Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities

(2019) Paul Daniel et al.   Frontiers in Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015

(2018) Quinn T Ostrom et al.   NEURO-ONCOLOGY

BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF‑κB/MGMT signaling pathway

(2017) Mao Li et al.   Oncology Letters

Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression

(2017) Jing Hu et al.   Redox Biology

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I

(2016) Longmei Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Differences in protein expression between the u251 and u87 cell lines

(2016) Songtao Qi et al.   Turkish Neurosurgery

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

(2016) Chao Zhang et al.   PLoS One

Molecular mechanisms of Polyphyllin I-induced apoptosis and reversal of the epithelial–mesenchymal transition in human osteosarcoma cells

(2015) Junli Chang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells

(2015) Ya-Min Shi et al.   PHYTOMEDICINE

Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with ApoptosisIn VitroandIn Vivo

(2015) Zhufen Lin et al.   PHYTOTHERAPY RESEARCH

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

(2015) L Wei et al.   Cell Death & Disease

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer

(2015) Dong-Xu He et al.   Oncotarget

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

(2014) P Makhov et al.   BRITISH JOURNAL OF CANCER

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Polyphyllin D Induces Apoptosis in U87 Human Glioma Cells Through the c-Jun NH2-Terminal Kinase Pathway

(2014) Qiang Yu et al.   JOURNAL OF MEDICINAL FOOD

Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells

(2014) LEI FAN et al.   Molecular Medicine Reports

TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway

(2014) L-H Zhang et al.   ONCOGENE

Understanding high grade glioma: Molecular mechanism, therapy and comprehensive management

(2013) Yongzhi Wang et al.   CANCER LETTERS

Central Diabetes Insipidus: A Previously Unreported Side Effect of Temozolomide

(2013) Alexander T. Faje et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas

(2013) C-H Fan et al.   Cell Death & Disease

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A clinical review of treatment outcomes in glioblastoma multiforme—the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?

(2012) K Rock et al.   BRITISH JOURNAL OF RADIOLOGY

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L.

(2012) Zhen Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

(2011) C. T. Shearn et al.   MOLECULAR PHARMACOLOGY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

(2009) Jennifer A. Quinn et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

(2008) J. N. Sarkaria et al.   CLINICAL CANCER RESEARCH

Antifungal Saponins fromParis polyphyllaSmith

(2008) Dawei Deng et al.   PLANTA MEDICA