α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

VDAC electronics: 1. VDAC-hexo(gluco)kinase generator of the mitochondrial outer membrane potential

(2014) Victor V. Lemeshko   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the α-Hemolysin Channel

(2014) Philip A. Gurnev et al.   BIOPHYSICAL JOURNAL

α-Synuclein amino terminus regulates mitochondrial membrane permeability

(2014) Jiamei Shen et al.   BRAIN RESEARCH

Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation

(2014) Marta Robotta et al.   CHEMBIOCHEM

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats

(2013) Lingling Lu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

(2013) Sabrina Büttner et al.   EMBO JOURNAL

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

α-Synuclein and Mitochondria: Partners in Crime?

(2013) Ken Nakamura   Neurotherapeutics

A Powerful Yeast Model to Investigate the Synergistic Interaction of α-Synuclein and Tau in Neurodegeneration

(2013) Gianmario Ciaccioli et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson’s disease models

(2012) S Büttner et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The role of VDAC in cell death: Friend or foe?

(2011) Kyle S. McCommis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VDAC inhibition by tubulin and its physiological implications

(2011) Tatiana K. Rostovtseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biophysics of α-synuclein membrane interactions

(2011) Candace M. Pfefferkorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tubulin-blocked state of VDAC studied by polymer and ATP partitioning

(2011) Philip A. Gurnev et al.   FEBS LETTERS

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VDAC, a multi-functional mitochondrial protein as a pharmacological target

(2011) Varda Shoshan-Barmatz et al.   MITOCHONDRION

Characterization of human VDAC isoforms: A peculiar function for VDAC3?

(2010) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells

(2010) E. N. Maldonado et al.   CANCER RESEARCH

α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease

(2010) Kalpita Banerjee et al.   FEBS LETTERS

Tryptophan Probes at the α-Synuclein and Membrane Interface

(2010) Candace M. Pfefferkorn et al.   JOURNAL OF PHYSICAL CHEMISTRY B

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast

(2008) Sabrina Büttner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial alterations in Parkinson’s disease: new clues

(2008) Miquel Vila et al.   JOURNAL OF NEUROCHEMISTRY

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Enhanced translocation of single DNA molecules through  -hemolysin nanopores by manipulation of internal charge

(2008) G. Maglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

(2008) T. K. Rostovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA