Anti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

(2021) Qiqi Feng et al.   International Journal of Nanomedicine

Design, synthesis of new anti-inflammatory agents with a pyrazole core: COX-1/COX-2 inhibition assays, anti-inflammatory, ulcerogenic, histopathological, molecular Modeling, and ADME studies

(2021) Khaled R.A. Abdellatif et al.   JOURNAL OF MOLECULAR STRUCTURE

Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review

(2020) Mohit Arora et al.   LIFE SCIENCES

Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety

(2020) Begüm Nurpelin Sağlık et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of isoxazole derivatives of tetrahydrofuran neolignans on intracellular amastigotes of Leishmania ( Leishmania ) amazonensis : A structure–activity relationship comparative study with triazole‐neolignan‐based compounds

(2019) Amarith R. Neves et al.   Chemical Biology & Drug Design

New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies

(2019) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs

(2018) Ingvar Bjarnason et al.   GASTROENTEROLOGY

Design, synthesis and antitrypanosomatid activities of 3,5-diaryl-isoxazole analogues based on neolignans veraguensin, grandisin and machilin G

(2018) Ozildéia S. Trefzger et al.   Chemical Biology & Drug Design

Anti-inflammatory activity of triazine derivatives: A systematic review

(2018) Laura Marín-Ocampo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Docking of THPDTPI: to explore P-selectin as a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent

(2017) Haimei Zhu et al.   Oncotarget

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Platelet activating factor: A potential biomarker in acute coronary syndrome?

(2016) Anand Vijaya Kumar Palur Ramakrishnan et al.   Cardiovascular Therapeutics

Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: a meta-analysis

(2016) B. R. Gunter et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety

(2016) Catarina Pereira-Leite et al.   MEDICINAL RESEARCH REVIEWS

Antileishmanial Activity and Structure-Activity Relationship of Triazolic Compounds Derived from the Neolignans Grandisin, Veraguensin, and Machilin G

(2016) Eduarda Costa et al.   MOLECULES

Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors

(2015) Deepak Lokwani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

(2015) Rajeshwary Ghosh et al.   Oxidative Medicine and Cellular Longevity

New click-chemistry methods for 1,2,3-triazoles synthesis: recent advances and applications

(2015) Jane Totobenazara et al.   TETRAHEDRON LETTERS

Preeclampsia: Integrated network model of platelet biomarkers interaction as a tool to evaluate the hemostatic/immunological interface

(2014) Letícia Gonçalves Freitas et al.   CLINICA CHIMICA ACTA

Targeting P-Selectin During Coronary Interventions

(2013) Fernando Alfonso et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anti-inflamatórios não esteroides: Efeitos cardiovasculares, cérebro-vasculares e renais

(2011) Michel Batlouni   Arquivos Brasileiros de Cardiologia

Severe acute liver injury associated with lumiracoxib

(2011) Peter I Pillans et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase

(2011) Sung Hee Hwang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

(2010) Jane L. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Progress in COX-2 Inhibitors: A Journey So Far

(2010) Asit Chakraborti et al.   CURRENT MEDICINAL CHEMISTRY

An asymmetric route to total synthesis of the furano lignan (+)-veraguensin

(2010) Kiran Matcha et al.   TETRAHEDRON LETTERS

Antinociceptive and antiinflammatory activities of grandisin extracted fromVirola surinamensis

(2009) Adryano A. V. Carvalho et al.   PHYTOTHERAPY RESEARCH

Celecoxib inhibits 5-lipoxygenase

(2008) Thorsten J. Maier et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?

(2008) John L. Wallace   PHYSIOLOGICAL REVIEWS