Tumor glycolysis, an essential sweet tooth of tumor cells

A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

(2022) Catherine S. Blaha et al.   Nature Communications

Taming metabolic competition via glycolysis inhibition for safe and potent tumor immunotherapy

(2022) Jun Lei et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

(2022) Sylvain Delaunay et al.   NATURE

Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter

(2022) Danielle L. Schmitt et al.   Nature Communications

SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism

(2022) Guohao Cai et al.   Scientific Reports

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors

(2022) Trinh-Le-Vi Kieu et al.   Cell Death & Disease

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer

(2021) Yinan Xiao et al.   ONCOGENE

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

(2021) Mylène Tajan et al.   Nature Communications

Mitochondrial dynamics in cancer stem cells

(2021) Dane T. Sessions et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

(2021) Radha Mukherjee et al.   MOLECULAR CELL

Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers

(2021) Tian-Jian Yu et al.   MOLECULAR THERAPY

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

(2021) Hiroshi Kondo et al.   Cell Reports

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

(2021) Xun Shangguan et al.   Nature Communications

Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α

(2021) Nives Škorja Milić et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer

(2021) Ritesh K. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex

(2021) Liang Zhang et al.   Cell Death & Disease

Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives

(2021) Natalia E. Cortez et al.   Nutrients

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

(2021) Shen-Han Lee et al.   Cells

A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

(2021) Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Heparanase Regulatory Network in Health and Disease

(2021) Alyce J. Mayfosh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

(2021) Minfeng Ying et al.   Redox Biology

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

(2020) Eric C. Cheung et al.   CANCER CELL

Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

(2020) Qiong Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?

(2020) Albert M. Li et al.   CANCER LETTERS

Role of Mitochondria in Cancer Stem Cell Resistance

(2020) José Manuel García-Heredia et al.   Cells

Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy

(2020) Saleha Anwar et al.   Biomedicines

Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells

(2020) Ahmed Ghdhban Al-Ziaydi et al.   Cancer Cell International

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

(2020) Zhen Cai et al.   MOLECULAR CELL

A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC

(2020) Mengyao Xu et al.   Journal of Molecular Cell Biology

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

(2020) Yu Chen Feng et al.   Nature Communications

Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment

(2020) Hitoshi Endo et al.   Redox Biology

Pyruvate Kinase M2 Coordinates Metabolism Switch between Glycolysis and Glutaminolysis in Cancer Cells

(2020) Liangwei Li et al.   iScience

The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity

(2020) Jaehyoun Lee et al.   PLoS One

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

(2020) William J. Quinn et al.   Cell Reports

In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

(2020) Wilson I. Gonsalves et al.   Cancer & Metabolism

Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis

(2020) Mengzhu Zheng et al.   PHARMACOLOGICAL RESEARCH

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells

(2019) Alexander Fabian et al.   CANCER LETTERS

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

The Mitochondrion as an Emerging Therapeutic Target in Cancer

(2019) Katherine G. Roth et al.   TRENDS IN MOLECULAR MEDICINE

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer

(2019) Nan Jin et al.   Nature Communications

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers

(2019) Hailing Yang et al.   CLINICAL CANCER RESEARCH

PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

(2019) Xu Qian et al.   MOLECULAR CELL

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

(2019) Jianshuang Guo et al.   Frontiers in Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Knock-down of PSAT1 Enhances Sensitivity of NSCLC Cells to Glutamine-limiting Conditions

(2019) HYEON-OK JIN et al.   ANTICANCER RESEARCH

Structure and mechanisms of ROS generation by NADPH oxidases

(2019) Francesca Magnani et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Aberrant FGFR tyrosine kinase signaling enhances the Warburg effect by reprogramming LDH isoform expression and activity in prostate cancer

(2018) Junchen Liu et al.   CANCER RESEARCH

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

(2018) Xianmin Mu et al.   CELL CYCLE

Targeting cancer metabolism to develop human lactate dehydrogenase ( h LDH)5 inhibitors

(2018) Shao-Lin Zhang et al.   DRUG DISCOVERY TODAY

Warburg effect, Lactate Dehydrogenase and Radio/Chemo-therapy efficacy

(2018) Michael I. Koukourakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

(2018) Cheng-Yang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

(2018) Jong-Ho Lee et al.   MOLECULAR CELL

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo

(2018) Luigi Mele et al.   Cell Death & Disease

Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway

(2018) Jie Wei et al.   Cell Death & Disease

Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Generation of hydroxyl radicals from reactions between a dimethoxyhydroquinone and iron oxide nanoparticles

(2018) Gry Lyngsie et al.   Scientific Reports

The Role of Mitochondrial H+-ATP Synthase in Cancer

(2018) Pau B. Esparza-Moltó et al.   Frontiers in Oncology

Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway

(2018) Ping Yang et al.   CANCER LETTERS

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response

(2018) Inna Serganova et al.   PLoS One

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

(2018) Xiaoyue Zhao et al.   Scientific Reports

The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

(2018) Anuradha Tarafdar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression

(2018) Na Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

(2018) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

(2018) Yangbo Feng et al.   Cancer Medicine

Pyruvate kinase M knockdown–induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival

(2017) Gopinath Prakasam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

(2017) Wei Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

(2017) L Jin et al.   ONCOGENE

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials

(2017) Amir Zahra et al.   RADIATION RESEARCH

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

(2017) Yapeng Ji et al.   Nature Communications

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

(2017) Jong-Ho Lee et al.   Nature Communications

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

(2017) Nam Hee Kim et al.   Nature Communications

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

(2017) Karthigayan Shanmugasundaram et al.   Nature Communications

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Lactate stimulates CA IX expression in normoxic cancer cells

(2017) Elena Panisova et al.   Oncotarget

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

(2017) Davinder Singh et al.   Cell and Bioscience

The Glycolytic Switch in Tumors: How Many Players Are Involved?

(2017) Li Yu et al.   Journal of Cancer

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

(2016) Jonathan L. Coloff et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

(2016) Bingyan Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression

(2016) Kaiyan Liu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

(2016) Edouard Mullarky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

(2016) Yaqing Li et al.   Oncotarget

Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma

(2016) Julia Herzog et al.   Oncotarget

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

(2016) Paloma Navarro et al.   Cell Reports

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

(2016) Elizabeth Allen et al.   Cell Reports

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

(2016) Laura Pisarsky et al.   Cell Reports

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

(2016) Roberta Palorini et al.   PLoS Genetics

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro

(2015) Ke Wang et al.   ANTI-CANCER DRUGS

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

(2015) Linchong Sun et al.   CELL RESEARCH

Heparan Sulphate as a Regulator of Leukocyte Recruitment in Inflammation

(2015) Archana Kumar et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer

(2015) Tian-Lin He et al.   MEDICAL ONCOLOGY

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

(2015) Rebecca Lamb et al.   Oncotarget

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

(2015) Jason Chesney et al.   Oncotarget

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

(2014) M I Koukourakis et al.   BRITISH JOURNAL OF CANCER

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

[18F](2S,4S)-4-(3-Fluoropropyl)glutamine as a Tumor Imaging Agent

(2014) Zehui Wu et al.   MOLECULAR PHARMACEUTICS

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

(2014) C R R Rocha et al.   Cell Death & Disease

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

(2014) Takehiro Yamamoto et al.   Nature Communications

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

(2013) Noel A Warfel et al.   CELL CYCLE

GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death

(2013) M A Jacquin et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

(2013) A. Nasi et al.   JOURNAL OF IMMUNOLOGY

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization

(2013) Lei Lv et al.   MOLECULAR CELL

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

Sirt3 is a tumor suppressor in lung adenocarcinoma cells

(2013) KUI XIAO et al.   ONCOLOGY REPORTS

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer

(2012) L. Jerby et al.   CANCER RESEARCH

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas

(2012) M. L. McCleland et al.   CLINICAL CANCER RESEARCH

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

HIF1α Protein Stability Is Increased by Acetylation at Lysine 709

(2012) Hao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyceraldehyde-3-Phosphate, a Glycolytic Intermediate, Prevents Cells from Apoptosis by Lowering S-Nitrosylation of Glyceraldehyde-3-Phosphate Dehydrogenase

(2012) Sun Young Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation

(2012) Jie Jia et al.   MOLECULAR CELL

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer

(2012) SEULHEE HAN et al.   Oncology Letters

The structure and allosteric regulation of mammalian glutamate dehydrogenase

(2011) Ming Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA

(2011) Christopher M. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt2 Kinase Suppresses Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH)-mediated Apoptosis in Ovarian Cancer Cells via Phosphorylating GAPDH at Threonine 237 and Decreasing Its Nuclear Translocation

(2011) Qiaojia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of aminotransferases in glutamate metabolism of human erythrocytes

(2011) James J. Ellinger et al.   JOURNAL OF BIOMOLECULAR NMR

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

(2011) Minsuh Seo et al.   PLoS One

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

(2011) Stefan Langhammer et al.   Targeted Oncology

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis

(2010) Steffen Heeg et al.   CANCER SCIENCE

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice

(2010) Tiago C. Leite et al.   FEBS LETTERS

Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle

(2010) Takeshi Baba et al.   FEBS LETTERS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinoma

(2010) Sara Rodríguez-Enríquez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The structure and allosteric regulation of glutamate dehydrogenase

(2010) Ming Li et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paraquat Exposure Induces Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and the Activation of the Nitric Oxide-GAPDH-Siah Cell Death Cascade

(2010) Miguel A. Ortiz-Ortiz et al.   TOXICOLOGICAL SCIENCES

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma

(2009) Mee-Kyung Cha et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell Extracts

(2009) Yonit Kasherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1  and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia

(2009) J. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation

(2009) Nilkantha Sen et al.   NEURON

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity

(2008) Guilherme A. Spitz et al.   BIOCHEMICAL PHARMACOLOGY

An acidic extracellular pH induces Src kinase-dependent loss of β-catenin from the adherens junction

(2008) Kuo-Hsin Chen et al.   CANCER LETTERS

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance

(2008) Chun-Wun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

(2008) N Goldin et al.   ONCOGENE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA