Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma

(2016) Shan Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

(2016) Juan Li et al.   NEUROREPORT

RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis

(2016) G N Alesi et al.   ONCOGENE

Identification of TargetableERBB2Aberrations in Head and Neck Squamous Cell Carcinoma

(2016) Andrew C. Birkeland et al.   JAMA Otolaryngology-Head & Neck Surgery

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Inhibition of LDHA suppresses tumor progression in prostate cancer

(2015) Zhi-Yong Xian et al.   TUMOR BIOLOGY

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

Relationships between LDH-A, Lactate, and Metastases in 4T1 Breast Tumors

(2013) A. Rizwan et al.   CLINICAL CANCER RESEARCH

Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy

(2013) Ping Miao et al.   IUBMB LIFE

The Prometastatic Ribosomal S6 Kinase 2-cAMP Response Element-binding Protein (RSK2-CREB) Signaling Pathway Up-regulates the Actin-binding Protein Fascin-1 to Promote Tumor Metastasis

(2013) Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

p90 RSK2 Mediates Antianoikis Signals by both Transcription-Dependent and -Independent Mechanisms

(2013) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

(2013) Taro Hitosugi et al.   Nature Communications

A Phase II Study of Lapatinib in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

(2012) J. A. de Souza et al.   CLINICAL CANCER RESEARCH

c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

(2012) L. P. Stabile et al.   CLINICAL CANCER RESEARCH

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

(2011) M. Zhao et al.   CLINICAL CANCER RESEARCH

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells

(2010) Sumin Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Epithelial to mesenchymal transition in head and neck squamous carcinoma

(2008) Mahitosh Mandal et al.   CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Recent Advances in Head and Neck Cancer

(2008) Robert I. Haddad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hyaluronidases in cancer biology

(2008) Robert Stern   SEMINARS IN CANCER BIOLOGY