Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Regulation of B cell fate, survival, and function by mitochondria and autophagy

(2018) Hector Sandoval et al.   MITOCHONDRION

Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells

(2018) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase

(2017) Wei-Lun Tsai et al.   Oncotarget

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

(2017) Richard Furie et al.   Arthritis & Rheumatology

Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems

(2017) Sameer S. Udhane et al.   Scientific Reports

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Human effector B lymphocytes express ARID3a and secrete interferon alpha

(2016) Julie M. Ward et al.   JOURNAL OF AUTOIMMUNITY

Effect of metformin on global gene expression in liver of KKAy mice

(2016) Zhi-Qin Liu et al.   Pharmacological Reports

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

(2016) Laura Negrotto et al.   JAMA Neurology

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

(2016) C. Rutherford et al.   Science Signaling

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Targeting metabolism for lupus therapy

(2015) Manan M. Mehta et al.   Science Translational Medicine

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Dysregulated Cytokine Production by Dendritic Cells Modulates B Cell Responses in the NZM2410 Mouse Model of Lupus

(2014) Allison Sang et al.   PLoS One

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK

(2014) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle

(2013) S. M. Hadad et al.   Clinical & Translational Oncology

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

Myeloid Dendritic Cells from B6.NZM Sle1/Sle2/Sle3 Lupus-Prone Mice Express an IFN Signature That Precedes Disease Onset

(2012) U. Sriram et al.   JOURNAL OF IMMUNOLOGY

Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription

(2011) Fu-Yu Chueh et al.   CELLULAR SIGNALLING

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses

(2010) Amit Golding et al.   IMMUNOLOGY

Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin

(2009) Manuel Romero-Gómez et al.   HEPATOLOGY

Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus

(2009) M Petri et al.   LUPUS

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE