Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice

Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury

(2020) Chenxia Hu et al.   Stem Cell Research & Therapy

Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver

(2020) Ya-ru Xue et al.   ACTA PHARMACOLOGICA SINICA

Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation

(2020) Youzhe Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

(2020) Suvesh Munakarmi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: more friend than foe

(2020) Xiaofei Fan et al.   PHARMACOLOGICAL RESEARCH

Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system

(2020) Katherine Roth et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Anti-liver fibrosis effect of total flavonoids from Scabiosa comosa Fisch. ex Roem. et Schult. on liver fibrosis in rat models and its proteomics analysis

(2020) Menggensilimu et al.   Annals of Palliative Medicine

Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation

(2020) Xue Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS

(2020) Aaron Hilliard et al.   JOURNAL OF NEUROIMMUNOLOGY

Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity

(2020) Yu-Hsien Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

22-Oxocholestane oximes as potential anti-inflammatory drug candidates

(2019) Reyna Zeferino-Díaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cudrania Tricuspidata Extract and Its Major Constituents Inhibit Oxidative Stress-Induced Liver Injury

(2019) Sam Seok Cho et al.   JOURNAL OF MEDICINAL FOOD

Assessment of Serious Acute and Chronic Idiosyncratic Drug-Induced Liver Injury in Clinical Practice

(2019) Fernando Bessone et al.   SEMINARS IN LIVER DISEASE

Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats

(2019) Yongsheng Li et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches

(2019) Jelica Vucicevic et al.   CURRENT MEDICINAL CHEMISTRY

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

(2019) Rickinder Sethi et al.   Frontiers in Psychiatry

Hepatoprotective Effect of the Ethanol Extract of Illicium henryi against Acute Liver Injury in Mice Induced by Lipopolysaccharide

(2019) Islam et al.   Antioxidants

Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy pathway

(2019) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Severe liver injury due to herbal and dietary supplements and the role of liver transplantation

(2019) Priya Grewal et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives

(2018) Ai-Ling Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents

(2018) Hai-bin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

Synthesis of new ent-labdane diterpene derivatives from andrographolide and evaluation of their anti-inflammatory activities

(2018) Wang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity

(2017) Liu Zeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

(2017) Jawaid Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent

(2017) Hai-Wen Ding et al.   FITOTERAPIA

Hepatoprotective Effects of Kaempferol-3-O-α-l-Arabinopyranosyl-7-O-α-l-Rhamnopyranoside on d-Galactosamine and Lipopolysaccharide Caused Hepatic Failure in Mice

(2017) Lin Dong et al.   MOLECULES

Novel synthesis of steroidal oximes and lactams and their biological evaluation as antiproliferative agents

(2017) Roxana Martínez-Pascual et al.   STEROIDS

Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl 4 -induced acute liver injury and LPS-treated RAW264.7 cells

(2017) Xin Chen et al.   TOXICOLOGY LETTERS

Pharmacological Activities and Applications of Spicatoside A

(2016) Mahesh Ramalingam et al.   Biomolecules & Therapeutics

A HPLC–MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study

(2016) Chenlin Shen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Influencing COX-2 Activity by COX Related Pathways in Inflammation and Cancer

(2016) Tingting Yu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Vinyl Chloride Metabolites Potentiate Inflammatory Liver Injury Caused by LPS in Mice

(2016) Lisanne C. Anders et al.   TOXICOLOGICAL SCIENCES

Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats

(2015) Chenlin Shen et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

(2015) Maria Grazia Perrone et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis

(2014) Yoon Seok Choi et al.   GUT

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

Synthesis of novel 1,2,3-triazole based benzoxazolinones: Their TNF-α based molecular docking with in-vivo anti-inflammatory, antinociceptive activities and ulcerogenic risk evaluation

(2013) Saqlain Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives

(2012) Shalom Pôrto de Oliveira Assis et al.   TheScientificWorldJOURNAL

Flavonoids with an Oligopolysulfated Moiety: A New Class of Anticoagulant Agents

(2010) Marta Correia-da-Silva et al.   JOURNAL OF MEDICINAL CHEMISTRY