AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway

(2016) Nicola J. Maclaine et al.   Aging-US

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Adipose Tissue, Inflammation and Atherosclerosis

(2011) Birgit Gustafson   Journal of Atherosclerosis and Thrombosis

Linking the inflammasome to obesity-related disease

(2011) Tiffany Horng et al.   NATURE MEDICINE

AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction

(2010) Subat Turdi et al.   AGING CELL

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

(2010) Bharat B. Aggarwal   Annual Review of Nutrition

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

(2010) Marie-Soleil Gauthier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

AMP-activated protein kinase and its downstream transcriptional pathways

(2010) Carles Cantó et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging

(2010) Antero Salminen et al.   CELLULAR SIGNALLING

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

(2010) Sarah Hummasti et al.   CIRCULATION RESEARCH

AMPKα2 Deletion Causes Aberrant Expression and Activation of NAD(P)H Oxidase and Consequent Endothelial Dysfunction In Vivo

(2010) Shuangxi Wang et al.   CIRCULATION RESEARCH

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

(2010) Y. Dong et al.   DIABETES

p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

(2010) Prashanth Ak et al.   FASEB JOURNAL

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

(2010) Zhijun Luo et al.   Future Oncology

5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB

(2010) Marina Katerelos et al.   IMMUNOLOGY AND CELL BIOLOGY

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

(2010) Zhiyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of AMP-activated Protein Kinase α1 Alleviates Endothelial Cell Apoptosis by Increasing the Expression of Anti-apoptotic Proteins Bcl-2 and Survivin

(2010) Chao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF- B

(2010) X. D. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

(2010) E H Jeninga et al.   ONCOGENE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

AMPK activators - potential therapeutics for metabolic and other diseases

(2009) G. Zhou et al.   Acta Physiologica

Genetics vs. entropy: Longevity factors suppress the NF-κB-driven entropic aging process

(2009) Antero Salminen et al.   AGEING RESEARCH REVIEWS

AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells

(2009) Michael M. Myerburg et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

AMPK and the biochemistry of exercise: implications for human health and disease

(2009) Erik A. Richter et al.   BIOCHEMICAL JOURNAL

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

(2009) S. Fogarty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

Adiponectin, an Unlocking Adipocytokine

(2009) Yiyi Sun et al.   Cardiovascular Therapeutics

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

(2009) Aaron K. F. Wong et al.   CLINICAL SCIENCE

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

(2009) H. J. Ko et al.   DIABETES

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

(2009) Wen Zhou et al.   GASTROENTEROLOGY

NF-κB Signaling in the Aging Process

(2009) Antero Salminen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Oxidative stress and metabolic syndrome

(2009) Christian K. Roberts et al.   LIFE SCIENCES

The role of proliferator-activated receptor γ coactivator–1α in the fatty-acid–dependent transcriptional control of interleukin-10 in hepatic cells of rodents

(2009) Joseane Morari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

AICAR (5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures

(2009) Krzysztof Łabuzek et al.   NEUROTOXICOLOGY

AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

(2009) Jin-Taek Hwang et al.   New Biotechnology

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Loss of p53 enhances catalytic activity of IKK  through O-linked  -N-acetyl glucosamine modification

(2009) K. Kawauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Endoplasmic reticulum: nutrient sensor in physiology and pathology

(2009) József Mandl et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury

(2008) Xia Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

(2008) Xavier Palomer et al.   CARDIOVASCULAR RESEARCH

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

(2008) Z. Xie et al.   DIABETES

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-κB activation in vascular endothelial cells

(2008) Yoshiyuki Hattori et al.   FEBS LETTERS

Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation

(2008) Nan-Lan Huang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+Entry via TRPC Channels Is Necessary for Thrombin-induced NF-κB Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase Cδ

(2008) Angela M. Bair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

(2008) Patrick Narbonne et al.   NATURE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Foxo in the immune system

(2008) S L Peng   ONCOGENE

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model

(2007) Monika Madan et al.   ATHEROSCLEROSIS