Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents

Chemical Classes Presenting Novel Antituberculosis Agents Currently in Different Phases of Drug Development: A 2010–2020 Review

(2021) Klaudia T. Angula et al.   Pharmaceuticals

Development of Macozinone for TB treatment: An Update

(2020) Vadim Makarov et al.   Applied Sciences-Basel

Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents

(2020) Lingfeng Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties

(2019) Gang Zhang et al.   ACS Medicinal Chemistry Letters

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase

(2019) Galina Karabanovich et al.   JOURNAL OF MEDICINAL CHEMISTRY

hERG optimizations of IMB1603, discovery of alternative benzothiazinones as new antitubercular agents

(2019) Kai Lv et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis

(2018) Jérémie Piton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells

(2018) Suping Chen et al.   FEBS Journal

Click Chemistry-Based Discovery of [3-Hydroxy-5-(1H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia

(2018) Yue Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Better Pharmacokinetic Benzothiazinone Derivatives as New Antitubercular Agents

(2017) Kai Lv et al.   ACS Medicinal Chemistry Letters

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

(2014) João Neres et al.   ACS Chemical Biology

Towards a new combination therapy for tuberculosis with next generation benzothiazinones

(2014) V. Makarov et al.   EMBO Molecular Medicine

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

Mitigating Heterocycle Metabolism in Drug Discovery

(2012) David J. St. Jean et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

(2011) Claudia Trefzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE