Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

(2020) Eduardo Balsa et al.   Nature Communications

Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis

(2020) Jonathan M. Ghergurovich et al.   CANCER RESEARCH

Wild‑type IDH1 affects cell migration by modulating the PI3K/AKT/mTOR pathway in primary glioblastoma cells

(2020) Xiaopeng Shen et al.   Molecular Medicine Reports

Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

(2020) Chang Shao et al.   Redox Biology

Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?

(2020) Cindy Mendes et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The quantitative relationship between isotopic and net contributions of lactate and glucose to the TCA cycle

(2019) Minfeng Ying et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of isocitrate dehydrogenases expression and activity by the androgen receptor in prostate cancer

(2019) Kevin Gonthier et al.   MOLECULAR CANCER RESEARCH

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Boosting NAD+ with a small molecule that activates NAMPT

(2019) Stephen J. Gardell et al.   Nature Communications

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

(2019) Yahui Zhu et al.   MOLECULAR CELL

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis

(2018) Yun-Xin Lu et al.   CANCER RESEARCH

Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma

(2018) Chie Nakashima et al.   CANCER SCIENCE

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

(2018) Russell P. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

(2018) Xiao-xue Li et al.   MOLECULAR CELL

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

(2018) Seungyeon Yang et al.   Cell Death & Disease

Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

(2018) Lorenzo M. Fernandes et al.   Scientific Reports

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

(2017) Takeo Goji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Basis for Deuterium Labeling of Fat and NADPH

(2017) Zhaoyue Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

(2017) Rongkun Tao et al.   NATURE METHODS

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

(2017) Andrea E. Calvert et al.   Cell Reports

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

(2016) Daniel R. Wahl et al.   CANCER RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

(2016) Yi-Ping Wang et al.   MOLECULAR CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis

(2016) Ming Chao et al.   eLife

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

(2015) Ujunwa C Okoye-Okafor et al.   Nature Chemical Biology

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Beyond Warburg effect – dual metabolic nature of cancer cells

(2014) Jiansheng Xie et al.   Scientific Reports

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death

(2011) Hao Wu et al.   JOURNAL OF PATHOLOGY

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells

(2010) P. Huypens et al.   DIABETOLOGIA

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE