Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma

(2015) Shanmugasundaram Ganapathy-Kanniappan et al.   Oncotarget

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

(2012) E Madan et al.   BRITISH JOURNAL OF CANCER

Myeloperoxidase Catalyzes the Conjugation of Serotonin to Thiols via Free Radicals and Tryptamine-4,5-dione

(2012) Yoji Kato et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Impact of Thawing on Reference Gene Expression Stability in Renal Cell Carcinoma Samples

(2012) Yi Ma et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

A novel miR-155/miR-143 cascade controls glycolysis by regulatinghexokinase 2in breast cancer cells

(2012) Shuai Jiang et al.   EMBO JOURNAL

Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-Bromopyruvate Propyl Ester

(2012) Zhenjie Tang et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

(2012) Simone Cardaci et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Human and Pneumococcal Cell Surface Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Proteins Are Both Ligands of Human C1q Protein

(2012) Rémi Terrasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-143 (miR-143) Regulates Cancer Glycolysis via Targeting Hexokinase 2 Gene

(2012) Rong Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular dynamics of multifunctional protein regulation: Mechanisms of GAPDH intracellular translocation

(2012) Michael A. Sirover   JOURNAL OF CELLULAR BIOCHEMISTRY

18F-FDG PET/CT Metabolic Tumor Volume and Total Lesion Glycolysis Predict Outcome in Oropharyngeal Squamous Cell Carcinoma

(2012) R. Lim et al.   JOURNAL OF NUCLEAR MEDICINE

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Growth Inhibition of Pancreatic Cancer by Experimental Treatment With 4-Phenylbutyrate Is Associated With Increased Expression of Connexin 43

(2012) Dmitriy I. Dovzhanskiy et al.   ONCOLOGY RESEARCH

Housekeeping Gene Selection Advisory: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and β-Actin Are Targets of miR-644a

(2012) Kavleen Sikand et al.   PLoS One

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component

(2012) C. Nicholls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer

(2011) Chun-Wun Lu et al.   AMERICAN JOURNAL OF PATHOLOGY

In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53

(2011) Mst. Thangima Zannat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models

(2011) Ana-Maria Marino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

(2011) Apirat Chaikuad et al.   BIOCHEMICAL JOURNAL

Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer

(2011) Jörg Ellinger et al.   CANCER INVESTIGATION

18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

(2011) N. Palaskas et al.   CANCER RESEARCH

Molecular Mechanism of Glyceraldehyde-3-phosphate Dehydrogenase Inactivation by α,β-Unsaturated Carbonyl Derivatives

(2011) Christopher J. Martyniuk et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Reference Genes for Gene Expression Analysis by Real-time Reverse Transcription Polymerase Chain Reaction of Renal Cell Carcinoma

(2011) Henriette Bjerregaard et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Reference gene validation for qPCR on normoxia- and hypoxia-cultured human dermal fibroblasts exposed to UVA: Is β-actin a reliable normalizer for photoaging studies?

(2011) F. Brugè et al.   JOURNAL OF BIOTECHNOLOGY

Glucose transporter and hypoxia-associated gene expression in the mammary gland of transition dairy cattle

(2011) S.A. Mattmiller et al.   JOURNAL OF DAIRY SCIENCE

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

(2011) María Sánchez-Aragó et al.   Journal of Translational Medicine

Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies

(2011) Camillo Rosano   MITOCHONDRION

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues

(2011) Raquel Guimarães Coelho et al.   MOLECULAR GENETICS AND METABOLISM

DiseaseMeth: a human disease methylation database

(2011) J. Lv et al.   NUCLEIC ACIDS RESEARCH

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection of reliable reference genes for gene expression study in nasopharyngeal carcinoma

(2010) Yi Guo et al.   ACTA PHARMACOLOGICA SINICA

Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production

(2010) María Fátima Ladelfa et al.   ANTIOXIDANTS & REDOX SIGNALING

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

(2010) Caroline Jose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of valid reference genes for gene expression studies of human stomach cancer by reverse transcription-qPCR

(2010) Hyun-Wook Rho et al.   BMC CANCER

dbDEMC: a database of differentially expressed miRNAs in human cancers

(2010) Zhen Yang et al.   BMC GENOMICS

Hypoxia regulates the production and activity of glucose transporter-1 and indoleamine 2,3-dioxygenase in monocyte-derived endothelial-like cells: possible relevance to infantile haemangioma pathogenesis

(2010) A. Herbert et al.   BRITISH JOURNAL OF DERMATOLOGY

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect

(2010) Aalim M. Weljie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

(2010) Katarína Smolková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures

(2010) John S. Tsang et al.   MOLECULAR CELL

Endogenous Activation of Glucokinase by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Is Glucose Dependent

(2010) Sara Langer et al.   MOLECULAR ENDOCRINOLOGY

New insights into the molecular mechanisms of classical complement activation

(2010) Mihaela Kojouharova et al.   MOLECULAR IMMUNOLOGY

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction

(2009) Yan-Li Li et al.   ANALYTICAL BIOCHEMISTRY

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reference gene selection for head and neck squamous cell carcinoma gene expression studies

(2009) Benjamin Lallemant et al.   BMC MOLECULAR BIOLOGY

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Altered sphingolipid metabolism induced by tumor hypoxia - New vistas in glycolipid tumor markers

(2009) Jun Yin et al.   FEBS LETTERS

Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

(2009) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation

(2009) Nilkantha Sen et al.   NEURON

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

(2009) Judith Favier et al.   PLoS One

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

(2009) Chunlei Wu et al.   GENOME BIOLOGY

Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR

(2008) Vito R Cicinnati et al.   BMC CANCER

Identification of Importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens

(2008) Paul A Nguewa et al.   BMC MOLECULAR BIOLOGY

HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence

(2008) Álvaro D. Ortega et al.   CARCINOGENESIS

Carrot and stick: HIF-α engages c-Myc in hypoxic adaptation

(2008) L E Huang   CELL DEATH AND DIFFERENTIATION

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Serum and Tissue LDH Levels in Patients with Breast/Gynaecological Cancer and Benign Diseases

(2008) Michael I. Koukourakis et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

The hTAFII68-TEC fusion protein functions as a strong transcriptional activator

(2008) Sol Kim et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of β-F1-ATPase and mitochondrial transcription factor A and the change in mitochondrial DNA content in colorectal cancer: clinical data analysis and evidence from an in vitro study

(2008) Pei-Ching Lin et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment’s roles together with hexokinase-2 in the “Warburg effect” in cancer

(2008) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance

(2008) Chun-Wun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selection of reference genes for real-time PCR in human hepatocellular carcinoma tissues

(2008) Qiang Gao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

The genetics of the p53 pathway, apoptosis and cancer therapy

(2008) Alexei Vazquez et al.   NATURE REVIEWS DRUG DISCOVERY

AS-ALPS: a database for analyzing the effects of alternative splicing on protein structure, interaction and network in human and mouse

(2008) M. Shionyu et al.   NUCLEIC ACIDS RESEARCH

Both β-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancer

(2008) Ryutaro Mori et al.   PROSTATE

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY