Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Authors
Keywords
-
Journal
Cancer Medicine
Volume 7, Issue 12, Pages 6124-6136
Publisher
Wiley
Online
2018-11-07
DOI
10.1002/cam4.1820
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA
- (2018) Shengni Hua et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis
- (2018) Carmen Dorneburg et al. CLINICAL CANCER RESEARCH
- LDHA is a direct target of miR-30d-5p and contributes to aggressive progression of gallbladder carcinoma
- (2018) Yuting He et al. MOLECULAR CARCINOGENESIS
- Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer
- (2018) Jie Ma et al. Journal of Immunology Research
- Increased Lactate in Gastric Cancer Tumor-Infiltrating Lymphocytes Is Related to Impaired T Cell Function Due to miR-34a Deregulated Lactate Dehydrogenase A
- (2018) Wang Ping et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA
- (2018) Hanwen Chen et al. Human Cell
- Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
- (2017) L Jin et al. ONCOGENE
- MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation
- (2017) Liang Li et al. ONCOLOGY RESEARCH
- Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation
- (2017) Yapeng Ji et al. Nature Communications
- Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
- (2017) Tieying Dong et al. Scientific Reports
- LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer
- (2016) Fujin Jiang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
- (2016) Almut Brand et al. Cell Metabolism
- Sensitization of hepatocellular carcinoma cells to irradiation by miR-34a through targeting lactate dehydrogenase-A
- (2016) XIAOGANG LI et al. Molecular Medicine Reports
- The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer
- (2016) Xiangsheng Xiao et al. Scientific Reports
- The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor
- (2015) Cara J. Valvona et al. BRAIN PATHOLOGY
- Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer
- (2015) Katarzyna Augoff et al. CANCER LETTERS
- Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway
- (2015) Zhi Zhao et al. CANCER LETTERS
- Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy
- (2015) Reshma Rani et al. JOURNAL OF MEDICINAL CHEMISTRY
- The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer
- (2015) Tian-Lin He et al. MEDICAL ONCOLOGY
- Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer
- (2015) Jian Wang et al. Oncotarget
- Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
- (2015) Robert Haas et al. PLOS BIOLOGY
- Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms
- (2015) Subramaniapillai Kolappan et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Increased Serum Lactate Dehydrongenase Should Be Included Among the Variables That Define Very-High-Risk Multiple Myeloma
- (2015) Maria Gkotzamanidou et al. Clinical Lymphoma Myeloma & Leukemia
- Acetylation control of metabolic enzymes in cancer: an updated version
- (2014) W. Huang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
- (2014) Han Xie et al. Cell Metabolism
- FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression
- (2014) J. Cui et al. CLINICAL CANCER RESEARCH
- A Novel KLF4/LDHA Signaling Pathway Regulates Aerobic Glycolysis in and Progression of Pancreatic Cancer
- (2014) M. Shi et al. CLINICAL CANCER RESEARCH
- Inhibition of lactate dehydrogenase activity as an approach to cancer therapy
- (2014) Luigi Fiume et al. Future Medicinal Chemistry
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
- (2014) H. Shime et al. JOURNAL OF IMMUNOLOGY
- P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy
- (2014) Ding-Guo Zhang et al. Molecular Cancer
- Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil
- (2014) XIANGYONG LI et al. Molecular Medicine Reports
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Synergistic Anti-Cancer Effect of Phenformin and Oxamate
- (2014) W. Keith Miskimins et al. PLoS One
- Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways
- (2014) S J Allison et al. Oncogenesis
- Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
- (2013) M Maftouh et al. BRITISH JOURNAL OF CANCER
- Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
- (2013) Di Zhao et al. CANCER CELL
- Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration
- (2013) Robert Arseneault et al. CANCER LETTERS
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
- (2013) Chih-Hao Chang et al. CELL
- Small-molecule inhibitors of human LDH5
- (2013) Carlotta Granchi et al. Future Medicinal Chemistry
- Association between hemoglobin, calcium, and lactate dehydrogenase variability and mortality among metastatic renal cell carcinoma
- (2013) Bulent Cetin et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy
- (2013) Ping Miao et al. IUBMB LIFE
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors
- (2013) Anna Kohlmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lactate dehydrogenase A silencing in IDH mutant gliomas
- (2013) Charles Chesnelong et al. NEURO-ONCOLOGY
- Lactate Dehydrogenase 5 Expression in Non-Hodgkin Lymphoma Is Associated with the Induced Hypoxia Regulated Protein and Poor Prognosis
- (2013) Renquan Lu et al. PLoS One
- Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
- (2013) Yefei Rong et al. TUMOR BIOLOGY
- Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
- (2012) Paolo E. Porporato et al. ANGIOGENESIS
- Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
- (2012) Luigi Fiume et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4
- (2012) Yongjie Zhang et al. CANCER LETTERS
- Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy
- (2012) Y. Jin et al. EUROPEAN JOURNAL OF CANCER
- Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
- (2012) F. Farabegoli et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma
- (2012) Shi L. Sheng et al. FEBS Journal
- Na+/H+ Exchanger 1 Directly Binds to Calcineurin A and Activates Downstream NFAT Signaling, Leading to Cardiomyocyte Hypertrophy
- (2012) T. Hisamitsu et al. MOLECULAR AND CELLULAR BIOLOGY
- LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma
- (2012) Feng Yao et al. TUMOR BIOLOGY
- LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis
- (2011) Zhi-Yu Wang et al. BREAST CANCER RESEARCH AND TREATMENT
- Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis
- (2011) F. Vegran et al. CANCER RESEARCH
- Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
- (2011) Marcella Manerba et al. ChemMedChem
- Prognostic and Predictive Role of Lactate Dehydrogenase 5 Expression in Colorectal Cancer Patients Treated with PTK787/ZK 222584 (Vatalanib) Antiangiogenic Therapy
- (2011) M. I. Koukourakis et al. CLINICAL CANCER RESEARCH
- Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells
- (2011) Carlotta Granchi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genome-wide Characterization ofmiR-34aInduced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis
- (2011) Markus Kaller et al. MOLECULAR & CELLULAR PROTEOMICS
- miR-29a and miR-29b Contribute to Pancreatic -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)
- (2011) T. J. Pullen et al. MOLECULAR AND CELLULAR BIOLOGY
- Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells
- (2011) J. Fan et al. MOLECULAR AND CELLULAR BIOLOGY
- LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo
- (2011) Stefan Langhammer et al. Targeted Oncology
- Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
- (2010) Gian Kayser et al. Diagnostic Pathology
- The engine driving the ship: metabolic steering of cell proliferation and death
- (2010) Marisa R. Buchakjian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence
- (2010) D. R. Littler et al. NUCLEIC ACIDS RESEARCH
- Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
- (2010) A. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
- (2010) A. J. Levine et al. SCIENCE
- Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
- (2009) Liqing Zhuang et al. MODERN PATHOLOGY
- LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
- (2009) H. Xie et al. MOLECULAR CANCER THERAPEUTICS
- Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
- (2009) Y H Zhao et al. ONCOGENE
- Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis
- (2008) Yanislav Kolev et al. ANNALS OF SURGICAL ONCOLOGY
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
- (2008) Paola Allavena et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2
- (2008) Fusun Baumann et al. NEURO-ONCOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started