Emerging Antiviral Strategies to Interfere with Influenza Virus Entry

Sialylneolacto-N-tetraose c (LSTc)-bearing Liposomal Decoys Capture Influenza A Virus

(2013) Gabriel L. Hendricks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro

(2013) T. Baranovich et al.   JOURNAL OF VIROLOGY

Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity

(2013) J.-H. Kim et al.   SCIENCE

Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket

(2013) Fei Yu et al.   Viruses-Basel

Human Monoclonal Antibodies Broadly Neutralizing against Influenza B Virus

(2013) Mayo Yasugi et al.   PLoS Pathogens

Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors

(2012) Xin Zhao et al.   ANTIVIRAL RESEARCH

Targeting the host or the virus: Current and novel concepts for antiviral approaches against influenza virus infection

(2012) Suki Man-Yan Lee et al.   ANTIVIRAL RESEARCH

A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D

(2012) Martin van Eijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetic Properties ofAnti-Influenza Neuraminidase Inhibitors

(2012) Kalayanee Chairat et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Expanding the Armamentarium Against Respiratory Viral Infections: DAS181

(2012) M. G. Ison   JOURNAL OF INFECTIOUS DISEASES

Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein

(2012) Huimin Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Changes in Influenza Virus at Low pH Characterized by Cryo-Electron Tomography

(2012) J. Fontana et al.   JOURNAL OF VIROLOGY

Intracytoplasmic Trapping of Influenza Virus by a Lipophilic Derivative of Aglycoristocetin

(2012) E. Vanderlinden et al.   JOURNAL OF VIROLOGY

Evidence for N-Glycan Shielding of Antigenic Sites during Evolution of Human Influenza A Virus Hemagglutinin

(2012) Y. Kobayashi et al.   JOURNAL OF VIROLOGY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Effect of a Single Inhalation of Laninamivir Octanoate in Children With Influenza

(2012) Y. Katsumi et al.   PEDIATRICS

Dissection of Influenza A Virus M1 Protein: pH-Dependent Oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain

(2012) Ke Zhang et al.   PLoS One

Influenza virus binds its host cell using multiple dynamic interactions

(2012) C. Sieben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

(2012) A. G. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H5N1 influenza viruses: Facts, not fear

(2012) P. Palese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site

(2012) X. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity

(2012) P. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

A review of influenza haemagglutinin receptor binding as it relates to pandemic properties

(2012) Sam Wilks et al.   VACCINE

Nuclear import of the influenza A virus transcriptional machinery

(2012) E.C. Hutchinson et al.   VACCINE

Influenza Virus-Mediated Membrane Fusion: Determinants of Hemagglutinin Fusogenic Activity and Experimental Approaches for Assessing Virus Fusion

(2012) Brian S. Hamilton et al.   Viruses-Basel

The role of receptor binding specificity in interspecies transmission of influenza viruses

(2012) Masaki Imai et al.   Current Opinion in Virology

An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity

(2012) Annapurna Nayak et al.   Frontiers in Immunology

Structural basis of influenza virus neutralization

(2011) Thomas Han et al.   Annals of the New York Academy of Sciences

Zanamivir Pharmacokinetics and Pulmonary Penetration into Epithelial Lining Fluid following Intravenous or Oral Inhaled Administration to Healthy Adult Subjects

(2011) Mark J. Shelton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza

(2011) Nicasio Mancini et al.   ANTIVIRAL RESEARCH

Nanobodies®: New ammunition to battle viruses

(2011) Peter Vanlandschoot et al.   ANTIVIRAL RESEARCH

In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03

(2011) Meehyein Kim et al.   ANTIVIRAL RESEARCH

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities

(2011) Eva Torres et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Systematic review of influenza resistance to the neuraminidase inhibitors

(2011) Kristian Thorlund et al.   BMC INFECTIOUS DISEASES

Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

(2011) Eike R. Hrincius et al.   CELLULAR MICROBIOLOGY

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus

(2011) Jun Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A review of palivizumab and emerging therapies for respiratory syncytial virus

(2011) Kristin A Shadman et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mutagenesis of Surfactant Protein D Informed by Evolution and X-ray Crystallography Enhances Defenses against Influenza A Virusin Vivo

(2011) Erika Crouch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Introduction ofN-Linked Glycans in the Lectin Domain of Surfactant Protein D

(2011) Martin van Eijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice

(2011) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Nanobodies With In Vitro Neutralizing Activity Protect Mice Against H5N1 Influenza Virus Infection

(2011) Lorena Itatí Ibañez et al.   JOURNAL OF INFECTIOUS DISEASES

Evaluation of the Antiviral Response to Zanamivir Administered Intravenously for Treatment of Critically Ill Patients With Pandemic Influenza A (H1N1) Infection

(2011) P. L. A. Fraaij et al.   JOURNAL OF INFECTIOUS DISEASES

Exploring the Size Limit of Templates for Inhibitors of the M2 Ion Channel of Influenza A Virus

(2011) María D. Duque et al.   JOURNAL OF MEDICINAL CHEMISTRY

NMR Detection of pH-Dependent Histidine–Water Proton Exchange Reveals the Conduction Mechanism of a Transmembrane Proton Channel

(2011) Fanghao Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

(2011) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Characterization of the Hemagglutinin Receptor Specificity from the 2009 H1N1 Influenza Pandemic

(2011) R. Xu et al.   JOURNAL OF VIROLOGY

Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial

(2011) Nicholas I Paton et al.   LANCET INFECTIOUS DISEASES

Towards universal influenza vaccines?

(2011) A. Osterhaus et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol

(2011) Elodie Teissier et al.   PLoS One

Inhibition of Influenza A Virus (H1N1) Fusion by Benzenesulfonamide Derivatives Targeting Viral Hemagglutinin

(2011) Lei Zhu et al.   PLoS One

A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes

(2011) Nicola Clementi et al.   PLoS One

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

(2011) S. W. Gerritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The host interactome of influenza virus presents new potential targets for antiviral drugs

(2011) Megan L. Shaw   REVIEWS IN MEDICAL VIROLOGY

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

(2011) D. C. Ekiert et al.   SCIENCE

Influenza virus assembly and budding

(2011) Jeremy S. Rossman et al.   VIROLOGY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

(2011) Christopher J. Vavricka et al.   PLoS Pathogens

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

(2011) Eric M. Feeley et al.   PLoS Pathogens

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

(2011) Erik de Vries et al.   PLoS Pathogens

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro

(2010) Larisa V Gubareva et al.   ANTIVIRAL THERAPY

Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus

(2010) Ekta Khurana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Cellular Networks Involved in the Influenza Virus Life Cycle

(2010) Tokiko Watanabe et al.   Cell Host & Microbe

Long‐Acting Neuraminidase Inhibitor Laninamivir Octanoate versus Oseltamivir for Treatment of Influenza: A Double‐Blind, Randomized, Noninferiority Clinical Trial

(2010) Akira Watanabe et al.   CLINICAL INFECTIOUS DISEASES

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

(2010) Grigoris Zoidis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of highly potent agents against influenza A virus

(2010) Xin Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181

(2010) Gallen B. Triana-Baltzer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialidase‐Based Anti–Influenza Virus Therapy Protects against Secondary Pneumococcal Infection

(2010) Maria Hedlund et al.   JOURNAL OF INFECTIOUS DISEASES

A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo

(2010) Anne Moscona et al.   JOURNAL OF INFECTIOUS DISEASES

Sialic Acid-Mimic Peptides As Hemagglutinin Inhibitors for Anti-Influenza Therapy

(2010) Teruhiko Matsubara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

(2010) Sankar Mohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library

(2010) Wenhui Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membranotropic Effects of Arbidol, a Broad Anti-Viral Molecule, on Phospholipid Model Membranes

(2010) José Villalaín   JOURNAL OF PHYSICAL CHEMISTRY B

Novel Inhibitors of Influenza Virus Fusion: Structure-Activity Relationship and Interaction with the Viral Hemagglutinin

(2010) E. Vanderlinden et al.   JOURNAL OF VIROLOGY

Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages

(2010) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Potential of carbohydrate-binding agents as therapeutics against enveloped viruses

(2010) K. O. François et al.   MEDICINAL RESEARCH REVIEWS

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

(2010) Erhard van der Vries et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

(2010) C.-Y. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition and Functions of the Influenza Fusion Peptide

(2010) Karen Cross et al.   PROTEIN AND PEPTIDE LETTERS

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

(2010) Stephanie Bertram et al.   REVIEWS IN MEDICAL VIROLOGY

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

(2010) Thorsten Eierhoff et al.   PLoS Pathogens

Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

(2010) Suman R. Das et al.   PLoS Pathogens

Flu channel drug resistance: a tale of two sites

(2010) Rafal M. Pielak et al.   Protein & Cell

Glycyrrhizin inhibits influenza A virus uptake into the cell

(2009) Andrea Wolkerstorfer et al.   ANTIVIRAL RESEARCH

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Anti-influenza virus activity and structure–activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains

(2009) Lieve Naesens et al.   ANTIVIRAL RESEARCH

Functional Studies and Modeling of Pore-Lining Residue Mutants of the Influenza A Virus M2 Ion Channel

(2009) Victoria Balannik et al.   BIOCHEMISTRY

Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro

(2009) Qing-long Liang et al.   BIOTECHNOLOGY LETTERS

The Influenza Virus Enigma

(2009) Rachelle Salomon et al.   CELL

Pharmacokinetic properties and bioequivalence of two formulations of arbidol: An open-label, single-dose, randomized-sequence, two-period crossover study in healthy chinese male volunteers

(2009) Ming-Yan Liu et al.   CLINICAL THERAPEUTICS

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

(2009) S. Ludwig   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase

(2009) Jianghong An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Influenza Virus Infections by Sialylgalactose-Binding Peptides Selected from a Phage Library

(2009) Teruhiko Matsubara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure, Receptor Binding, and Antigenicity of Influenza Virus Hemagglutinins from the 1957 H2N2 Pandemic

(2009) R. Xu et al.   JOURNAL OF VIROLOGY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Solution structure and functional analysis of the influenza B proton channel

(2009) Junfeng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza

(2009) Debra Birnkrant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Emerging antiviral targets for influenza A virus

(2009) Robert M. Krug et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses

(2009) Reiko Yoshida et al.   PLoS Pathogens

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N

(2008) D SMEE et al.   ANTIVIRAL RESEARCH

Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol

(2008) Irina A. Leneva et al.   ANTIVIRAL RESEARCH

S Acylation of the Hemagglutinin of Influenza Viruses: Mass Spectrometry Reveals Site-Specific Attachment of Stearic Acid to a Transmembrane Cysteine

(2008) L. V. Kordyukova et al.   JOURNAL OF VIROLOGY

Monoclonal Antibodies against the Fusion Peptide of Hemagglutinin Protect Mice from Lethal Influenza A Virus H5N1 Infection

(2008) N. Prabhu et al.   JOURNAL OF VIROLOGY

Crystal Structure of Unliganded Influenza B Virus Hemagglutinin

(2008) Q. Wang et al.   JOURNAL OF VIROLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

(2008) Patrick J. Collins et al.   NATURE

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

(2008) Aarthi Chandrasekaran et al.   NATURE BIOTECHNOLOGY

Fatal Oseltamivir-Resistant Influenza Virus Infection

(2008) Erhard van der Vries et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

(2008) R. J. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolving complexities of influenza virus and its receptors

(2008) John M. Nicholls et al.   TRENDS IN MICROBIOLOGY

Epidemiology of influenza

(2008) Arnold S. Monto   VACCINE

Medical Management of Influenza Infection

(2007) Anne Moscona   Annual Review of Medicine