Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions

Targeting Asexual and Sexual Blood Stages of Human Malaria Parasite P. falciparum with 7-Chloroquinoline based [1,2,3]-Triazoles

(2019) Mahendra Nath et al.   ChemMedChem

Triazole derivatives and their antiplasmodial and antimalarial activities

(2019) Xue-Mei Chu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents

(2019) Guang Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents

(2019) Pramod V. Chavan et al.   BIOORGANIC CHEMISTRY

Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids

(2019) Bo Zhang   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted, rapid synthesis of 2-vinylquinolines and evaluation of their antimalarial activity

(2019) Guang Huang et al.   TETRAHEDRON LETTERS

Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria

(2019) Aysun Çapcı et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold

(2019) Matteo Staderini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs

(2019) Guo-qing Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids

(2019) Feng Gao et al.   BIOORGANIC CHEMISTRY

Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

(2019) Ana Cristina Lima Leite et al.   CURRENT MEDICINAL CHEMISTRY

Thiazolidinediones as antidiabetic agents: A critical review

(2018) M.J. Nanjan et al.   BIOORGANIC CHEMISTRY

Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile

(2018) Susana M.M. Lopes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrazolo[3,4- d ]pyrimidin-4(5 H )-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents

(2018) Muralidhar Allam et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance

(2018) Bo Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

(2018) Poonam et al.   MEDICINAL RESEARCH REVIEWS

ProTox-II: a webserver for the prediction of toxicity of chemicals

(2018) Priyanka Banerjee et al.   NUCLEIC ACIDS RESEARCH

Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations

(2018) Kongkai Zhu et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents

(2018) Yu Ke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

(2018) Piyush N. Kalaria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus

(2018) Srikanth Gatadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

(2018) Leila S. Ross et al.   Nature Communications

Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents

(2018) Kasa Shiva Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

(2017) Diego G. Ghiano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline hybrids and their antiplasmodial and antimalarial activities

(2017) Yuan-Qiang Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry

(2017) Danylo Kaminskyy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimalarial activity, heme binding and docking studies of N -substituted 4-aminoquinoline-pyrimidine molecular hybrids

(2017) Shiv Shyam Maurya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study

(2017) Magda A.-A. El-Sayed et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle

(2017) Bracken F. Roberts et al.   International Journal for Parasitology-Drugs and Drug Resistance

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

(2016) Bracken F. Roberts et al.   International Journal for Parasitology-Drugs and Drug Resistance

In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine

(2015) Lebusetsa Taleli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2

(2015) Rajni Kant Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and optimisation studies of antimalarial phenotypic hits

(2015) Alka Mital et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

(2015) Liang Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation

(2015) Anil K. Singh et al.   PLoS One

Synthesis of novel triazole-linked mefloquine derivatives: Biological evaluation against Plasmodium falciparum

(2014) Anton R. Hamann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Compounds Hybrids 1H-1,2,3-Triazole-Quinoline AgainstPlasmodium falciparum

(2014) Núbia Boechat et al.   Chemical Biology & Drug Design

Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring

(2013) Yakaiah Chinthala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azide-alkyne cycloaddition en route to 1 H -1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation

(2013) Raghu Raj et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

7-Chloroquinolinotriazoles: Synthesis by the azide–alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies

(2013) Guilherme R. Pereira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plasmodium falciparum: Generation of pure gametocyte culture by heparin treatment

(2013) Jun Miao et al.   EXPERIMENTAL PARASITOLOGY

Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth

(2012) Alexander P. Gorka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines

(2012) Vladimir V. Kouznetsov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?

(2012) Christopher L Peatey et al.   MALARIA JOURNAL

Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry

(2011) Pardeep Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine Hybrids as Potential Antimalarial Agents

(2011) Sunny Manohar et al.   Chemical Biology & Drug Design

A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions

(2011) Yizhe Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

(2010) Eric M. Guantai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

(2009) Stanislav A. Bakunov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interplay Between Malaria, Crystalline Hemozoin Formation, and Antimalarial Drug Action and Design

(2008) Isabelle Weissbuch et al.   CHEMICAL REVIEWS

Plasmodium falciparum: Development of a transgenic line for screening antimalarials using firefly luciferase as the reporter

(2008) Long Cui et al.   EXPERIMENTAL PARASITOLOGY

Synthesis of novel substituted 1,3-diaryl propenone derivatives and their antimalarial activity in vitro

(2007) Nidhi Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY