Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Exosome-mediated miR-222 transferring: An insight into NF-κB-mediated breast cancer metastasis

(2018) Jiaji Ding et al.   EXPERIMENTAL CELL RESEARCH

Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K/Akt pathway

(2018) Xiao Fu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior

(2018) Shyam K. Bandari et al.   MATRIX BIOLOGY

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer

(2018) Qihan Fu et al.   ONCOGENE

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer

(2018) Alberto Checa-Rojas et al.   Oncotarget

Exosome-mediated breast cancer chemoresistance via miR-155 transfer

(2018) Juliana Carvalho Santos et al.   Scientific Reports

The emerging roles of exosomes in the modulation of immune responses in cancer

(2018) Paul Kurywchak et al.   Genome Medicine

The Origin and Functions of Exosomes in Cancer

(2018) Chitra Rajagopal et al.   Frontiers in Oncology

Extracellular vesicles from triple-negative breast cancer cells promote proliferation and drug resistance in non-tumorigenic breast cells

(2018) Patricia Midori Murobushi Ozawa et al.   BREAST CANCER RESEARCH AND TREATMENT

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma

(2018) Yoav Binenbaum et al.   CANCER RESEARCH

Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells

(2018) Nils Ludwig et al.   MOLECULAR CANCER RESEARCH

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer

(2017) Su-jin Yang et al.   GENE

Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance

(2017) Richard J. Lobb et al.   INTERNATIONAL JOURNAL OF CANCER

The role of exosomes and miRNAs in drug-resistance of cancer cells

(2017) Duc-Hiep Bach et al.   INTERNATIONAL JOURNAL OF CANCER

Cisplatin-resistant lung cancer cell–derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100–5p-dependent manner

(2017) Xiaobing Qin et al.   International Journal of Nanomedicine

UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer

(2017) Kuan Ning et al.   JOURNAL OF SURGICAL ONCOLOGY

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

(2017) Feng Wei et al.   Molecular Cancer

Smuggling gold nanoparticles across cell types – A new role for exosomes in gene silencing

(2017) Catarina Roma-Rodrigues et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma

(2017) A-L Zeng et al.   ONCOGENE

Glioblastoma Exosomes for Therapeutic Angiogenesis in Peripheral Ischemia

(2017) Anthony Monteforte et al.   TISSUE ENGINEERING PART A

Exosomes as mediators of platinum resistance in ovarian cancer

(2017) Jennifer Crow et al.   Oncotarget

Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle–Associated PDGFRβ

(2017) Laura J. Vella et al.   NEOPLASIA

Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles

(2017) Vanesa G. Martinez et al.   OncoImmunology

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

(2017) Theresa L. Whiteside   Translational Cancer Research

Integrins and Exosomes, a Dangerous Liaison in Cancer Progression

(2017) et al.   Cancers

Anti-tumour activity of tivozanib, a pan-inhibitor of VEGF receptors, in therapy-resistant ovarian carcinoma cells

(2017) Majid Momeny et al.   Scientific Reports

Exosome-mediated microenvironment dysregulation in leukemia

(2016) Bijender Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Exosomes in developmental signalling

(2016) Ian John McGough et al.   DEVELOPMENT

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Nano carriers for drug transport across the blood–brain barrier

(2016) Xinming Li et al.   JOURNAL OF DRUG TARGETING

Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

(2016) Li Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

(2016) K E Richards et al.   ONCOGENE

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PLK-1 Silencing in Bladder Cancer by siRNA Delivered With Exosomes

(2016) Kristin A. Greco et al.   UROLOGY

Microvesicle removal of anticancer drugs contributes to drug resistance in human pancreatic cancer cells

(2016) Vandhana Muralidharan-Chari et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting

(2016) Bing Lu et al.   Frontiers in Pharmacology

Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis

(2015) Yiwen You et al.   CANCER SCIENCE

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

(2015) Mian He et al.   CARCINOGENESIS

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

New Findings on Breast Cancer Stem Cells: A Review

(2015) Azam Bozorgi et al.   Journal of Breast Cancer

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Glioma-derived extracellular vesicles selectively suppress immune responses

(2015) Justin E. Hellwinkel et al.   NEURO-ONCOLOGY

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

(2015) F J Kohlhapp et al.   ONCOGENE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes

(2015) C A Franzen et al.   Oncogenesis

Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness

(2015) Wei Mu et al.   NEOPLASIA

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Regulation of exosome release from mammary epithelial and breast cancer cells – A new regulatory pathway

(2014) Andrew Riches et al.   EUROPEAN JOURNAL OF CANCER

Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

(2014) Soheila Sharghi-Namini et al.   Scientific Reports

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Exosomes

(2013) Huang-Ge Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review

(2013) Asfar S. Azmi et al.   CANCER AND METASTASIS REVIEWS

Pathogenic role of Epstein–Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma

(2013) Tomokazu Yoshizaki et al.   CANCER LETTERS

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

(2013) Christin Bissig et al.   DEVELOPMENTAL CELL

Therapeutics targeting angiogenesis: Genetics and epigenetics, extracellular miRNAs and signaling networks (Review)

(2013) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

(2013) Chiara Corrado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes: Looking back three decades and into the future

(2013) Clifford V. Harding et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors

(2013) Dennis Kjølhede Jeppesen et al.   PROTEOMICS

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC

(2011) Christina Battke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between

(2011) Markus Babst   CURRENT OPINION IN CELL BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The basics of epithelial-mesenchymal transition

(2011) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Mechanisms and Function of Dendritic Exocytosis

(2011) Matthew J. Kennedy et al.   NEURON

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

(2010) Xuefeng Ren et al.   EMBO JOURNAL

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis

(2010) An Hendrix et al.   JNCI-Journal of the National Cancer Institute

Anti-Apoptotic Mechanisms of Drug Resistance in Cancer

(2009) T. Wilson et al.   CURRENT CANCER DRUG TARGETS

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

(2009) R. A. Neumuller et al.   GENES & DEVELOPMENT

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen

(2008) Anton Poliakov et al.   PROSTATE

Angiogenesis as a strategic target for ovarian cancer therapy

(2008) Whitney A Spannuth et al.   Nature clinical practice. Oncology