Metformin and Its Benefits for Various Diseases

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

(2019) Jiyoung Lee et al.   NATURE

Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice

(2019) Iara Karise et al.   BIOMEDICINE & PHARMACOTHERAPY

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial

(2019) Mohapradeep Mohan et al.   EUROPEAN HEART JOURNAL

The rise and fall of aspirin in the primary prevention of cardiovascular disease

(2019) Inbar Raber et al.   LANCET

The multifaceted effects of metformin on tumor microenvironment

(2019) Ivana Kurelac et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Comparing the individual effects of metformin and rosiglitazone and their combination in obese women with polycystic ovary syndrome: a randomized controlled trial

(2019) Yujing Li et al.   FERTILITY AND STERILITY

Combination Glucose-Lowering Therapy Plans in T2DM: Case-Based Considerations

(2018) Lawrence Blonde et al.   ADVANCES IN THERAPY

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro

(2018) Peter Breining et al.   DIABETES OBESITY & METABOLISM

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

(2018) Mardiana Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder

(2018) Ellen Neven et al.   KIDNEY INTERNATIONAL

Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression

(2018) Ke Li et al.   ONCOGENE

Metabolic Effects of Metformin in the Failing Heart

(2018) Aleksandra Dziubak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics

(2018) Bram Stynen et al.   CELL

A Gut Feeling for Metformin

(2018) David Z.I. Cherney et al.   Cell Metabolism

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Corrigendum: Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism

(2018) Yufeng Lin et al.   Frontiers in Aging Neuroscience

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Metformin – its potential anti-cancer and anti-aging effects

(2017) Monika Podhorecka et al.   Postepy Higieny I Medycyny Doswiadczalnej

Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study

(2017) Samira Bell et al.   BMC Nephrology

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

(2017) et al.   JAMA Oncology

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

New Definition of Aging?

(2016) Douglas W. Losordo et al.   CIRCULATION RESEARCH

Empagliflozin as Add-on Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Linagliptin and Metformin: A 24-Week Randomized, Double-Blind, Parallel-Group Trial

(2016) Eirik Søfteland et al.   DIABETES CARE

Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naïve Type 2 Diabetes

(2016) Julio Rosenstock et al.   DIABETES CARE

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

(2016) Eun Kyung Kim et al.   MEDIATORS OF INFLAMMATION

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Metformin in Cancer Treatment and Prevention

(2015) Daniel R. Morales et al.   Annual Review of Medicine

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

(2015) S Jagannathan et al.   LEUKEMIA

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

(2015) Xinbing Sui et al.   MOLECULAR PHARMACEUTICS

Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis

(2015) Shuyan Gu et al.   PLoS One

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle

(2014) Jonas Møller Kristensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders

(2014) S. Gandini et al.   Cancer Prevention Research

Breast Cancer: Epidemiology and Etiology

(2014) ZiQi Tao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

(2014) Min Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

AKT as a therapeutic target in multiple myeloma

(2014) Niamh A Keane et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Anti-Diabetic Medications and the Risk of Hepatocellular Cancer: A Systematic Review and Meta-Analysis

(2013) Siddharth Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Metformin is associated with improved survival in endometrial cancer

(2013) Emily M. Ko et al.   GYNECOLOGIC ONCOLOGY

Cutaneous melanoma

(2013) Alexander MM Eggermont et al.   LANCET

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

(2013) Cesare Patrone et al.   Lancet Diabetes & Endocrinology

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics?

(2012) Matthew Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Acute kidney injury and chronic kidney disease: an integrated clinical syndrome

(2012) Lakhmir S. Chawla et al.   KIDNEY INTERNATIONAL

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

(2012) Giovanni Blandino et al.   Nature Communications

The Use of Simulation for Pediatric Oncology Nursing Safety Principles: Ensuring Competent Practice Through the Use of a Mnemonic, Chemotherapy Road Maps and Case-Based Learning

(2012) Luanne Linnard-Palmer   Journal of Pediatric Nursing-Nursing Care of Children & Families

The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia

(2011) R. Polak et al.   BLOOD

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A meta-analysis

(2011) Z.-J. Zhang et al.   DIABETES CARE

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hepatotoxicity Associated with Metformin Therapy in Treatment of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease

(2010) Catherine J Cone et al.   ANNALS OF PHARMACOTHERAPY

AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts

(2010) Young-Sun Lee et al.   BONE

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials

(2010) C. Lamanna et al.   DIABETES OBESITY & METABOLISM

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Metformin versus Insulin for the Treatment of Gestational Diabetes

(2008) Janet A. Rowan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

(2008) L. Raffaghello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA