Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

(2021) Anca-Maria Borcea et al.   MOLECULES

Synthesis, Characterization, and Antioxidant and Anticancer Activity of 1,4-Disubstituted 1,2,3-triazoles

(2021) İrfan Şahin et al.   JOURNAL OF MOLECULAR STRUCTURE

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies

(2021) Celia Martín-Beltrán et al.   Pharmaceuticals

Pyrazoline tethered 1,2,3-triazoles: Synthesis, antimicrobial evaluation and in silico studies

(2021) Lokesh Kumar et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes

(2020) Mohammed T.-E. Maghraby et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent

(2020) Mohammad Rashid   BIOORGANIC CHEMISTRY

Multiple Molecular Targets Mediated Antioxidant Activity, Molecular Docking, ADMET, QSAR and Bioactivity Studies of Halo Substituted Urea Derivatives of α-Methyl-L-DOPA

(2020) Vadabingi Nagalakshmamma et al.   BIOORGANIC CHEMISTRY

Microbial resistance and resilience in response to environmental changes under the higher intensity of human activities than global average level

(2020) Laibin Huang et al.   GLOBAL CHANGE BIOLOGY

PPAR gamma targeted molecular docking and synthesis of some new amide and urea substituted 1, 3, 4‐thiadiazole derivative as antidiabetic compound

(2020) Yogesh Vaishnav et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, synthesis, crystal structure and in vitro antimicrobial activity of novel 1,2,4-triazolo[1,5-a]pyrimidine-containing quinazolinone derivatives

(2020) Huan Du et al.   MOLECULAR DIVERSITY

Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

(2020) Thoraya A. Farghaly et al.   BIOORGANIC CHEMISTRY

Structure-based virtual screening of influenza virus RNA polymerase inhibitors from natural compounds: Molecular dynamics simulation and MM-GBSA calculation

(2020) Zhe Jin et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents

(2020) Omid Zarei et al.   MEDICINAL CHEMISTRY RESEARCH

Design and synthesis of 4,5-diphenyl-imidazol-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic and docking studies

(2020) Mohammad Sadegh Asgari et al.   MOLECULAR DIVERSITY

Design, in silico, one-pot synthesis, and biological evaluations of novel bis-urea analogs

(2020) Sajede Shoja et al.   RESEARCH ON CHEMICAL INTERMEDIATES

5-Fluoro-1H-indole-2,3-dione-triazoles- synthesis, biological activity, molecular docking, and DFT study

(2020) Sonal Deswal et al.   JOURNAL OF MOLECULAR STRUCTURE

Microbial communities modulating brain functioning and behaviors in zebrafish: A mechanistic approach

(2020) Larica Mohanta et al.   MICROBIAL PATHOGENESIS

Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids

(2020) Paul Awolade et al.   MOLECULAR DIVERSITY

Developments in the Application of 1,2,3-Triazoles in Cancer Treatment

(2020) Katerina I. Slavova et al.   Recent Patents on Anti-Cancer Drug Discovery

Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes

(2020) Muhammad Usman Munir et al.   International Journal of Nanomedicine

Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1,2,3-triazole hybrids

(2020) Lokesh Kumar et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, antimicrobial evaluation and docking studies of urea-triazole-amide hybrids

(2020) Kashmiri Lal et al.   JOURNAL OF MOLECULAR STRUCTURE

Ultrasonic-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ol Tethered with 1,2,3-Triazoles and Their Anticancer Activity

(2020) Prakash L. Kalavadiya et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Targeting SARS-CoV-2 main protease: structure based virtual screening, in silico ADMET studies and molecular dynamics simulation for identification of potential inhibitors

(2020) Ankit Uniyal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies

(2020) Ramesh Gondru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

(2019) Khurshed Bozorov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The potential role of interleukin-37 in infectious diseases

(2019) Gamal Allam et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Synthesis and characterization of 1,2,3-triazoles-linked urea hybrid sensor for selective sensing of fluoride ion

(2019) Poonam Rani et al.   JOURNAL OF MOLECULAR STRUCTURE

Rhodanine‐Furan Bis‐Heterocyclic Frameworks Synthesis via Green One‐Pot Sequential Six‐Component Reactions: A Synthetic and Computational Study

(2019) Seyyed Emad Hooshmand et al.   ChemistrySelect

Derivatives of pyridine and thiazole hybrid: Synthesis, DFT, biological evaluation via antimicrobial and DNA cleavage activity

(2019) Serpil Eryılmaz et al.   BIOORGANIC CHEMISTRY

1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

(2019) Zhi Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole-containing compounds as therapeutic targets for cancer therapy

(2019) Prabodh Chander Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

(2019) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advancements in 1,4-Disubstituted 1H-1,2,3-Triazoles as Potential Anticancer Agents

(2018) Kashmiri Lal et al.   Anti-Cancer Agents in Medicinal Chemistry

Conventional and microwave-assisted synthesis of new indole-tethered benzimidazole-based 1,2,3-triazoles and evaluation of their antimycobacterial, antioxidant and antimicrobial activities

(2018) Dongamanti Ashok et al.   MOLECULAR DIVERSITY

Synthesis and antimicrobial evaluation of novel 1,2,4-triazole thioether derivatives bearing a quinazoline moiety

(2018) Zhijiang Fan et al.   MOLECULAR DIVERSITY

Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus

(2018) Srikanth Gatadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Review on Recent Synthetic Strategies and Pharmacological Importance of 1,3-Thiazole Derivatives

(2018) Swarna Gowri et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study

(2018) Mina Saeedi et al.   BIOORGANIC CHEMISTRY

Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles

(2017) Pinki Yadav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted synthesis, antioxidant and antimicrobial evaluation of 2-indolinone-based bis-1,2,3-triazole derivatives

(2017) Dongamanti Ashok et al.   MOLECULAR DIVERSITY

Synthesis of Some Novel 1,4-Phenylene-bis-thiazolyl Derivatives and Their Anti-hypertensive α-blocking Activity Screening

(2016) Fathy M. Abdelrazek et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs

(2016) Mahmood-ul-Hassan Khan et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity

(2016) Ekhlass M. Nassar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

(2014) Ravi Kant Upadhyay   Biomed Research International

Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

(2013) Shrikanth Ulloora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of amino acid-linked 1,2,3-bistriazole conjugates as potential antimicrobial agents

(2013) C. P. Kaushik et al.   MEDICINAL CHEMISTRY RESEARCH

Combinatorial Synthesis of Oxazol-Thiazole Bis-Heterocyclic Compounds

(2013) Siva Murru et al.   ACS Combinatorial Science

The Clinical Relevance of Plasma Protein Binding Changes

(2012) Jason A. Roberts et al.   CLINICAL PHARMACOKINETICS

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

(2012) Feixiong Cheng et al.   Journal of Chemical Information and Modeling

Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes

(2012) Zhigang Xu et al.   MOLECULAR DIVERSITY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Use ofN‐Methylpiperazine for the Preparation of Piperazine‐Based Unsymmetrical Bis‐Ureas as Anti‐HIV Agents

(2008) Ayman El‐Faham et al.   ChemMedChem

Prediction of Human Intestinal Absorption by GA Feature Selection and Support Vector Machine Regression

(2008) Aixia Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES