The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders

Dual oxidase: a novel therapeutic target in allergic disease

(2018) Albert van der Vliet et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Amyloid blood biomarker detects Alzheimer's disease

(2018) Andreas Nabers et al.   EMBO Molecular Medicine

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

NADPH Oxidases and Mitochondria in Vascular Senescence

(2018) Gloria Salazar   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Changes of KEAP1/NRF2 and IKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types

(2018) Svetlana V. Kostyuk et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events

(2018) Cristina Carvalho et al.   Frontiers in Physiology

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Degenerative or Debilitative Neurologic Syndromes

(2018) Abby Luck Parish   NURSING CLINICS OF NORTH AMERICA

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

Mitochondria, Oxidative Stress and Innate Immunity

(2018) Yuxin Chen et al.   Frontiers in Physiology

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

(2017) Cátia F. Lourenço et al.   EXPERIMENTAL NEUROLOGY

Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes

(2017) Xinyi Ding et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD

(2017) Dong-Hee Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cerebral amyloid angiopathy, cerebral microbleeds and implications for anticoagulation decisions: The need for a balanced approach

(2017) Andreas Charidimou et al.   International Journal of Stroke

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

Crystal structures and atomic model of NADPH oxidase

(2017) Francesca Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

(2017) Radhika Rastogi et al.   Frontiers in Cellular Neuroscience

Therapeutic potential of NADPH oxidase 1/4 inhibitors

(2016) G Teixeira et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Parkinson Disease and Dementia

(2016) Sara Garcia-Ptacek et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Update on Vascular Dementia

(2016) Ayesha Khan et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage

(2016) S. Piras et al.   Oxidative Medicine and Cellular Longevity

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

NADPH oxidases and vascular remodeling in cardiovascular diseases

(2016) Ana B. García-Redondo et al.   PHARMACOLOGICAL RESEARCH

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

(2016) Fan Su et al.   Neuroscience Bulletin

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors

(2015) M. Cifuentes-Pagano et al.   CURRENT PHARMACEUTICAL DESIGN

Phenolic Metabolites of Anthocyanins Modulate Mechanisms of Endothelial Function

(2015) Michael Edwards et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lipid peroxidation is essential for α-synuclein-induced cell death

(2015) Plamena R. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Zerebrale Amyloidangiopathie und Demenz

(2015) P. Berlit et al.   NERVENARZT

A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937

(2015) Humberto Riera et al.   PLoS One

A modern concept of mixed dementia

(2015) A. N. Bogolepova   Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

(2015) Ilaria Canobbio et al.   Frontiers in Cellular Neuroscience

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia

(2015) Guang-Xia Shi et al.   Scientific Reports

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2

(2014) Sarah Cahill-Smith et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases

(2014) Qingshan Wang et al.   GLIA

What is frontotemporal dementia?

(2014) Alexander Kurz et al.   MATURITAS

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death through Nox1-Regenerated Oxidative Stress

(2014) Dong-Hee Choi et al.   PLoS One

Dementia with Lewy Bodies

(2014) Mary Mayo et al.   SEMINARS IN NEUROLOGY

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

NADPH Oxidase 1, a Novel Molecular Source of ROS in Hippocampal Neuronal Death in Vascular Dementia

(2013) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel link between p53 and ROS

(2013) Zhaoyue He et al.   CELL CYCLE

Circulating Endothelin-1 Alters Critical Mechanisms Regulating Cerebral Microcirculation

(2013) Giuseppe Faraco et al.   HYPERTENSION

Oxidative Stress and Neurodegenerative Disorders

(2013) Jie Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration

(2013) Daniel J. Ranayhossaini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS and Brain Diseases: The Good, the Bad, and the Ugly

(2013) Aurel Popa-Wagner et al.   Oxidative Medicine and Cellular Longevity

Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells

(2013) Aarthi Narayanan et al.   VIROLOGY

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner

(2012) D Vara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glia as a Turning Point in the Therapeutic Strategy of Parkinsons Disease

(2012) Francesca L'Episcopo et al.   CNS & Neurological Disorders-Drug Targets

NADPH Oxidase and Neurodegeneration

(2012) Marina S. Hernandes et al.   Current Neuropharmacology

Reactive Oxygen Species Signaling Facilitates FOXO-3a/FBXO-Dependent Vascular BK Channel  1 Subunit Degradation in Diabetic Mice

(2012) T. Lu et al.   DIABETES

Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)

(2012) Qi-An Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of interferon-γ-induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways

(2012) Rodrigo Herrera-Molina et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive impairment and dementia in Parkinson's disease

(2012) Javier Pagonabarraga et al.   NEUROBIOLOGY OF DISEASE

Cognitive Impairment in Parkinson’s Disease: The Dual Syndrome Hypothesis

(2012) Angie A. Kehagia et al.   Neurodegenerative Diseases

Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS

(2012) Derek A. Drechsel et al.   NEUROTOXICITY RESEARCH

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The TGFbeta Superfamily Signaling Pathway

(2012) Alexander Weiss et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2

(2011) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion

(2011) Yi-Fei Dong et al.   HYPERTENSION

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability

(2011) Christoph W. Blau et al.   NEUROBIOLOGY OF AGING

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

(2011) Annadora J. Bruce-Keller et al.   NEUROBIOLOGY OF DISEASE

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death

(2010) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Angiotensin II–Induced Inflammation and Hypertension

(2010) Talin Ebrahimian et al.   HYPERTENSION

Brain Endothelial Cell Death: Modes, Signaling Pathways, and Relevance to Neural Development, Homeostasis, and Disease

(2010) Maria Teresa Rizzo et al.   MOLECULAR NEUROBIOLOGY

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Role of Rac1 GTPase in NADPH Oxidase Activation and Cognitive Impairment Following Cerebral Ischemia in the Rat

(2010) Limor Raz et al.   PLoS One

Movement disorders after stroke

(2009) A. Handley et al.   AGE AND AGEING

Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-α in cerebral vascular endothelial cells

(2009) Shyamali Basuroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

(2009) Hiroshi Nakanishi et al.   BEHAVIOURAL BRAIN RESEARCH

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

(2009) Carin Thomas et al.   REDOX REPORT

Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice

(2008) Y. Hayashi et al.   JOURNAL OF NEUROSCIENCE

Cognitive Consequences of Multiple Lacunes and Leukoaraiosis as Vascular Cognitive Impairment in Community-Dwelling Elderly Individuals

(2008) Hiroshi Koga et al.   Journal of Stroke & Cerebrovascular Diseases

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA