First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa

Effect of Osocimab in Preventing Venous Thromboembolism Among Patients Undergoing Knee Arthroplasty

(2020) Jeffrey I. Weitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Therapeutic strategies for thrombosis: new targets and approaches

(2020) Nigel Mackman et al.   NATURE REVIEWS DRUG DISCOVERY

Appropriateness of initial dose of non-vitamin K antagonist oral anticoagulants in patients with non-valvular atrial fibrillation in the UK

(2019) Luis Alberto García Rodríguez et al.   BMJ Open

Factor XI as a Therapeutic TargetHighlights

(2016) David Gailani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation

(2016) A John Camm et al.   HEART

Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis

(2016) Tovo David et al.   Science Translational Medicine

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

(2014) Jonathan W. Yau et al.   BLOOD

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

(2013) Jeffrey R. Crosby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Assessing bleeding risk in patients taking anticoagulants

(2013) Marwa Shoeb et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model

(2013) Maurits L. van Montfoort et al.   THROMBOSIS AND HAEMOSTASIS

Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys

(2012) H. S. Younis et al.   BLOOD

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

(2010) H. Zhang et al.   BLOOD

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

(2010) Ophira Salomon et al.   THROMBOSIS AND HAEMOSTASIS

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

(2008) E. I. Tucker et al.   BLOOD