook-Mills et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin Induced Human Gastric Cancer BGC-823 Cells Apoptosis by ROS-Mediated ASK1-MKK4-JNK Stress Signaling Pathway

(2014) Tao Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs

(2014) Maren C. Podszun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin E Conditionally Inhibits Atherosclerosis in ApoE Knockout Mice by Anti-oxidation and Regulation of Vasculature Gene Expressions

(2014) Futian Tang et al.   LIPIDS

The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study

(2014) Michelle E Marchese et al.   RESPIRATORY RESEARCH

Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation

(2014) Lijuan Sun et al.   Food & Function

Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy)

(2014) Gabriele Pizzino et al.   Redox Biology

Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis

(2014) Erdi Sozen et al.   Redox Biology

Two Faces of Vitamin E in the Lung

(2013) Joan M. Cook-Mills et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models

(2013) Shashank Kumar et al.   BMC Complementary and Alternative Medicine

Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells

(2013) Cheng Luo et al.   CURRENT CANCER DRUG TARGETS

Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis

(2013) Naoshi Nishida et al.   DIGESTIVE DISEASES

Differential cellular localization of antioxidant enzymes in the trigeminal ganglion

(2013) H. Sato et al.   NEUROSCIENCE

Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase

(2013) Jong Hun Kim et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Antioxidant gene therapy against neuronal cell death

(2013) Juliana Navarro-Yepes et al.   PHARMACOLOGY & THERAPEUTICS

Free radicals, antioxidant defense systems, and schizophrenia

(2013) Jing Qin Wu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Scientific Validation of the Medicinal Efficacy ofTinospora cordifolia

(2013) Amita Mishra et al.   TheScientificWorldJOURNAL

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Phenolic Content, Reducing Power and Membrane Protective Activities ofSolanum xanthocarpumRoot Extracts

(2013) Shashank Kumar et al.   Vegetos

The polyphenolic-rich Aronia melanocarpa juice kills teratocarcinomal cancer stem-like cells, but not their differentiated counterparts

(2013) Tanveer Sharif et al.   Journal of Functional Foods

Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms

(2013) Athanasios Valavanidis et al.   International Journal of Environmental Research and Public Health

Flavonoids in Cancer Prevention

(2012) Eun-Jung Park et al.   Anti-Cancer Agents in Medicinal Chemistry

Phytochemical Antioxidants Modulate Mammalian Cellular Epigenome: Implications in Health and Disease

(2012) Smitha Malireddy et al.   ANTIOXIDANTS & REDOX SIGNALING

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

(2012) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

(2012) Marcel Deponte   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting the Epigenome with Bioactive Food Components for Cancer Prevention

(2012) Thomas Prates Ong et al.   Journal of Nutrigenetics and Nutrigenomics

Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomes

(2012) Wim Vanden Berghe   PHARMACOLOGICAL RESEARCH

Vitamin E Isoforms Differentially Regulate Intercellular Adhesion Molecule-1 Activation of PKCα in Human Microvascular Endothelial Cells

(2012) Hiam Abdala-Valencia et al.   PLoS One

Roles of antioxidant enzymes in corpus luteum rescue from reactive oxygen species-induced oxidative stress

(2012) Kaïs H. Al-Gubory et al.   REPRODUCTIVE BIOMEDICINE ONLINE

7,3′,4′-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species

(2012) Yu-Li Lo et al.   TOXICOLOGY

Isoforms of Vitamin E Differentially Regulate Inflammation

(2012) Joan M. Cook-Mills et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα

(2011) Christine A. McCary et al.   BIOCHEMICAL JOURNAL

PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis

(2011) Reto Guler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antioxidant and prooxidant properties of flavonoids

(2011) D. Procházková et al.   FITOTERAPIA

Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells

(2011) Kyu Kim   INTERNATIONAL JOURNAL OF ONCOLOGY

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

(2011) Mahmoud Alhosin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Supplemental and Highly Elevated Tocopherol Doses Differentially Regulate Allergic Inflammation: Reversibility of  -Tocopherol and  -Tocopherol's Effects

(2011) C. A. McCary et al.   JOURNAL OF IMMUNOLOGY

Vitamin E ameliorates ox-LDL-induced foam cells formation through modulating the activities of oxidative stress-induced NF-κB pathway

(2011) Zhi-Gang Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

(2011) Praveen Rajendran et al.   Clinical Epigenetics

Allergy Risk Is Mediated by Dendritic Cells with Congenital Epigenetic Changes

(2010) Alexey V. Fedulov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

(2010) Joan M. Cook-Mills et al.   ANTIOXIDANTS & REDOX SIGNALING

The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention

(2010) Joshua D. Lambert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells

(2010) Srabanti Rakshit et al.   BIOCHEMICAL PHARMACOLOGY

Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells

(2010) Jin Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Selective activation of specific PKC isoforms dictating the fate of CD14+ monocytes towards differentiation or apoptosis

(2010) Yuan-Feng Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intracellular GSH Depletion Triggered Mitochondrial Bax Translocation to Accomplish Resveratrol-Induced Apoptosis in the U937 Cell Line

(2010) P. Guha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mulberry Fruit (Moris fructus) Extracts Induce Human Glioma Cell Death In Vitro Through ROS-Dependent Mitochondrial Pathway and Inhibits Glioma Tumor Growth In Vivo

(2010) Ji Cheon Jeong et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

PKCδ-Induced PU.1 Phosphorylation Promotes Hematopoietic Stem Cell Differentiation to Dendritic Cells

(2010) Matthias Hamdorf et al.   STEM CELLS

Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway

(2009) S. Jin et al.   ANNALS OF ONCOLOGY

PKC-α controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells

(2009) Christelle Langlet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression

(2009) Matthew R. Farren et al.   IMMUNOLOGIC RESEARCH

The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression

(2009) Betul Catalgol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment

(2009) S. Berdnikovs et al.   JOURNAL OF IMMUNOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Biosynthesis, regulation and functions of tocochromanols in plants

(2009) Laurent Mène-Saffrané et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression

(2009) Sophie Belin et al.   PLoS One

REVIEW ARTICLE: Maternal Transmission of Asthma Risk

(2008) Robert H. Lim et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Redox-Based Therapeutics for Lung Diseases

(2008) Yuma Hoshino et al.   ANTIOXIDANTS & REDOX SIGNALING

House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells

(2008) Ji-Sook Lee et al.   CYTOKINE

Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

(2008) A. Ceriello   DIABETES CARE

Vitamin E dependent microRNA regulation in rat liver

(2008) Sonja Gaedicke et al.   FEBS LETTERS

Molecular targeting of the PKC-βinhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression

(2008) Donata Verdelli et al.   HEMATOLOGICAL ONCOLOGY

Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group

(2008) Motoki Iwasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA