Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma

(2016) Federica Felicetti et al.   Journal of Translational Medicine

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells

(2014) Yuhui Jiang et al.   Nature Communications

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

(2013) Keith O’Brien et al.   EUROPEAN JOURNAL OF CANCER

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphine Prevents Lipopolysaccharide-Induced TNF Secretion in Mast Cells Blocking I B Kinase Activation and SNAP-23 Phosphorylation: Correlation with the Formation of a  -Arrestin/TRAF6 Complex

(2013) I. K. Madera-Salcedo et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor alpha increases aerobic glycolysis and reduces oxidative metabolism in prostate epithelial cells

(2013) Roger A. Vaughan et al.   PROSTATE

Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology

(2013) Zaheed Husain et al.   OncoImmunology

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Tumor-cell-derived microvesicles as carriers of molecular information in cancer

(2012) Vilma R. Martins et al.   CURRENT OPINION IN ONCOLOGY

ERK1/2 Regulate Exocytosis through Direct Phosphorylation of the Exocyst Component Exo70

(2012) Jinqi Ren et al.   DEVELOPMENTAL CELL

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

(2010) Sonja I Buschow et al.   IMMUNOLOGY AND CELL BIOLOGY

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

How the Golgi works: A cisternal progenitor model

(2010) S. R. Pfeffer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell–derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo

(2009) Grace M. Thomas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

(2008) Kotaro Suzuki et al.   CELL

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE