Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

FK506 Reduces Amyloid Plaque Burden and Induces MMP-9 in AβPP/PS1 Double Transgenic Mice

(2017) Hyun-Seok Hong et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes

(2015) Allen C. T. Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer’s disease

(2014) J Byun et al.   CELL DEATH AND DIFFERENTIATION

RS11212617 is associated with metformin treatment response in type 2 diabetes in Shanghai local Chinese population

(2014) Y. Zhou et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease

(2012) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling

(2011) Sung Min Son et al.   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer’s disease animal model

(2009) H. J. Cho et al.   FASEB JOURNAL

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

(2008) Chengyong Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY