Taming metabolic competition via glycolysis inhibition for safe and potent tumor immunotherapy

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

(2019) Changliang Shan et al.   Cell Death & Disease

Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms

(2019) Petros Fessas et al.   IMMUNOLOGY

Regulation of glucose and lipid metabolism in health and disease

(2019) Ligong Chen et al.   Science China-Life Sciences

Management of pulmonary toxicity associated with immune checkpoint inhibitors

(2019) Myriam Delaunay et al.   European Respiratory Review

Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer

(2019) Cristina Gutierrez et al.   CRITICAL CARE MEDICINE

Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma

(2018) Binghao Li et al.   CANCER RESEARCH

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Regulation of T cell immunity by cellular metabolism

(2018) Zhilin Hu et al.   Frontiers of Medicine

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

(2016) Yichao Chen et al.   Nature Communications

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

(2016) Ralf A. Linker et al.   Therapeutic Advances in Chronic Disease

Crystal Structures of Group B Streptococcus Glyceraldehyde-3-Phosphate Dehydrogenase: Apo-Form, Binary and Ternary Complexes

(2016) Norbert Schormann et al.   PLoS One

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

The IL-2 cytokine family in cancer immunotherapy

(2014) Geok Choo Sim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Warburg effect: Insights from the past decade

(2012) Mohita Upadhyay et al.   PHARMACOLOGY & THERAPEUTICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

(2011) Wei-Ting Hwang et al.   GYNECOLOGIC ONCOLOGY

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

(2011) Sahar M.A. Mahmoud et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Warburg phenotype in renal cell carcinoma: High expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltration in the tumor

(2010) Katrin Singer et al.   INTERNATIONAL JOURNAL OF CANCER

Crystal Structure of Glyceraldehyde-3-Phosphate Dehydrogenase 1 from Methicillin-Resistant Staphylococcus aureus MRSA252 Provides Novel Insights into Substrate Binding and Catalytic Mechanism

(2010) Somnath Mukherjee et al.   JOURNAL OF MOLECULAR BIOLOGY

An unexpected phosphate binding site in Glyceraldehyde 3-Phosphate Dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme

(2009) William J Cook et al.   BMC STRUCTURAL BIOLOGY

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Trapping of the Thioacylglyceraldehyde-3-phosphate Dehydrogenase Intermediate fromBacillus stearothermophilus

(2008) Sébastien Moniot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology