Lactate Limits T Cell Proliferation via the NAD(H) Redox State

SLC25A51 is a mammalian mitochondrial NAD+ transporter

(2020) Timothy S. Luongo et al.   NATURE

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

(2019) Eros Marin et al.   Cell Metabolism

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Placental physiology monitored by hyperpolarized dynamic13C magnetic resonance

(2018) Stefan Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Store-Operated Ca 2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

(2017) Martin Vaeth et al.   IMMUNITY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Mitochondrial matrix pH as a decisive factor in neurometabolic imaging

(2017) Patrick M. Schaefer et al.   Neurophotonics

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Post-Transplant Diabetes Mellitus: Causes, Treatment, and Impact on Outcomes

(2016) Vijay Shivaswamy et al.   ENDOCRINE REVIEWS

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

HDAC5 controls the functions of Foxp3+ T-regulatory and CD8+ T cells

(2016) Haiyan Xiao et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Sirtuin-1 prolongs murine renal allograft survival and function

(2016) Matthew H. Levine et al.   KIDNEY INTERNATIONAL

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

The contributions of respiration and glycolysis to extracellular acid production

(2015) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

Calcineurin Inhibitor Nephrotoxicity

(2009) M. Naesens et al.   Clinical Journal of the American Society of Nephrology