Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization

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Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

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Targeting metastasis-initiating cells through the fatty acid receptor CD36

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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

(2016) Akash Kumar et al.   NATURE MEDICINE

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Targeting metabolic reprogramming as a potential therapeutic strategy in melanoma

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A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

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Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts

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Fundamentals of cancer metabolism

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Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

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Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

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Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer

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AKT and cytosolic phospholipase A2α form a positive loop in prostate cancer cells

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Trends in Management for Patients With Localized Prostate Cancer, 1990-2013

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Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

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Linking obesogenic dysregulation to prostate cancer progression

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Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

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Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells

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A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

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A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

(2014) Stuart J Ellem et al.   JOURNAL OF PATHOLOGY

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

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Copy number alteration burden predicts prostate cancer relapse

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Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

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Punctuated Evolution of Prostate Cancer Genomes

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Cellular Fatty Acid Metabolism and Cancer

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Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery

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A preclinical xenograft model of prostate cancer using human tumors

(2013) Mitchell G Lawrence et al.   Nature Protocols

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

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Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

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Fat Intake After Diagnosis and Risk of Lethal Prostate Cancer and All-Cause Mortality

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Dietary Fatty Acid Intake and Prostate Cancer Survival in Orebro County, Sweden

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Obesity and Prostate Cancer: Weighing the Evidence

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CD36 Protein Influences Myocardial Ca2+Homeostasis and Phospholipid Metabolism

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The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

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Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments

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PTEN Level in Tumor Suppression: How Much Is Too Little?

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Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

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CD36 Protein Is Involved in Store-operated Calcium Flux, Phospholipase A2 Activation, and Production of Prostaglandin E2

(2011) Ondrej Kuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK

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Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY