Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?
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Title
Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?
Authors
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Journal
Frontiers in Physiology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-10-04
DOI
10.3389/fphys.2021.730048
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- Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
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- Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
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- Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II
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- Diabetes mellitus and cancer risk: Review of the epidemiological evidence
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- Voltage-dependant anion channels: Novel insights into isoform function through genetic models
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- Hallmarks of Cancer: The Next Generation
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- Structure-based Analysis of VDAC1 Protein
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- Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse
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- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
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- Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
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- Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition
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- VDAC, a multi-functional mitochondrial protein regulating cell life and death
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- Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
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- Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study
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- Structure of the human voltage-dependent anion channel
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