Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

(2016) Sai Krishna Athuluri-Divakar et al.   CELL

Drug repurposing: a new front in the war against Staphylococcus aureus

(2016) Swetarka Das et al.   Future Microbiology

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

(2016) Hong Lin et al.   ACS Medicinal Chemistry Letters

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease

(2015) Bo-Kyoung Kim et al.   FEBS LETTERS

Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration

(2015) Jiaojiao He et al.   Scientific Reports

Hexokinase 2 as oncotarget.

(2015) Krushna C. Patra et al.   Oncotarget

Therapeutic Targeting of BRCA1-Mutated Breast Cancers with Agents That Activate DNA Repair

(2014) E. Alli et al.   CANCER RESEARCH

Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain

(2014) O. d. Lange et al.   NUCLEIC ACIDS RESEARCH

A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells

(2013) Minsoo Koh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

(2013) Cecilia Marini et al.   CELL CYCLE

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Glycolysis Back in the Limelight: Systemic Targeting of HK2 Blocks Tumor Growth

(2013) S. Ros et al.   Cancer Discovery

Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

(2012) Xingyu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression and role in glycolysis of human ADP-dependent glucokinase

(2012) Susan Richter et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

(2011) Irina N. Alimova et al.   CELL CYCLE

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial

(2010) Wendy S Atkin et al.   LANCET

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY