Article
Polymer Science
Quanliang Wang, Xudong Gao, Xin Jing, Yonghai Li, Kaili Zhang, Feng Li, Renqiang Yang, Liangmin Yu, Mingliang Sun
Summary: Designing and synthesizing new organic photovoltaic materials, such as naphtho [2,3-c]thiophene-4,9-dione (NTD), and its analogues, can significantly impact the photovoltaic potential of polymer solar cells (PSCs). Side-chain modification on NTD in this study resulted in the synthesis of two new D-A conjugated donor polymers, PBNO and PBNS, with enhanced power conversion efficiency. This work demonstrates that analogues of excellent molecules have huge photovoltaic potential and side-chain modification plays a significant role in improving the photovoltaic performance of PSCs.
Article
Chemistry, Medicinal
Meena Devi, Parvin Kumar, Rahul Singh, Jayant Sindhu, Ramesh Kataria
Summary: In this study, the inhibitory action of 1,4-naphthoquinone, imidazole, and 1,2,3-triazole motifs on alpha-amylase enzyme was synergized by incorporating them into a single matrix. A series of novel naphtho[2,3-d]imidazole-4,9-dione appended 1,2,3-triazoles were synthesized and their chemical structures were determined. The derivatives showed alpha-amylase inhibitory activity, with compounds containing -OCH3 and -NO2 groups showing the highest inhibition potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Meena Devi, Parvin Kumar, Rahul Singh, Jayant Sindhu, Ashwani Kumar, Sohan Lal, Devender Singh, Harish Kumar
Summary: In this study, a series of novel compounds were synthesized and evaluated for their conformation and a-amylase inhibitory activity. Compound H6 showed the highest activity among the tested compounds. Structure-activity relationship analysis indicated that variable substitution at the aryl ring played a crucial role in determining the inhibitory action of these compounds. Docking simulations and metabolism prediction confirmed the potential of H6 as a treatment for Type 2 diabetes.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Yung-Sheng Yen, Jui-Ling Hsu, Jen-Shyang Ni, Jiann T. Lin
Summary: Three metal-free sensitizers based on the D-A'-pi-A structure were developed for dye-sensitized solar cells, showing strong light-capturing ability and high molar extinction coefficients in the visible region. The DSSCs using these sensitizers exhibited conversion efficiencies ranging from 5.85% to 6.91%, with the HJL-3 dye achieving 7.17% after coadsorption with CDCA, approximately 95% of the N719-based standard cell performance.
Article
Biochemistry & Molecular Biology
Hongbo Tan, Zehui Qi, Yuanhui Yu, Xu Zhang, Yuheng Xiang, Jingwen Huang, Zhigang Xu, Dianyong Tang, Zhongzhu Chen, Bochu Wang
Summary: A visible-light-mediated [3+2] cycloaddition reaction has been developed for the synthesis of important naphtho[2,3-b]furan-4,9-dione compounds. This new method offers a powerful, green, efficient, and facile means to expand the structural diversity of these compounds as promising scaffolds for novel drug discovery. It demonstrates excellent regioselectivity and remarkable functional group tolerance, delivering a variety of target compounds in good yields under environmentally friendly conditions.
Article
Biochemistry & Molecular Biology
Shuyi Zhou, Xixi Hou, Ling Li, LiHao Guo, Huili Wang, Longfei Mao, Leilei Shi, Miaomiao Yuan
Summary: Prostate cancer is the second most frequently diagnosed cancer among men, and traditional chemotherapy for PCa has limited efficacy. A study found that the drug dolutegravir, commonly used to treat HIV, and its derivatives have the potential to treat prostate cancer by inhibiting tumor cell proliferation and having minimal impact on normal cells.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Hong-bo Tan, Xu Zhang, Yu-heng Xiang, Jing-wen Huang, Zhi-gang Xu, Dian-yong Tang, Zhong-zhu Chen, Bo-chu Wang
Summary: This article describes an efficient, concise, and green visible-light-mediated [3 + 2] cycloaddition reaction for the diastereoselective synthesis of naphtho[2,3-b]furan-4,9-diones starting from readily available 2-hydroxy-1,4-naphthoquinones and alkynes without any bases, metals, ligands, or other catalysts. The products could be obtained under blue LED (460 nm) irradiation at ambient temperature in 6 h with perfect regioselectivity and remarkable functional group tolerance. This approach provides an original, powerful, green, efficient, and facile way to expand the structural diversity of compounds with the structure motifs of naphtho[2,3-b]furan-4,9-diones and dihydronaphtho[2,3-b]furan-4,9-diones as promising scaffolds for novel drug discovery.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Applied
Gabriel Monteze Ferreira, Ana Paula Braga Lima, Guilherme Rocha Pereira, Glenda Nicioli da Silva, Geraldo Celio Brandao
Summary: This study synthesized a novel naphthoquinone containing a hetero sulfur atom and found its antiproliferative activity on bladder cancer, regardless of TP53 status. In addition, the naphthoquinone also affected cell morphology, migration, oxidative stress, and cell cycle.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Denis S. Baranov, Alexander A. Popov, Danil A. Nevostruev, Alexey A. Dmitriev, Yurii Gatilov, Elena S. Kobeleva
Summary: The method described in this study efficiently synthesizes 2-R-naphtho[2,3-b]thiophene-4,9-diones via a series of reactions starting from 2-bromo-1,4-naphthoquinone and alkynes. The protocol offers mild reaction conditions, good functional group tolerance, and readily available starting materials.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Hong Xu, Bei Wang, Fu-Yu Li, Ji-Yu Wang
Summary: A series of novel carbazolequinones were efficiently obtained through a B(C6F5)3-catalyzed [4 + 2] cyclization reaction. This method not only had a simple operation, broad substrate range, and high atomic economy, but also had a low catalyst loading and avoided using metal catalysts. In addition, diverse new carbazole-fused compounds were constructed under different reduction conditions. The photophysical characterization results showed that the structure of carbazole-fused derivatives had a significant impact on the fluorescence properties.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kiran Siwach, Amit Kumar, Harish Panchal, Rajiv Kumar, Jitender Kumar Bhardwaj, Andrea Angeli, Claudiu T. Supuran, Pawan K. Sharma
Summary: In this study, two subsets of novel benzenesulphonamide compounds were designed and synthesized, which showed good inhibition activity against tumour-associated carbonic anhydrase IX. Some of these compounds also demonstrated interesting potential for inducing apoptosis in vitro.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Kotyada Suryanarayana, Suresh Maddila, Kerru Nagaraju, Sreekantha B. Jonnalagadda
Summary: The evolution of Click chemistry led to the synthesis of a contemporary library of 1,2,3-triazole-thieno[2,3-d]-pyrimidine derivatives, which showed promising antioxidant activity. Structure-activity relationship analysis was used to explore the impact of substituents on the aryl ring on the activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Nazariy Pokhodylo, Nataliya Finiuk, Olha Klyuchivska, Mykola A. Tupychak, Vasyl Matiychuk, Evgeny Goreshnik, Rostyslav Stoika
Summary: The N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides were synthesized using CDI as amide coupling reagents, and their antiproliferative potency towards different cell lines was evaluated. One compound with promising anticancer activity was selected for further studies as a biocompatible agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Meenakshi Duhan, Rahul Singh, Meena Devi, Jayant Sindhu, Parvin Kumar, Sudhir Kumar, Ramesh Kataria, Ashwani Kumar, Sohan Lal, Devender Singh
Summary: A series of 2,4-thiazolidinedione fused spiropyrrolidineoxindole and 1,2,3-triazole scaffolds were designed and synthesized for α-amylase inhibition. Compound 9b showed the highest inhibition with 88.05 +/- 2.51%, 76.65 +/- 2.19%, and 68.57 +/- 1.96% inhibition at 50, 25, and 12.5 mg mL(-1), respectively. Molecular docking and dynamic simulations confirmed the stability of the ligand-protein complexes.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Anil Kumar Sabhavath, Sarasija Madderla, Ravinder Dharavath, Vishnu Thumma, Gugulothu Thara, Srinivas Gundu, Ashok Dongamanti
Summary: This study describes a simple and convenient one-pot three-component method to synthesize 1,2,3-triazole-based 2,3-dihydrofuran derivatives. The method offers advantages such as high yield, short reaction time, and ease of operation, while using a green method and an eco-friendly catalyst. In vitro anticancer activity screening showed that most of the target compounds exhibited promising activity.
Review
Physics, Multidisciplinary
Sayantan Mazumdar, Ying Zhao, Xiaodan Zhang
Summary: Perovskite/silicon tandem solar cells (PSTSCs) have the potential to overcome the efficiency limit of single-junction silicon solar cells by combining the wider bandgap of a semitransparent perovskite solar cell (PSC) with the ability of a narrow bandgap silicon solar cell to convert infrared light. However, the actual efficiency of PSTSCs is currently below the theoretical limit, and challenges in stability and upscaling need to be addressed.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2023)
Article
Business
Chang Liu, Yinglan Zhao
Summary: This study investigates the impact of interest rates and interest rate distortion in China's shadow banking system on short-term capital flows. The results show that the spread of shadow banking interest rates and the degree of interest rate distortion have a nonlinear effect on short-term capital flows.
EMERGING MARKETS FINANCE AND TRADE
(2023)
Article
Environmental Sciences
Zhennan Lin, Shufeng Chen, Fangchao Liu, Jianxin Li, Jie Cao, Keyong Huang, Fengchao Liang, Jichun Chen, Hongfan Li, Jianfeng Huang, Dongsheng Hu, Chong Shen, Yingxin Zhao, Xiaoqing Liu, Ling Yu, Xiangfeng Lu, Dongfeng Gu
Summary: Long-term exposure to high levels of PM2.5 is associated with increased blood pressure and hypertension risk. In China, for each 10μg/m3 increase in PM2.5 concentration, systolic and diastolic blood pressure increased by 1.67mmHg and 0.45mmHg, respectively, and the prevalence of hypertension increased by 29%. The relationship between PM2.5 and blood pressure may be non-linear.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Qingmei Cui, Zhongying Liu, Jianxin Li, Fangchao Liu, Xiaoge Niu, Chong Shen, Dongsheng Hu, Keyong Huang, Shufeng Chen, Yingxin Zhao, Fanghong Lu, Xiaoqing Liu, Jie Cao, Laiyuan Wang, Hongxia Ma, Ling Yu, Xianping Wu, Ying Li, Huan Zhang, Xingbo Mo, Liancheng Zhao, Zhibin Hu, Hongbing Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: This study aims to examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations. The results showed that individuals with a favourable CVH profile demonstrated similar relative effects across Polygenic Risk Score (PRS) categories, reducing the CAD relative risk by a similar magnitude. Individuals with high PRS achieved the greatest benefit from favourable CVH, mitigating the risk to the average level of the population. Attaining favourable CVH should be encouraged for all individuals, especially those with high genetic susceptibility.
Article
Environmental Sciences
Yingying Zhao, Meng Su, Xin Meng, Jiying Liu, Faming Wang
Summary: This study evaluated the effects of environmental heat stress and personal cooling strategies on the physiological and perceptual responses of college students wearing personal protective equipment (PPE). The results showed that PPE can help mitigate heat stress, and the use of cooling systems can further reduce heat strain. The perceptual responses improved significantly with the use of personal cooling systems.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Xiaochen Zhu, Yingying Zhao, Hua Wei, Nan Hu, Qingbiao Hu, Yingdong Li
Summary: In this study, the complete mitochondrial genome of the poorly understood leech species Torix tukubana was sequenced using next-generation sequencing. The results showed that the mitogenome consisted of 13 protein-coding genes, 22 tRNAs, 2 rRNAs, and 1 control region. The phylogenetic analysis indicated that T. tukubana belonged to the monophyletic group of Glossiphoniidae, consistent with previous research.
Article
Chemistry, Multidisciplinary
Qian Ma, Sijing Wu, Ling Yang, Yaohua Wei, Chaoyong He, Wenshan Wang, Yingxin Zhao, Zhijian Wang, Shiwei Yang, Dongmei Shi, Yuyang Liu, Zhiming Zhou, Jiefang Sun, Yujie Zhou
Summary: This study aims to develop a new approach for active targeting of atherosclerotic plaques using nano-agents for imaging and treatment. The use of CD44-targeted HA-guided cerasomes results in significant plaque regression and improved magnetic resonance imaging. This safe and efficient nano-formulation has potential applications in the treatment of atherosclerosis.
Article
Food Science & Technology
Jie Ding, Ming Wang, Jiao Wu, Qiuying Li, Yingying Zhao, Jianrong Li, Tong Sun
Summary: This study investigates the effects of eugenol and its compound preservatives on the preservation and antioxidant properties of seasoned Lateolabrax japonicus fillets. The results show that eugenol and its compound-treated fish fillets have better freshness and texture compared to untreated and seasoned fillets. They also exhibit strong free radical scavenging ability, inhibit microbial growth, and prevent lipid and protein oxidation.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Energy & Fuels
Bingbing Chen, Yongliang Chen, Zhao Zhu, Guofu Hou, Qian Huang, Ying Zhao, Xiaodan Zhang
Summary: Perovskite solar cells (PSCs) have the potential for high-power conversion efficiency but are limited by interfacial energy-level mismatch and defects. A low-temperature-processed indium tin oxide (ITO-LT) cathode buffer layer is used to optimize energy-level alignment and suppress defects, leading to enhanced interfacial charge transfer.
Article
Chemistry, Multidisciplinary
Hongrui Sun, Sanlong Wang, Shanshan Qi, Pengyang Wang, Renjie Li, Biao Shi, Qixing Zhang, Qian Huang, Shengzhi Xu, Ying Zhao, Xiaodan Zhang
Summary: An innovative in-situ etching (ISE) method using methanol is proposed to reduce surface defects in inorganic perovskite solar cells (IPSCs). The treatment with methanol leads to a decrease in surface defects and the passivation of grain boundary defects, resulting in a reduction in trap density and improved charge carrier extraction. The efficiency of the IPSCs is enhanced from 16.00% to 19.34% using this method.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Food Science & Technology
Sijie Wu, Lu Wang, Yingying Zhao, Bilian Chen, Dan Qiu, Peilong Sun, Ping Shao, Simin Feng
Summary: The strength of bio-based hydrogels can be enhanced by incorporating whey protein nanofiber (WPN) into sodium alginate (SA) hydrogels. The SA/WPN double network hydrogels showed improved rheological and textural properties through electrostatic interactions. The addition of WPN increased the storage modulus, hardness, adhesiveness, and cohesiveness of the hydrogels. Curcumin was successfully encapsulated in the SA/WPN hydrogels through various interactions and resulted in changes in the crystalline state. These findings suggest that SA/WPN double network hydrogels have potential as carriers for hydrophobic bioactive substances.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Ecology
Cecilia Elizabeth Heuvel, Yingming Zhao, Aaron Thomas Fisk
Summary: Establishing a baseline for stable isotope studies is crucial for interpreting trophic relationships. Freshwater ecosystems face challenges in quantifying baseline stable isotopes due to difficulties in collecting representative samples. This study assessed temporal and spatial variation in stable isotopes in Lake Erie to understand the mechanism behind baseline stable isotope dynamics. The findings suggest that seasonal changes in system processes and plankton community dynamics influence stable isotopes in Lake Erie.
FRESHWATER BIOLOGY
(2023)
Article
Agronomy
Yingying Zhao, Deng Yan, Jinjing Liu, Shuzhen Yang, Dongmei Li, Litao Peng
Summary: In this study, the function of the vacuolar ATPase subunit H (VmaH) in Penicillium digitatum was characterized. The results showed that silencing the VmaH gene reduced cell growth and pathogenicity of P. digitatum, increased vacuolar pH and decreased extracellular pH. Furthermore, VmaH gene silencing inhibited the expression of transport genes and interfered with nutrient metabolic processing, leading to altered cell morphology and weakened pathogenicity.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Ying Zhao, Dong Yuan, Jia Tina Du, Jinjun Chen
Summary: Directional distribution analysis is essential for abstracting dispersion and orientation of spatial datasets, but it must be used cautiously to protect individuals' privacy. There is a tension between accurate directional distribution results and location privacy. In this paper, we propose a geo-ellipse-indistinguishability privacy notion to protect individual location data and present elliptical privacy mechanisms based on gamma distribution and multivariate normal distribution. The empirical evaluation shows that our proposed elliptical approach achieves significantly higher directional distribution utility compared to circular noise function based methods.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Juan-Juan Li, Rui-Xue Rong, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu, Ke-Rang Wang, Dong-Sheng Guo
Summary: Host-guest drug delivery systems (HGDDSs) have been studied to modify therapeutic agents and improve treatment effects. The targeting ability of HGDDSs needs continuous improvement for the development of precision medicine. In this study, a lactose-modified azocalix[4]arene (LacAC4A) was used as a triple targeting drug carrier for antitumor purposes. LacAC4A showed effective tumor growth suppression through passive targeting, active targeting, and stimuli-responsive targeting. This design principle provides a new material for drug delivery systems.
MATERIALS HORIZONS
(2023)