Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity

In the Search of Glycoside-Based Molecules as Antidiabetic Agents

(2019) Aleksandra Pałasz et al.   Topics in Current Chemistry

Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity

(2018) Juan Cen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors

(2018) Gaochan Wu et al.   MedChemComm

Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors

(2018) Zbigniew Dutkiewicz et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

(2017) Bilqees Sameem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Synthesis, Characterization, and Biological Evaluation of Some Novel Glycosyl 1,3,4-Thiadiazole Derivatives as Acetylcholinesterase Inhibitors

(2015) Wei-wei Liu et al.   HETEROCYCLES

Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease

(2015) Fei Mao et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

(2015) Eugenie Nepovimova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional Tacrine Derivatives in Alzheimer’s Disease

(2014) Anna Minarini et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease

(2013) Alejandro Romero et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity

(2013) Fei Mao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of glucose-tagged triazolium ionic liquids and their application as solvent and ligand for copper(I) catalyzed amination

(2013) Abadh Kishor Jha et al.   TETRAHEDRON LETTERS

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Possible Role of Hydroxylated Metabolites of Tacrine in Drug Toxicity and Therapy of Alzheimers Disease

(2008) Jiri Patocka et al.   CURRENT DRUG METABOLISM

Prevalence of dementia after age 90: Results from The 90+ Study

(2008) M. M. Corrada et al.   NEUROLOGY