The impact of click chemistry in medicinal chemistry

Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry

(2011) Pardeep Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bivalent Dopamine D2Receptor Ligands: Synthesis and Binding Properties

(2011) Julia Kühhorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues

(2010) Laura B. Peterson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In situ click chemistry: probing the binding landscapes of biological molecules

(2010) Sreeman K. Mamidyala et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach

(2010) Amol H. Kategaonkar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Click-Chemistry-Derived Triazole Ligands of Arginine−Glycine−Aspartate (RGD) Integrins with a Broad Capacity To Inhibit Adhesion of Melanoma Cells and Both in Vitro and in Vivo Angiogenesis

(2010) Andrea Trabocchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of DOTA-Conjugated Multimeric [Tyr3]Octreotide Peptides via a Combination of Cu(I)-Catalyzed “Click” Cycloaddition and Thio Acid/Sulfonyl Azide “Sulfo-Click” Amidation and Their in Vivo Evaluation

(2010) Cheng-Bin Yim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

(2010) Katrien Brak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules

(2009) Basab Roy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Click chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivatives

(2009) Debendra K. Mohapatra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Growing Applications of “Click Chemistry” for Bioconjugation in Contemporary Biomedical Research

(2009) Kido Nwe et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones

(2009) Oludotun A. Phillips et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Application of Huisgen (3+2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobenzofuran-2-yl-methyl [1,2,3]-triazoles and their antitubercular evaluations

(2009) Rama P. Tripathi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

(2009) Stanislav A. Bakunov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole

(2008) Namdev S. Vatmurge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Stable Aminoacyl-tRNA Analogues Containing Triazole as a Bioisoster of Esters

(2008) Maryline Chemama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Histone Deacetylase Inhibitors through Click Chemistry

(2008) Jie Shen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide

(2008) Graham Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-β-lactam

(2008) Namdev S. Vatmurge et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of novel oxazolidinone antimicrobial agents

(2007) David C. Ebner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS