The Therapeutic Potential of Metformin in Neurodegenerative Diseases
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Therapeutic Potential of Metformin in Neurodegenerative Diseases
Authors
Keywords
-
Journal
Frontiers in Endocrinology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-07-19
DOI
10.3389/fendo.2018.00400
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The genetics of Parkinson disease
- (2018) Hao Deng et al. AGEING RESEARCH REVIEWS
- No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
- (2018) Johannes J Gaare et al. BRAIN
- Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
- (2018) Julia C Fitzgerald et al. BRAIN
- Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
- (2018) Thomas G. McWilliams et al. Cell Metabolism
- Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin
- (2018) Juliette J. Lee et al. JOURNAL OF CELL BIOLOGY
- 2017 FDA drug approvals
- (2018) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
- (2018) Diego Grassi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A reappraisal on metformin
- (2018) Tuğba Adak et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
- (2018) Yongsung Kim et al. Cell Reports
- Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function
- (2018) Ana Agustí et al. Frontiers in Neuroscience
- Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin
- (2018) Chih-Cheng Hsu et al. JOURNAL OF ALZHEIMERS DISEASE
- High Prevalence of Diabetes Mellitus in a Five-Generation Chinese Family with Huntington's Disease
- (2018) Yueqing Hu et al. JOURNAL OF ALZHEIMERS DISEASE
- Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes
- (2018) Tze Pin Ng et al. JOURNAL OF ALZHEIMERS DISEASE
- The role of pre-morbid diabetes on developing amyotrophic lateral sclerosis
- (2017) F. D'Ovidio et al. EUROPEAN JOURNAL OF NEUROLOGY
- Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway
- (2017) Leitao Wu et al. Evidence-based Complementary and Alternative Medicine
- Diabetes is Not Associated with Alzheimer’s Disease Neuropathology
- (2017) Maria Niures Pimentel dos Santos Matioli et al. JOURNAL OF ALZHEIMERS DISEASE
- Brain gray matter changes in type 2 diabetes mellitus: A meta-analysis of whole-brain voxel-based morphometry study
- (2017) Guangyao Wu et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Differential effects of metformin on age related comorbidities in older men with type 2 diabetes
- (2017) Chen-Pin Wang et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
- (2017) Sylvia Torres-Odio et al. Journal of Neuroinflammation
- Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson's disease
- (2017) Marissa Ong et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
- (2017) Koji Abe et al. LANCET NEUROLOGY
- Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
- (2017) Valery L Feigin et al. LANCET NEUROLOGY
- Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
- (2017) Anastasia G. Efthymiou et al. Molecular Neurodegeneration
- Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity
- (2017) Wojciech Bobela et al. Molecular Neurodegeneration
- Glitazone use associated with reduced risk of Parkinson's disease
- (2017) Brage Brakedal et al. MOVEMENT DISORDERS
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
- (2017) Kuan-lin Huang et al. NATURE NEUROSCIENCE
- Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes
- (2017) Ariela R. Orkaby et al. NEUROLOGY
- Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease
- (2017) Nikita Katila et al. NEUROPHARMACOLOGY
- Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus
- (2017) Yi-Chun Kuan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease
- (2017) Yunlong Zhang et al. Cell Death & Disease
- Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
- (2017) Hojin Kang et al. Oncotarget
- Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice
- (2017) Nopporn Thangthaeng et al. Aging and Disease
- Innate Immune Function of Mitochondrial Metabolism
- (2017) David Sancho et al. Frontiers in Immunology
- The Alzheimer's Disease Mitochondrial Cascade Hypothesis
- (2017) Russell H. Swerdlow et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin intake associates with better cognitive function in patients with Huntington's disease
- (2017) David Hervás et al. PLoS One
- Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology
- (2016) Erin L. Abner et al. Alzheimers & Dementia
- Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels
- (2016) Henry H. Ruiz et al. Alzheimers & Dementia
- Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice
- (2016) Joanne S. Allard et al. BEHAVIOURAL BRAIN RESEARCH
- PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways
- (2016) Xiaomin Cang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
- (2016) Evanna L. Mills et al. CELL
- Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer
- (2016) D S Matassa et al. CELL DEATH AND DIFFERENTIATION
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance
- (2016) Amy R. Cameron et al. CIRCULATION RESEARCH
- Glucose Metabolism: A Sweet Relief of Alzheimer’s Disease
- (2016) Claudia Duran-Aniotz et al. CURRENT BIOLOGY
- Impact of Insulin Sensitizers on the Incidence of Dementia: A Meta-Analysis
- (2016) Fang Ye et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction
- (2016) Ming-Chang Chiang et al. EXPERIMENTAL CELL RESEARCH
- Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance
- (2016) Ming Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Vascular Risk Factors and Cognition in Parkinson’s Disease
- (2016) Andrea Pilotto et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
- (2016) José A. Luchsinger et al. JOURNAL OF ALZHEIMERS DISEASE
- Traumatic brain injury and age at onset of cognitive impairment in older adults
- (2016) Wei Li et al. JOURNAL OF NEUROLOGY
- Risk of Parkinson Disease in Diabetes Mellitus
- (2016) Xuejing Yue et al. MEDICINE
- Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
- (2016) Erica Barini et al. Molecular Neurodegeneration
- Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease
- (2016) Naveed Malek et al. MOVEMENT DISORDERS
- Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes
- (2016) Paul K. Crane et al. NEUROBIOLOGY OF AGING
- Antidiabetic drugs restore abnormal transport of amyloid-β across the blood–brain barrier and memory impairment in db / db mice
- (2016) Fang Chen et al. NEUROPHARMACOLOGY
- Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration
- (2016) Pier Francesca Porceddu et al. NEUROTOXICITY RESEARCH
- Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system
- (2016) Afrah A.K. Ismaiel et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
- (2016) Christian Dölle et al. Nature Communications
- Environmental risk factors for dementia: a systematic review
- (2016) Lewis O. J. Killin et al. BMC Geriatrics
- Antecedent Disease and Amyotrophic Lateral Sclerosis: What Is Protecting Whom?
- (2016) Sabrina K. Hollinger et al. Frontiers in Neurology
- Meta-analysis of risk factors for Parkinson’s disease dementia
- (2016) Yaqian Xu et al. Translational Neurodegeneration
- Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
- (2016) Jacqueline A. Bayliss et al. PLoS One
- Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective
- (2015) Matthew Baumgart et al. Alzheimers & Dementia
- Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
- (2015) Claudia Cooper et al. AMERICAN JOURNAL OF PSYCHIATRY
- Effect of pioglitazone medication on the incidence of dementia
- (2015) Michael T. Heneka et al. ANNALS OF NEUROLOGY
- Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect
- (2015) Pasquale Picone et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues
- (2015) Ekaterina G. Kochkina et al. BIOGERONTOLOGY
- Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes
- (2015) Calum D. Moulton et al. Brain Imaging and Behavior
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1
- (2015) M. Seillier et al. EMBO Molecular Medicine
- Association between diabetes and amyotrophic lateral sclerosis in Sweden
- (2015) D. Mariosa et al. EUROPEAN JOURNAL OF NEUROLOGY
- Risk of Amyotrophic Lateral Sclerosis in Patients With Diabetes: A Nationwide Population-Based Cohort Study
- (2015) Yu Sun et al. JOURNAL OF EPIDEMIOLOGY
- Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
- (2015) A. Siddiqui et al. JOURNAL OF NEUROSCIENCE
- Lewy body dementias
- (2015) Zuzana Walker et al. LANCET
- Mitochondrial regulation of β-cell function: Maintaining the momentum for insulin release
- (2015) Brett A. Kaufman et al. MOLECULAR ASPECTS OF MEDICINE
- Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis
- (2015) Sabrina Paganoni et al. MUSCLE & NERVE
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- The role of type 2 diabetes in neurodegeneration
- (2015) Giuseppe Verdile et al. NEUROBIOLOGY OF DISEASE
- Association between nutritional status and disease severity using the amyotrophic lateral sclerosis (ALS) functional rating scale in ALS patients
- (2015) Yongsoon Park et al. NUTRITION
- Executive Function in Adults With Type 2 Diabetes
- (2015) Corita Vincent et al. PSYCHOSOMATIC MEDICINE
- Diabetes Mellitus, Obesity, and Diagnosis of Amyotrophic Lateral Sclerosis
- (2015) Marianthi-Anna Kioumourtzoglou et al. JAMA Neurology
- PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury
- (2015) Weiwei Wu et al. PLoS One
- A Meta-Analysis of Cognitive Functioning in Nondemented Adults with Type 2 Diabetes Mellitus
- (2014) Michelle C.E. Monette et al. Canadian Journal of Diabetes
- Diabetes Mellitus and Dementia
- (2014) Toshiharu Ninomiya Current Diabetes Reports
- Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues
- (2014) Gilbert Richarme et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease
- (2014) Shitao Wang et al. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
- Pathways to Alzheimer's disease
- (2014) J. Hardy et al. JOURNAL OF INTERNAL MEDICINE
- Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice
- (2014) Carola Rotermund et al. JOURNAL OF NEUROCHEMISTRY
- Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature
- (2014) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Magnitude of Cognitive Dysfunction in Adults with Type 2 Diabetes: A Meta-analysis of Six Cognitive Domains and the Most Frequently Reported Neuropsychological Tests Within Domains
- (2014) Priya Palta et al. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
- Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis
- (2014) Chin Cheng et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial
- (2014) Anne-Marie Wills et al. LANCET
- Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
- (2014) Sam Norton et al. LANCET NEUROLOGY
- Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes
- (2014) Joungil Choi et al. MITOCHONDRION
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- The ongoing pursuit of neuroprotective therapies in Parkinson disease
- (2014) Dilan Athauda et al. Nature Reviews Neurology
- Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice
- (2014) Rachael Lennox et al. NEUROPHARMACOLOGY
- Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice
- (2014) S.P. Patil et al. NEUROSCIENCE
- Statins in neurological disorders: An overview and update
- (2014) Anna Maria Malfitano et al. PHARMACOLOGICAL RESEARCH
- Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies
- (2014) Lin Lu et al. PLoS One
- Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study
- (2014) Chin-Chou Huang et al. PLoS One
- Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity
- (2014) Shih-Lung Woo et al. PLoS One
- The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex
- (2014) Moritz M. Hettich et al. PLoS One
- PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
- (2014) V. A. Morais et al. SCIENCE
- A Systematic Assessment of Mitochondrial Function Identified Novel Signatures for Drug-Induced Mitochondrial Disruption in Cells
- (2014) Nianyu Li et al. TOXICOLOGICAL SCIENCES
- Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
- (2014) Andrea Rasola et al. TRENDS IN CELL BIOLOGY
- Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation
- (2014) B I Pérez-Revuelta et al. Cell Death & Disease
- Prevalence of mixed pathologies in the aging brain
- (2014) Jasmin Rahimi et al. Alzheimers Research & Therapy
- PINK1 deficiency in -cells increases basal insulin secretion and improves glucose tolerance in mice
- (2014) E. Deas et al. Open Biology
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
- (2013) Antonella Caccamo et al. AGING CELL
- Individuals with Alzheimer's disease exhibit a high prevalence of undiagnosed impaired glucose tolerance and type 2 diabetes mellitus
- (2013) Raymond Turner et al. Alzheimers & Dementia
- Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
- (2013) Emelie Karnevi et al. BMC CANCER
- Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson’s disease
- (2013) Heather Mortiboys et al. BRAIN
- Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
- (2013) V. Nair et al. CARCINOGENESIS
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
- (2013) Marco Sciacovelli et al. Cell Metabolism
- Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship
- (2013) N. T. Vagelatos et al. EPIDEMIOLOGIC REVIEWS
- Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
- (2013) Ling Wang et al. EXPERIMENTAL NEUROLOGY
- Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity
- (2013) Benny Björkblom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy
- (2013) Chong Wang et al. MOLECULAR NEUROBIOLOGY
- Mitonuclear protein imbalance as a conserved longevity mechanism
- (2013) Riekelt H. Houtkooper et al. NATURE
- Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease
- (2013) Laura Dunn et al. NEUROBIOLOGY OF AGING
- The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
- (2013) Marija Dulovic et al. NEUROBIOLOGY OF DISEASE
- The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation
- (2013) Georges Mairet-Coello et al. NEURON
- Glucose Levels and Risk of Dementia
- (2013) Paul K. Crane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners
- (2013) Rive Sarfstein et al. PLoS One
- Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
- (2013) S. Yoshida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin: an old but still the best treatment for type 2 diabetes
- (2013) Lilian Beatriz Aguayo Rojas et al. Diabetology & Metabolic Syndrome
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Diabetes drugs and neurological disorders: new views and therapeutic possibilities
- (2013) Cesare Patrone et al. Lancet Diabetes & Endocrinology
- Increased Aβ production prompts the onset of glucose intolerance and insulin resistance
- (2012) Margarita Jiménez-Palomares et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”
- (2012) George G. Glenner BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
- (2012) Isidro Salcedo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
- (2012) Isabel Garcia-Cao et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- The PI3K/AKT/mTOR Pathway as a Therapeutic Target in Endometrial Cancer
- (2012) B. M. Slomovitz et al. CLINICAL CANCER RESEARCH
- Amyloid- Induces Hepatic Insulin Resistance In Vivo via JAK2
- (2012) Y. Zhang et al. DIABETES
- A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin
- (2012) A. D. McNeilly et al. DIABETOLOGIA
- Human DJ-1 and its homologs are novel glyoxalases
- (2012) Ju-young Lee et al. HUMAN MOLECULAR GENETICS
- Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
- (2012) G. Cheng et al. INTERNAL MEDICINE JOURNAL
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- AMP-Activated Protein Kinase Restricts IFN- Signaling
- (2012) G. P. Meares et al. JOURNAL OF IMMUNOLOGY
- Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
- (2012) X. Julia Xu et al. JOURNAL OF LIPID RESEARCH
- AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease
- (2012) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study
- (2012) Patrick Imfeld et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Dementia is associated with Insulin Resistance in patients with Parkinson's Disease
- (2012) Domenico Bosco et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats
- (2012) Hiranya Pintana et al. LIFE SCIENCES
- Oligodendroglia metabolically support axons and contribute to neurodegeneration
- (2012) Youngjin Lee et al. NATURE
- Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
- (2012) Ursula Fünfschilling et al. NATURE
- Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites
- (2012) Peizhou Jiang et al. NEUROBIOLOGY OF AGING
- Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort
- (2012) Mark L. Wahlqvist et al. PARKINSONISM & RELATED DISORDERS
- Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
- (2012) Jiejie Li et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis
- (2012) Luc Dupuis et al. PLoS One
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
- (2012) Erin K. Butler et al. PLoS Genetics
- AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
- (2011) Claire Thornton et al. BIOCHEMICAL JOURNAL
- Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons
- (2011) Marcus J. Calkins et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- Cellular and molecular mechanisms of metformin: an overview
- (2011) Benoit Viollet et al. CLINICAL SCIENCE
- mTOR signaling in disease
- (2011) Eva Dazert et al. CURRENT OPINION IN CELL BIOLOGY
- Diabetes and Risk of Parkinson's Disease: A systematic review and meta-analysis
- (2011) E. Cereda et al. DIABETES CARE
- Diabetes and the Risk of Developing Parkinson's Disease in Denmark
- (2011) E. Schernhammer et al. DIABETES CARE
- Diabetes and Risk of Parkinson's Disease
- (2011) Q. Xu et al. DIABETES CARE
- Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein
- (2011) N. Mody et al. DIABETOLOGIA
- Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
- (2011) X. Stephenne et al. DIABETOLOGIA
- Insulin resistance impairs nigrostriatal dopamine function
- (2011) J.K. Morris et al. EXPERIMENTAL NEUROLOGY
- Signal transduction by reactive oxygen species
- (2011) Toren Finkel JOURNAL OF CELL BIOLOGY
- Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease
- (2011) Xiulian Sun et al. JOURNAL OF NEUROCHEMISTRY
- Etiology and pathogenesis of Parkinson's disease
- (2011) Anthony H. Schapira et al. MOVEMENT DISORDERS
- Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes
- (2011) Amit Gupta et al. NEUROPHARMACOLOGY
- Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice
- (2011) Hannah M. Kaneb et al. PLoS One
- Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet
- (2010) Jill K. Morris et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes
- (2010) Laura D. Baker et al. ARCHIVES OF NEUROLOGY
- Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- (2010) Mahvash Zakikhani et al. BREAST CANCER RESEARCH AND TREATMENT
- Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis
- (2010) R. M. Memmott et al. Cancer Prevention Research
- Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
- (2010) Adem Kalender et al. Cell Metabolism
- Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials
- (2010) C. Lamanna et al. DIABETES OBESITY & METABOLISM
- Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
- (2010) A. Maida et al. DIABETOLOGIA
- ALS disease onset may occur later in patients with pre-morbid diabetes mellitus
- (2010) A. Jawaid et al. EUROPEAN JOURNAL OF NEUROLOGY
- IGF-I and the aging mammalian brain
- (2010) J. Piriz et al. EXPERIMENTAL GERONTOLOGY
- AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
- (2010) Valérie Vingtdeux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insulin Promotes Survival of Amyloid-Beta Oligomers Neuroblastoma Damaged Cells via Caspase 9 Inhibition and Hsp70 Upregulation
- (2010) M. Di Carlo et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Case–control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan
- (2010) Yoshihiro Miyake et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
- (2010) Calvin K. Yip et al. MOLECULAR CELL
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
- Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels
- (2010) Christiane Reitz et al. NEUROBIOLOGY OF AGING
- Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
- (2010) Ewan C. McNay et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study
- (2010) S. Ahtiluoto et al. NEUROLOGY
- Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study
- (2010) T. Matsuzaki et al. NEUROLOGY
- Regulation of Tau Pathology by the Microglial Fractalkine Receptor
- (2010) Kiran Bhaskar et al. NEURON
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A deposition in an Alzheimer mouse model with diabetes
- (2010) S. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1
- (2010) Keith A. Vossel et al. SCIENCE
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
- (2009) Steven J. Greco et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- (2009) Jae-Sun Choi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mitochondrial dysfunction in Parkinson's disease
- (2009) Konstanze F. Winklhofer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders
- (2009) Louis A. Profenno et al. BIOLOGICAL PSYCHIATRY
- DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
- (2009) Philipp J. Kahle et al. FREE RADICAL BIOLOGY AND MEDICINE
- Huntington’s Disease Does Not Appear to Increase the Risk of Diabetes Mellitus
- (2009) T. W. Boesgaard et al. JOURNAL OF NEUROENDOCRINOLOGY
- RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation
- (2009) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Robust Pacemaking in Substantia Nigra Dopaminergic Neurons
- (2009) J. N. Guzman et al. JOURNAL OF NEUROSCIENCE
- The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1
- (2009) Angel Herrero-Mendez et al. NATURE CELL BIOLOGY
- Akt signal transduction dysfunction in Parkinson's disease
- (2009) Suzanne Timmons et al. NEUROSCIENCE LETTERS
- Diabetes preceding Parkinson's disease onset. A case–control study
- (2009) Marco D'Amelio et al. PARKINSONISM & RELATED DISORDERS
- Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis
- (2009) Feng-Ping Lu et al. PLoS One
- Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
- (2009) Suzana Gispert et al. PLoS One
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
- (2009) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- (2009) V. Rhein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
- (2009) E. Santini et al. Science Signaling
- Glucose Homeostasis in Huntington Disease
- (2008) Nebojša M. Lalić et al. ARCHIVES OF NEUROLOGY
- Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
- (2008) Xiumei Zuo et al. BRAIN RESEARCH
- Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications
- (2008) Karen Neumann et al. Current Alzheimer Research
- Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease
- (2008) J. A. Driver et al. DIABETES CARE
- Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
- (2008) J. Simon-Sanchez et al. HUMAN MOLECULAR GENETICS
- Parkinson's disease: clinical features and diagnosis
- (2008) J Jankovic JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The Role of PI3/Akt Pathway in the Protective Effect of Insulin against Corticosterone Cell Death Induction in Hippocampal Cell Culture
- (2008) Maryam Moosavi et al. NEUROENDOCRINOLOGY
- RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
- (2008) M. P. van der Brug et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search