Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages 8610
Publisher
MDPI AG
Online
2021-08-11
DOI
10.3390/ijms22168610
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTOR at the nexus of nutrition, growth, ageing and disease
- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells
- (2020) Sergej Pirkmajer et al. Frontiers in Physiology
- Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab
- (2019) Dawei Wang et al. ONCOGENE
- Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations
- (2019) Maruša Bizjak et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Increased Pyruvate Dehydrogenase Activity in Skeletal Muscle of Growth Restricted Ovine Fetuses
- (2019) Alexander L. Pendleton et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis
- (2018) Justin Goodwin et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling
- (2018) Bingbing Li et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Training state and fasting-induced PDH regulation in human skeletal muscle
- (2018) Anders Gudiksen et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Effects of training status on PDH regulation in human skeletal muscle during exercise
- (2017) Anders Gudiksen et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions
- (2017) Swatishree Sradhanjali et al. PLoS One
- Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
- (2017) Evangelos D. Michelakis et al. Science Translational Medicine
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells
- (2017) Nathan P. Ward et al. PLoS One
- Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro
- (2017) Maruša Bizjak et al. Scientific Reports
- Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability
- (2016) Clair Crewe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis
- (2016) Xinjian Li et al. MOLECULAR CELL
- Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells
- (2016) Bo Li et al. Oncotarget
- The ERK signaling target RNF126 regulates anoikis resistance in cancer cells by changing the mitochondrial metabolic flux
- (2016) Seiko Yoshino et al. Cell Discovery
- Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells
- (2016) Maruša Rajh et al. PLoS One
- siRNA delivery into cultured primary human myoblasts - optimization of electroporation parameters and theoretical analysis
- (2015) Jasna Lojk et al. BIOELECTROMAGNETICS
- Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells
- (2015) Nelson Ho et al. EXPERIMENTAL CELL RESEARCH
- Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy
- (2015) Helena Pópulo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?
- (2015) Wen Zhang et al. International Journal of Biological Sciences
- The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents
- (2015) Elise Saunier et al. INTERNATIONAL JOURNAL OF CANCER
- New roles for mitochondrial proteases in health, ageing and disease
- (2015) Pedro M. Quirós et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes
- (2015) Adrian Westhaus et al. NEUROCHEMICAL RESEARCH
- Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
- (2015) Xinke Zhou et al. Oncotarget
- Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism
- (2015) Fabian Fischer et al. Scientific Reports
- Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition
- (2014) S. Piel et al. Acta Physiologica
- Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism
- (2014) M. E. Lindholm et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells
- (2014) Allison B. Haugrud et al. BREAST CANCER RESEARCH AND TREATMENT
- Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells
- (2014) Yong Won Choi et al. CANCER LETTERS
- Increased pyruvate dehydrogenase kinase expression in cultured myotubes from obese and diabetic individuals
- (2014) A. J. McAinch et al. EUROPEAN JOURNAL OF NUTRITION
- PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade
- (2014) Zhibo Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
- (2013) K. K. Velpula et al. CANCER RESEARCH
- Mitochondrial matrix proteases as novel therapeutic targets in malignancy
- (2013) C A Goard et al. ONCOGENE
- Two Weeks of Metformin Treatment Enhances Mitochondrial Respiration in Skeletal Muscle of AMPK Kinase Dead but Not Wild Type Mice
- (2013) Jonas M. Kristensen et al. PLoS One
- Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes
- (2013) Rongya Tao et al. PLoS One
- Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling
- (2013) F Gong et al. Cell Death & Disease
- Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
- (2013) Dumitru Constantin-Teodosiu Diabetes & Metabolism Journal
- Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer
- (2012) G Sutendra et al. ONCOGENE
- Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
- (2011) Y. Zhao et al. CANCER RESEARCH
- HIF-1α response to hypoxia is functionally separated from the glucocorticoid stress response in the in vitro regenerating human skeletal muscle
- (2010) Sergej Pirkmajer et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells
- (2010) Ulrika Krus et al. BIOCHEMICAL JOURNAL
- Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
- (2010) B M Madhok et al. BRITISH JOURNAL OF CANCER
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
- (2009) Ramon C. Sun et al. BREAST CANCER RESEARCH AND TREATMENT
- The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
- (2009) S. A. Bustin et al. CLINICAL CHEMISTRY
- Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
- (2009) J. M. Ruijter et al. NUCLEIC ACIDS RESEARCH
- Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase
- (2008) Azmi Yerlikaya et al. BIOCHEMICAL JOURNAL
- PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
- (2008) S M Wigfield et al. BRITISH JOURNAL OF CANCER
- Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells
- (2008) Thomas McFate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Different Effect of Proteasome Inhibition on Vesicular Stomatitis Virus and Poliovirus Replication
- (2008) Nickolay Neznanov et al. PLoS One
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started