LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

(2017) L Jin et al.   ONCOGENE

Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade

(2017) Inna Serganova et al.   Molecular Therapy-Oncolytics

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

(2016) Fujin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Metabolic regulation of immune responses: therapeutic opportunities

(2016) Nadine Assmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Gain of HIF-1  under Normoxia in Cancer Mediates Immune Adaptation through the AKT/ERK and VEGFA Axes

(2015) Y.-H. Lee et al.   CLINICAL CANCER RESEARCH

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Inhibition of LDHA suppresses tumor progression in prostate cancer

(2015) Zhi-Yong Xian et al.   TUMOR BIOLOGY

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

On-target Inhibition of Tumor Fermentative Glycolysis as Visualized by Hyperpolarized Pyruvate

(2015) Pankaj Seth et al.   NEOPLASIA

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

HIF-2α as a prognostic marker for breast cancer progression and patient survival

(2014) H.X. Wang et al.   GENETICS AND MOLECULAR RESEARCH

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Relationships between LDH-A, Lactate, and Metastases in 4T1 Breast Tumors

(2013) A. Rizwan et al.   CLINICAL CANCER RESEARCH

Hypoxia inducible factor-1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study

(2013) Yoichiro Matsuo et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4

(2012) Yongjie Zhang et al.   CANCER LETTERS

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

(2011) Zhi-Yu Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer

(2011) C. H. Richards et al.   BRITISH JOURNAL OF SURGERY

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype

(2011) I. Serganova et al.   CLINICAL CANCER RESEARCH

The prognostic value of histological tumor necrosis in solid organ malignant disease: a systematic review

(2011) Colin H Richards et al.   Future Oncology

Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients

(2010) Esther M. de Kruijf et al.   BREAST CANCER RESEARCH AND TREATMENT

Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model

(2010) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Targeting of Carbonic Anhydrase IX in Mice with Hypoxic HT29 Colorectal Tumor Xenografts

(2010) Sean Carlin et al.   PLoS One

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimodality imaging of TGFβ signaling in breast cancer metastases

(2009) Inna Serganova et al.   FASEB JOURNAL

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

(2009) H. Xie et al.   MOLECULAR CANCER THERAPEUTICS

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase

(2009) Elmer B Santos et al.   NATURE MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Monitoring the Efficacy of Adoptively Transferred Prostate Cancer-Targeted Human T Lymphocytes with PET and Bioluminescence Imaging

(2008) K. Dobrenkov et al.   JOURNAL OF NUCLEAR MEDICINE

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE