Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
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Title
Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
Authors
Keywords
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Journal
ONCOGENE
Volume 32, Issue 12, Pages 1475-1487
Publisher
Springer Nature
Online
2012-06-05
DOI
10.1038/onc.2012.181
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Note: Only part of the references are listed.- TP53 and MTOR crosstalk to regulate cellular senescence
- (2016) Lorenzo Galluzzi et al. Aging-US
- Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo
- (2015) Ramandeep Rattan et al. NEOPLASIA
- Use of Antidiabetic Agents and the Risk of Pancreatic Cancer: A Case–Control Analysis
- (2012) Michael Bodmer et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
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- (2012) C R Garrett et al. BRITISH JOURNAL OF CANCER
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Use of Metformin Is Not Associated with a Decreased Risk of Colorectal Cancer: A Case-Control Analysis
- (2012) M. Bodmer et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Energy transfer in "parasitic" cancer metabolism
- (2012) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Effect of Different Doses of Metformin on Serum Testosterone and Insulin in Non-Diabetic Women With Breast Cancer: A Randomized Study
- (2012) Carlo Campagnoli et al. Clinical Breast Cancer
- Mortality After Incident Cancer in People With and Without Type 2 Diabetes: Impact of metformin on survival
- (2012) C. J. Currie et al. DIABETES CARE
- Amino Acid Signaling in TOR Activation
- (2011) Joungmok Kim et al. Annual Review of Biochemistry
- Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals
- (2011) Meei-Shyuan Lee et al. BMC CANCER
- Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
- (2011) Sirwan Hadad et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin and Incident Breast Cancer among Diabetic Women: A Population-Based Case-Control Study in Denmark
- (2011) J. L. F. Bosco et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Abstract PD03-06: Clinical and Biologic Effects of Metformin in Early Stage Breast Cancer
- (2011) S Niraula et al. CANCER RESEARCH
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
- (2011) D. Iliopoulos et al. CANCER RESEARCH
- Metformin slows down aging and extends life span of female SHR mice
- (2011) Vladimir N. Anisimov et al. CELL CYCLE
- Metformin, diet and breast cancer: An avenue for chemoprevention
- (2011) Paola Muti et al. CELL CYCLE
- The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
- (2011) Alejandro Vazquez-Martin et al. CELL CYCLE
- Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
- (2011) Irina N. Alimova et al. CELL CYCLE
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Metformin induces unique biological and molecular responses in triple negative breast cancer cells
- (2011) Bolin Liu et al. CELL CYCLE
- Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response
- (2011) Alejandro Vazquez-Martin et al. CELL CYCLE
- Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a
- (2011) Cristina Oliveras-Ferraros et al. CELL CYCLE
- Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ
- (2011) Diana Whitaker-Menezes et al. CELL CYCLE
- Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer
- (2011) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions
- (2011) Alejandro Vazquez-Martin et al. DRUG RESISTANCE UPDATES
- Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
- (2011) Flavie Strappazzon et al. EMBO JOURNAL
- Metformin and cancer: new applications for an old drug
- (2011) Taxiarchis V. Kourelis et al. MEDICAL ONCOLOGY
- Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells
- (2011) Y. Zhuang et al. MOLECULAR CANCER RESEARCH
- Structure of mammalian AMPK and its regulation by ADP
- (2011) Bing Xiao et al. NATURE
- AMP-activated protein kinase: nature's energy sensor
- (2011) David Carling et al. Nature Chemical Biology
- New mTOR Targets Grb Attention
- (2011) S. S. Yea et al. SCIENCE
- AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
- (2011) J. S. Oakhill et al. SCIENCE
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
- (2011) M. Narita et al. SCIENCE
- Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives
- (2010) Darren L. Roberts et al. Annual Review of Medicine
- The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
- (2010) A. S. Green et al. BLOOD
- Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- (2010) Mahvash Zakikhani et al. BREAST CANCER RESEARCH AND TREATMENT
- Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents
- (2010) Pamela J. Goodwin et al. BREAST CANCER RESEARCH AND TREATMENT
- The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
- (2010) Alejandro Vazquez-Martin et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
- (2010) A. DeCensi et al. Cancer Prevention Research
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- (2010) R. M. Memmott et al. Cancer Prevention Research
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- (2010) K. Hosono et al. Cancer Prevention Research
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- (2010) I. Ben Sahra et al. CANCER RESEARCH
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- (2010) Yasemin Sancak et al. CELL
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- (2010) Maria Chiara Maiuri et al. CELL CYCLE
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- (2010) Fulvio Chiacchiera et al. CELL CYCLE
- Weak p53 permits senescence during cell cycle arrest
- (2010) Olga V. Leontieva et al. CELL CYCLE
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- (2010) Alejandro Vazquez-Martin et al. CELL CYCLE
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- (2010) Begoña Martin-Castillo et al. CELL CYCLE
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- (2010) A. Vazquez-Martin et al. CURRENT MOLECULAR MEDICINE
- Autophagy regulation by p53
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- Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients
- (2010) M. Monami et al. DIABETES CARE
- Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
- (2010) M. Bodmer et al. DIABETES CARE
- Diabetes and Cancer: A consensus report
- (2010) E. Giovannucci et al. DIABETES CARE
- Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials
- (2010) P. D. Home et al. DIABETOLOGIA
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- (2010) S. L. Bowker et al. DIABETOLOGIA
- Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
- (2010) Carolyn Algire et al. ENDOCRINE-RELATED CANCER
- A phase I study of temsirolimus and metformin in advanced solid tumours
- (2010) Mary J. MacKenzie et al. INVESTIGATIONAL NEW DRUGS
- Abiraterone Acetate Is Well Tolerated Without Concomitant Use of Corticosteroids
- (2010) Gerhardt Attard et al. JOURNAL OF CLINICAL ONCOLOGY
- Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase
- (2010) Kunihiro Hosono et al. MOLECULAR CARCINOGENESIS
- AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation
- (2010) Junyu Ning et al. MOLECULAR ENDOCRINOLOGY
- Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
- (2010) Kaixin Zhou et al. NATURE GENETICS
- Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
- (2010) C Algire et al. ONCOGENE
- The Association of AMPK with ULK1 Regulates Autophagy
- (2010) Jong Woo Lee et al. PLoS One
- Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
- (2010) D. Bungard et al. SCIENCE
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Obesity and Cancer Risk: Recent Review and Evidence
- (2010) Karen Basen-Engquist et al. Current Oncology Reports
- Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology
- (2009) B. Martin-Castillo et al. ANNALS OF ONCOLOGY
- Bcl2 family proteins in carcinogenesis and the treatment of cancer
- (2009) Anna Frenzel et al. APOPTOSIS
- Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
- (2009) Einat Zalckvar et al. Autophagy
- Is it Time to Test Metformin in Breast Cancer Clinical Trials?
- (2009) M. Cazzaniga et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation
- (2009) S. Saito et al. CANCER RESEARCH
- Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
- (2009) H. A. Hirsch et al. CANCER RESEARCH
- Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth
- (2009) K. Kisfalvi et al. CANCER RESEARCH
- The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
- (2009) M V Tzvetkov et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes
- (2009) G. Libby et al. DIABETES CARE
- Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16
- (2009) G. W.D. Landman et al. DIABETES CARE
- The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
- (2009) C. J. Currie et al. DIABETOLOGIA
- DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
- (2009) Einat Zalckvar et al. EMBO REPORTS
- Diabetes and cancer
- (2009) Paolo Vigneri et al. ENDOCRINE-RELATED CANCER
- Antidiabetic Therapies Affect Risk of Pancreatic Cancer
- (2009) Donghui Li et al. GASTROENTEROLOGY
- Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
- (2009) Leigh A. Cantrell et al. GYNECOLOGIC ONCOLOGY
- If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials
- (2009) Alejandro Vazquez-Martin et al. JOURNAL OF CLINICAL ONCOLOGY
- Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer
- (2009) Sao Jiralerspong et al. JOURNAL OF CLINICAL ONCOLOGY
- Conditional deletion of theLkb1gene in the mouse mammary gland induces tumour formation
- (2009) Afshan McCarthy et al. JOURNAL OF PATHOLOGY
- LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism
- (2009) Marnix Jansen et al. PHYSIOLOGICAL REVIEWS
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- (2009) R. J. Colman et al. SCIENCE
- Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
- (2009) E. Zeqiraj et al. SCIENCE
- Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease
- (2009) Valter Donadon et al. WORLD JOURNAL OF GASTROENTEROLOGY
- p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal Compartment
- (2009) Z. Feng Cold Spring Harbor Perspectives in Biology
- ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
- (2009) Elton Zeqiraj et al. PLOS BIOLOGY
- Sulphonylureas and cancer: a case–control study
- (2008) Matteo Monami et al. ACTA DIABETOLOGICA
- Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
- (2008) Kathryn N. Phoenix et al. BREAST CANCER RESEARCH AND TREATMENT
- The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase
- (2008) M. Zakikhani et al. Cancer Prevention Research
- Metformin suppresses intestinal polyp growth in ApcMin/+ mice
- (2008) Ayako Tomimoto et al. CANCER SCIENCE
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- Insulin-Lowering Effects of Metformin in Women with Early Breast Cancer
- (2008) Pamela J. Goodwin et al. Clinical Breast Cancer
- Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth
- (2008) C. Algire et al. ENDOCRINE-RELATED CANCER
- In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
- (2008) Walter H. Gotlieb et al. GYNECOLOGIC ONCOLOGY
- Long-term All-Cause Mortality in Cancer Patients With Preexisting Diabetes Mellitus
- (2008) Bethany B. Barone JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy
- (2008) Madhuri Kakarala et al. JOURNAL OF CLINICAL ONCOLOGY
- Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
- (2008) X. Li et al. JNCI-Journal of the National Cancer Institute
- Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
- (2008) Andrew G Renehan et al. LANCET
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
- (2008) I Ben Sahra et al. ONCOGENE
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
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