The Heparanase Regulatory Network in Health and Disease

MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase

(2021) Dorival Mendes Rodrigues-Junior et al.   OncoTargets and Therapy

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

(2021) Alex Agelidis et al.   JCI Insight

Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma

(2021) Xiaopeng Chen et al.   Cell Death Discovery

Heparanase modulation by Wingless/INT (Wnt)

(2021) Carina Mucciolo Melo et al.   MOLECULAR BIOLOGY REPORTS

Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers

(2021) Konstantina Karamanou et al.   Cells

Heparanase, cell signaling, and viral infections

(2020) Raghuram Koganti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heparanase-enhanced Shedding of Syndecan-1 and Its Role in Driving Disease Pathogenesis and Progression

(2020) Sunil Rangarajan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo

(2020) Xuan Huang et al.   Frontiers in Cell and Developmental Biology

Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19

(2020) Klaus Stahl et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Plasma Heparanase Activity in COVID-19 Patients

(2020) Baranca Buijsers et al.   Frontiers in Immunology

Heparanase and the hallmarks of cancer

(2020) Krishnath M. Jayatilleke et al.   Journal of Translational Medicine

Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells

(2019) Tianyi Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Heparanase accelerates obesity-associated breast cancer progression

(2019) Esther Hermano et al.   CANCER RESEARCH

Heparanase and Chemotherapy Synergize to Drive Macrophage Activation and Enhance Tumor Growth

(2019) Udayan Bhattacharya et al.   CANCER RESEARCH

Heparanase: A Challenging Cancer Drug Target

(2019) Deirdre R. Coombe et al.   Frontiers in Oncology

CTC clusters induced by heparanase enhance breast cancer metastasis

(2018) Rong-rui Wei et al.   ACTA PHARMACOLOGICA SINICA

Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells

(2018) Ekapot Singsuksawat et al.   Cancer Cell International

Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury

(2018) Valentina Masola et al.   FASEB JOURNAL

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

(2018) Hong-Ru Chen et al.   PLoS Pathogens

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

(2018) Qiongying Lv et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma

(2018) Shahid Shah et al.   Oncotarget

Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression

(2018) Li-Ping Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury

(2018) Valentina Masola et al.   Oncotarget

NK cell heparanase controls tumor invasion and immune surveillance

(2017) Eva M. Putz et al.   JOURNAL OF CLINICAL INVESTIGATION

Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents

(2017) Mayank Khanna et al.   JOURNAL OF GENERAL VIROLOGY

Involvement of the heparanase procoagulant domain in bleeding and wound healing

(2017) Y. Crispel et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heparanase Upregulation Contributes to Porcine Reproductive and Respiratory Syndrome Virus Release

(2017) Chunhe Guo et al.   JOURNAL OF VIROLOGY

Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation

(2017) Anqi Xiong et al.   MATRIX BIOLOGY

The Functions of Heparanase in Human Diseases

(2017) Hao Jin et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Effects of unfractionated heparin and rivaroxaban on the expression of heparanase and fibroblast growth factor 2 in human osteoblasts

(2017) Jingjun Xia et al.   Molecular Medicine Reports

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

(2017) Ton J. Rabelink et al.   Nature Reviews Nephrology

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545

(2017) Zaid Abassi et al.   Oncotarget

Heparanase and macrophage interplay in the onset of liver fibrosis

(2017) Maria Francesca Secchi et al.   Scientific Reports

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

(2017) Alex M. Agelidis et al.   Cell Reports

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

(2017) Yoan R. Monneau et al.   Open Biology

The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

(2017) Lukas Martin et al.   Frontiers in Immunology

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression

(2017) Preeti Singh et al.   NEOPLASIA

The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target

(2017) Iyad Khamaysi et al.   Scientific Reports

Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines

(2016) Naoki Tsunekawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells

(2016) Tobias Pasqualon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heparanase: From basic research to therapeutic applications in cancer and inflammation

(2016) Israel Vlodavsky et al.   DRUG RESISTANCE UPDATES

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype

(2016) Vishnu C. Ramani et al.   MATRIX BIOLOGY

Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria

(2016) Marjolein Garsen et al.   PLoS One

Heparanase is required for activation and function of macrophages

(2016) Lilach Gutter-Kapon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic ductal cell adenocarcinoma

(2016) BIN LV et al.   Oncology Letters

The prognostic significance of heparanase expression in metastatic melanoma

(2016) Olga Vornicova et al.   Oncotarget

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

(2016) Beatriz García et al.   Frontiers in Microbiology

Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis

(2015) Ning-Bo Hao et al.   CANCER LETTERS

Heparan Sulphate as a Regulator of Leukocyte Recruitment in Inflammation

(2015) Archana Kumar et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation

(2015) Liat Stoler-Barak et al.   FASEB JOURNAL

The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization

(2015) Douglas P Dyer et al.   GLYCOBIOLOGY

Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte

(2015) Marjolein Garsen et al.   JOURNAL OF PATHOLOGY

Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity

(2015) Y Yang et al.   ONCOGENE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis

(2015) Xinyang Hu et al.   STEM CELLS

The critical role of Akt in cardiovascular function

(2015) Prasanna Abeyrathna et al.   VASCULAR PHARMACOLOGY

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Targeting heparanase overcomes chemoresistance and diminishes relapse in myeloma

(2015) Vishnu C. Ramani et al.   Oncotarget

Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression

(2015) Bo Tang et al.   Oncotarget

FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells

(2015) Attaya Suvannasankha et al.   Oncotarget

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model

(2015) Adi Binder Gallimidi et al.   Oncotarget

Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells

(2015) Inger Øynebråten et al.   Scientific Reports

Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer

(2015) Lixin Zhang et al.   NEOPLASIA

Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor

(2015) Xiangbing Wu et al.   PLoS One

Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation

(2015) Geetha Rao et al.   NEOPLASIA

Heparanase expression and localization in different types of human lung cancer

(2014) Teresa Cristina Fernandes dos Santos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity

(2014) Valentina Masola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer

(2014) X Wang et al.   BRITISH JOURNAL OF CANCER

Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling

(2014) Philip L.S.M. Gordts et al.   Cell Metabolism

Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation

(2014) Ivan K. H. Poon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Methylation of Heparanase Promoter Influences Its Expression and Associated with the Progression of Human Breast Cancer

(2014) Fei Jiao et al.   PLoS One

Interference with Glycosaminoglycan-Chemokine Interactions with a Probe to Alter Leukocyte Recruitment and Inflammation In Vivo

(2014) Sandra Li et al.   PLoS One

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

(2013) Ding Xu et al.   ACS Chemical Biology

1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

(2013) Jennifer C. Wilson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dialysis-related transcriptomic profiling: The pivotal role of heparanase

(2013) Gianluigi Zaza et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP

(2013) O. Ostrovsky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heparan sulfate in the nucleus and its control of cellular functions

(2013) Mark D. Stewart et al.   MATRIX BIOLOGY

Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression

(2012) Miry Blich et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular characterization, expression profiles of the porcine SDC2 and HSPG2 genes and their association with hematologic parameters

(2012) Weimin Wang et al.   MOLECULAR BIOLOGY REPORTS

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

TNF-α induces early growth response gene-1 expression via ERK1/2 activation in endothelial cells

(2011) Yanli Cao et al.   ACTA DIABETOLOGICA

Activation of heparanase by ultraviolet B irradiation leads to functional loss of basement membrane at the dermal–epidermal junction in human skin

(2011) Shunsuke Iriyama et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Fatty Acid-Induced Nuclear Translocation of Heparanase Uncouples Glucose Metabolism in Endothelial Cells

(2011) Fang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mutual enhancement between heparanase and vascular endothelial growth factor: A novel mechanism for melanoma progression

(2011) Qi Luan et al.   CANCER LETTERS

MicroRNA-1258 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase

(2011) L. Zhang et al.   CANCER RESEARCH

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

(2011) N. Gil et al.   DIABETES

Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

(2011) G. Rao et al.   DIABETOLOGIA

Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

(2011) Valentina Masola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation

(2011) Victoria Cohen-Kaplan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Is Essential for High Mobility Group Protein 1 (HMGB1) Signaling by the Receptor for Advanced Glycation End Products (RAGE)

(2011) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systems Biology Approach for the Investigation of the Heparin/Heparan Sulfate Interactome

(2011) Alessandro Ori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype

(2011) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

(2011) Immanuel Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor

(2011) Xiao-Fei An et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Heparanase Modulation of Early Growth Response Gene Expression

(2011) Xia Yan et al.   ZOOLOGICAL SCIENCE

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

Retinal heparanase expression in streptozotocin-induced diabetic rats

(2010) Pingping Ma et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice

(2010) Xu-Dong Tang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization

(2010) Fang Wang et al.   CARDIOVASCULAR RESEARCH

Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

(2010) Flonia Levy-Adam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity

(2010) Vishnu C. Ramani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Proteins Indicating Radiation-induced Hepatic Toxicity in Cirrhotic Rats

(2010) Sook In CHUNG et al.   JOURNAL OF RADIATION RESEARCH

Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis

(2010) Menachem Bitan et al.   MOLECULAR IMMUNOLOGY

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The First Draft of the Endostatin Interaction Network

(2009) Clément Faye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation

(2009) Olga Ostrovsky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species

(2009) M. J. van den Hoven et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypoxia activates heparanase expression in an NF-κB dependent manner

(2009) Wu   ONCOLOGY REPORTS

Heparanase Regulates Levels of Syndecan-1 in the Nucleus

(2009) Ligong Chen et al.   PLoS One

Heparanase is overexpressed in lung cancer and correlates inversely with patient survival

(2008) Esti Cohen et al.   CANCER

Heparanase Augments Epidermal Growth Factor Receptor Phosphorylation: Correlation with Head and Neck Tumor Progression

(2008) V. Cohen-Kaplan et al.   CANCER RESEARCH

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment

(2008) Ghada Abboud-Jarrous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

(2008) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking

(2007) A.L. Rops et al.   KIDNEY INTERNATIONAL