The 1,2,3-triazole ‘all-in-one’ ring system in drug discovery: a good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool

Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors

(2022) Gehan A. Abdel-Hafez et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Antimicrobial and in-silico evaluation of novel chalcone and amide-linked 1,4-disubstituted 1,2,3 triazoles

(2022) Manish Kumar Sharma et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and Antitumor Activity of Erlotinib Derivatives Linked With 1,2,3-Triazole

(2022) Peng Deng et al.   Frontiers in Pharmacology

Discovery of a Series of 1,2,3-Triazole-Containing Erlotinib Derivatives With Potent Anti-Tumor Activities Against Non-Small Cell Lung Cancer

(2022) Ge Sun et al.   Frontiers in Chemistry

Ciprofloxacin-Tethered 1,2,3-Triazole Conjugates: New Quinolone Family Compounds to Upgrade Our Antiquated Approach against Bacterial Infections

(2022) Alka Agarwal et al.   ACS Omega

Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking

(2022) Maged A. El Sawy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A review on synthesis, mechanism of action, and structure-activity relationships of 1,2,3-triazole-based α-glucosidase inhibitors as promising anti-diabetic agents

(2022) Zari Fallah et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1,2,3-Triazole derivatives as potent inhibitors of carbonic anhydrase, acetylcholinesterase and aldose reductase

(2022) Derya Aktas Anil et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

(2022) Suresh Dharuman et al.   MOLECULES

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2

(2022) Wael A. El-Sayed et al.   MOLECULES

Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications

(2022) Mohammed M. Matin et al.   Frontiers in Molecular Biosciences

Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action

(2022) Yahya Nural et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors

(2022) Xiaoyan Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice

(2021) Yan Zheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach

(2021) Mengyang Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

(2021) Mohammad Mahboob Alam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of 4-anilinoquinazolines as Raf kinase inhibitors. Part 1. Selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 inhibitory 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines

(2021) Cheng-I Lee et al.   BIOORGANIC CHEMISTRY

Alzheimer’s disease and its treatment by different approaches: A review

(2021) Sukriti Srivastava et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease

(2021) Annelies Stevaert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors

(2021) Yang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents

(2021) Sampath Bitla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia

(2021) Ziying Feng et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity

(2021) Paulo Sérgio Gonçalves Nunes et al.   BIOORGANIC CHEMISTRY

New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2

(2021) Israa A. Seliem et al.   BIOORGANIC CHEMISTRY

Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications

(2021) Anand K. Agrahari et al.   CHEMICAL REVIEWS

Flavonoid-triazolyl hybrids as potential anti-hepatitis C virus agents: Synthesis and biological evaluation

(2021) Han Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

(2021) Andrew K. Dilger et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity

(2021) Huarui Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa

(2021) Dirk Thomas et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Design, synthesis, and biological evaluation of some 1,2,3-triazole derivatives as novel amide-based inhibitors of soluble epoxide hydrolase

(2021) Elham Rezaee et al.   MEDICINAL CHEMISTRY RESEARCH

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

(2021) Ting Liang et al.   Frontiers in Pharmacology

Synthesis of New 1H-1,2,3-Triazole Analogs in Aqueous Medium via “Click” Chemistry: A Novel Class of Potential Carbonic Anhydrase-II Inhibitors

(2021) Satya Kumar Avula et al.   Frontiers in Chemistry

1,2,3‐Triazole hybrids as anticancer agents: A review

(2021) Mohammad Mahboob Alam   ARCHIV DER PHARMAZIE

Design, synthesis, and biological evaluation of novel Bcr-AblT315I inhibitors incorporating amino acids as flexible linker

(2021) Xiaoyan Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and antibacterial evaluation of novel 3-O-substituted 15-membered azalides possessing 1,2,3-triazole side chains

(2021) Yinhui Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants

(2021) Yahya Nural et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click ferrocenyl-erlotinib conjugates active against erlotinib-resistant non-small cell lung cancer cells in vitro

(2021) Przemysław Biegański et al.   BIOORGANIC CHEMISTRY

Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity

(2021) Harmandeep Kaur Gulati et al.   BIOORGANIC CHEMISTRY

Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids

(2021) Josyelen L. Felipe et al.   BIOORGANIC CHEMISTRY

Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

(2021) Ludivine Taiariol et al.   CHEMICAL REVIEWS

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents

(2021) Dongguang Fan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of 1,4-disubstituted 1,2,3-triazoles: Biological evaluation, in silico molecular docking and ADME screening

(2021) İrfan Şahin et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of triaromatic flexible agents bearing 1,2,3-Triazole with selective and potent anti-breast cancer activity and CDK9 inhibition supported by molecular dynamics

(2021) Saleh K. Ihmaid et al.   JOURNAL OF MOLECULAR STRUCTURE

Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies

(2021) Nisha Poonia et al.   MOLECULAR DIVERSITY

Discovery of a Series of Theophylline Derivatives Containing 1,2,3-Triazole for Treatment of Non-Small Cell Lung Cancer

(2021) Jiahui Ye et al.   Frontiers in Pharmacology

1,2,3-Triazoles of 8-Hydroxyquinoline and HBT: Synthesis and Studies (DNA Binding, Antimicrobial, Molecular Docking, ADME, and DFT)

(2021) Nidhi Nehra et al.   ACS Omega

1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226

(2020) Heba F. Ashour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

(2020) Lin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770

(2020) Jake E. Doiron et al.   ChemMedChem

In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP

(2020) Dongwei Kang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species

(2020) Wu Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids

(2020) Chris-Marie Horn et al.   MEDICINAL CHEMISTRY RESEARCH

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

(2020) Perihan A. Elzahhar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (Ido1) and trytophan 2,3-dioxygenase (TDO)

(2020) Shulei Pan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

(2020) Annalaura Brai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

(2020) Zeping Zuo et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2,3‐Triazole hybrids with anti‐HIV‐1 activity

(2020) Lian‐Shun Feng et al.   ARCHIV DER PHARMAZIE

Recent Advances in 1,2,4‐Triazole Scaffolds as Antiviral Agents

(2020) S. A. El‐Sebaey   ChemistrySelect

A novel synthetic acanthoic acid analogues and their cytotoxic activity in cholangiocarcinoma cells

(2020) Teerapich Kasemsuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone–triazole hybrids

(2020) Yahya Nural et al.   BIOORGANIC CHEMISTRY

Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents

(2020) Divya Dheer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions

(2020) Guang Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

(2020) Cheng-Peng Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies

(2020) Ramesh Gondru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1,2,3-triazoles

(2020) Sumit Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection

(2019) Annalaura Brai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis and Evaluation of Novel Heteroaryldihydropyrimidines Derivatives as Non-nucleoside Hepatitis B Virus Inhibitors by Exploring the Solvent-exposed Region

(2019) Ji Yu et al.   Chemical Biology & Drug Design

Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors

(2019) Vikas Sharma et al.   BIOORGANIC CHEMISTRY

Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids

(2019) Bo Zhang   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydroquinolines as dual inhibitors of Mycobacterium tuberculosis and influenza virus: Synthesis and evaluation

(2019) Sandeep Kumar Marvadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

(2019) Viktoriya Ivasiv et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, Synthesis and Antibacterial Activity of Coumarin-1,2,3-triazole Hybrids Obtained from Natural Furocoumarin Peucedanin

(2019) Alla V. Lipeeva et al.   MOLECULES

Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors

(2019) Angela S. Carlson et al.   ACS Medicinal Chemistry Letters

Synthesis of novel (R)-4-fluorophenyl-1H-1,2,3-triazoles: A new class of α-glucosidase inhibitors

(2019) Satya Kumar Avula et al.   BIOORGANIC CHEMISTRY

Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids

(2019) Feng Gao et al.   BIOORGANIC CHEMISTRY

Promising antibacterial agents against multidrug resistant Staphylococcus aureus

(2019) Srikanth Gatadi et al.   BIOORGANIC CHEMISTRY

Design, synthesis of oleanolic acid-saccharide conjugates using click chemistry methodology and study of their anti-influenza activity

(2019) Yangqing Su et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytokines in Inflammatory Disease

(2019) Shinwan Kany et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heterocycles in Medicinal Chemistry

(2019) Josef Jampilek   MOLECULES

A novel series of 11-O-carbamoyl-3-O-descladinosyl clarithromycin derivatives bearing 1,2,3-triazole group: Design, synthesis and antibacterial evaluation

(2019) Yuetai Teng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click chemistry synthesis, biological evaluation and docking study of some novel 2′-hydroxychalcone-triazole hybrids as potent anti-inflammatory agents

(2019) Andrew N. Boshra et al.   BIOORGANIC CHEMISTRY

Bioisosteric Replacement of Amide Group with 1,2,3-Triazoles in Acetaminophen Addresses Reactive Oxygen Species-Mediated Hepatotoxic Insult in Wistar Albino Rats

(2019) Adarsh Sahu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity

(2019) Han Ju et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives

(2019) Andrijana Meščić Macan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

(2019) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

(2019) Jun-Jie Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advancements in 1,4-Disubstituted 1H-1,2,3-Triazoles as Potential Anticancer Agents

(2018) Kashmiri Lal et al.   Anti-Cancer Agents in Medicinal Chemistry

DEAD-box helicases: the Yin and Yang roles in viral infections

(2018) Vanessa Meier-Stephenson et al.   Biotechnology & Genetic Engineering Reviews

Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors

(2018) Rajiv Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

(2018) Hanane Kaoukabi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives

(2018) Ai-Ling Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Recent developments on triazole nucleus in anticonvulsant compounds: a review

(2018) Ming-Xia Song et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of 1H-1,2,3-triazole derivatives as new α-glucosidase inhibitors and their molecular docking studies

(2018) Satya Kumar Avula et al.   BIOORGANIC CHEMISTRY

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

(2018) Gaochan Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus

(2018) Srikanth Gatadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triazole derivatives and their anti-tubercular activity

(2017) Shu Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

(2017) Stephen Brand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

(2017) Phillip P. Sharp et al.   ACS Medicinal Chemistry Letters

Regioselective synthesis of multisubstituted 1,2,3-triazoles: moving beyond the copper-catalyzed azide–alkyne cycloaddition

(2016) Fang Wei et al.   CHEMICAL COMMUNICATIONS

A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones

(2016) Joice Thomas et al.   CHEMICAL COMMUNICATIONS

Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids

(2016) Tatjana Gazivoda Kraljević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The importance of triazole scaffold in the development of anticonvulsant agents

(2016) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists

(2016) Idrees Mohammed et al.   JOURNAL OF MEDICINAL CHEMISTRY

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

(2016) Muhammad Malik et al.   NUCLEIC ACIDS RESEARCH

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

(2016) Annalaura Brai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triazole: A Promising Antitubercular Agent

(2015) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Organocatalytic routes toward substituted 1,2,3-triazoles

(2015) Jubi John et al.   CHEMICAL COMMUNICATIONS

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

(2015) Roberta Fazi et al.   Journal of Chemical Information and Modeling

Are 1,4- and 1,5-Disubstituted 1,2,3-Triazoles Good Pharmacophoric Groups?

(2014) Alberto Massarotti et al.   ChemMedChem

1,2,3-Triazole in Heterocyclic Compounds, Endowed with Biological Activity, through 1,3-Dipolar Cycloadditions

(2014) Antonino Lauria et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses

(2014) Maorong Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide

(2014) H. Yan et al.   JOURNAL OF VIROLOGY

Roles of HIV-1 capsid in viral replication and immune evasion

(2014) Valerie Le Sage et al.   VIRUS RESEARCH

Suvorexant for the treatment of insomnia

(2014) Laura H Jacobson et al.   Expert Review of Clinical Pharmacology

Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways

(2013) Karin Meirer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Emerging Antiviral Strategies to Interfere with Influenza Virus Entry

(2013) Evelien Vanderlinden et al.   MEDICINAL RESEARCH REVIEWS

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication

(2012) Akbar Ali et al.   ChemMedChem

The impact of click chemistry in medicinal chemistry

(2012) Jingli Hou et al.   Expert Opinion on Drug Discovery

Mitigating Heterocycle Metabolism in Drug Discovery

(2012) David J. St. Jean et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale

(2011) T. A. Wallace et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication

(2011) A. Garbelli et al.   CURRENT MEDICINAL CHEMISTRY

Click-Triazole N2 Coordination to Transition-Metal Ions Is Assisted by a Pendant Pyridine Substituent

(2010) Damijana Urankar et al.   INORGANIC CHEMISTRY

Pharmacological significance of triazole scaffold

(2010) Rajeev Kharb et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances and Future Perspectives of Triazole Analogs as Promising Antiviral Agents

(2010) Rajeev Kharb et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics

(2008) Jiacheng Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS