Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated States

A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis

(2018) Avijit Paul et al.   MOLECULAR THERAPY

Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells

(2017) Patrick D. Rädler et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties

(2017) Tasleem Arif et al.   NEURO-ONCOLOGY

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target

(2017) Amadou K. S. Camara et al.   Frontiers in Physiology

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation

(2016) Tasleem Arif et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

(2015) Kensuke Tateishi et al.   CANCER CELL

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

(2015) Glenn Simmons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma: Molecular Pathways, Stem Cells and Therapeutic Targets

(2015) Meena Jhanwar-Uniyal et al.   Cancers

Glioblastoma stem-like cells: at the root of tumor recurrence and a therapeutic target

(2014) Melanie Jackson et al.   CARCINOGENESIS

Who controls the ATP supply in cancer cells? Biochemistry lessons to understand cancer energy metabolism

(2014) Rafael Moreno-Sánchez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability

(2014) E Martín-Villar et al.   ONCOGENE

Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo

(2014) Tasleem Arif et al.   Molecular Therapy-Nucleic Acids

Mitochondrial Translocation of p53 Modulates Neuronal Fate by Preventing Differentiation-Induced Mitochondrial Stress

(2013) Joana M. Xavier et al.   ANTIOXIDANTS & REDOX SIGNALING

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

ALDH1-Positive Cancer Stem Cells Predict Engraftment of Primary Breast Tumors and Are Governed by a Common Stem Cell Program

(2013) E. Charafe-Jauffret et al.   CANCER RESEARCH

AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors

(2013) M. Rios et al.   CANCER RESEARCH

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

(2013) Murielle Mimeault et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain tumor stem cells: Molecular characteristics and their impact on therapy

(2013) David L. Schonberg et al.   MOLECULAR ASPECTS OF MEDICINE

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Human breast and melanoma cancer stem cells biomarkers

(2012) Caterina A.M. La Porta et al.   CANCER LETTERS

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Non-apoptotic functions of apoptosis-regulatory proteins

(2012) Lorenzo Galluzzi et al.   EMBO REPORTS

The Cancer Stem-Cell Hypothesis: Its Emerging Role in Lung Cancer Biology and Its Relevance for Future Therapy

(2012) John D. O’Flaherty et al.   Journal of Thoracic Oncology

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Lessons from human teratomas to guide development of safe stem cell therapies

(2012) Justine J Cunningham et al.   NATURE BIOTECHNOLOGY

Podoplanin: emerging functions in development, the immune system, and cancer

(2012) Jillian L. Astarita et al.   Frontiers in Immunology

Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease

(2011) Jason R. Rock et al.   Annual Review of Cell and Developmental Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Recent Advances in p53 Research and Cancer Treatment

(2011) Kazufumi Suzuki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

VDAC, a multi-functional mitochondrial protein as a pharmacological target

(2011) Varda Shoshan-Barmatz et al.   MITOCHONDRION

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Pathway inhibition: emerging molecular targets for treating glioblastoma

(2011) W. Wick et al.   NEURO-ONCOLOGY

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

(2010) Rodrigo Diaz-Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Downregulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivo

(2010) Inbar Koren et al.   CANCER BIOLOGY & THERAPY

Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity

(2010) Lin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures

(2010) Shuangping Zhao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Combination therapy targeting cancer metabolism

(2010) Justin B. Wenger et al.   MEDICAL HYPOTHESES

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

(2010) Olga Méndez et al.   Molecular Cancer

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Metabolic benefits from Sirt1 and Sirt1 activators

(2009) Nilika Chaudhary et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Caspase-8 deficiency facilitates cellular transformation in vitro

(2008) Y Krelin et al.   CELL DEATH AND DIFFERENTIATION

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A non-apoptotic role for caspase-9 in muscle differentiation

(2008) T. V. A. Murray et al.   JOURNAL OF CELL SCIENCE