Article
Medicine, Research & Experimental
Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Johanna C. Arroyave Ospina, Yana Geng, Juan M. Soto, Jose A. Rodrigo, Tatiana Alieva, Manon Buist-Homan, Frank Lezoualc'h, Xiaodong Cheng, Martina Schmidt, Han Moshage
Summary: The study demonstrates that metformin protects against diclofenac (DF)-induced apoptosis in hepatocytes, with this protective effect being dependent on EPAC-2. Metformin is able to reverse the mitochondrial dysfunction induced by DF.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xuehua Li, Jacob Kordsmeier, Intawat Nookaew, Ha-Neui Kim, Jinhu Xiong
Summary: In this study, the researchers found that the mechanically sensitive ion channel Piezo1 plays a critical role in mitochondrial adaptation to mechanical stimulation. They also discovered that cAMP signaling contributes to the increase in mitochondrial oxidative phosphorylation (OXPHOS) induced by activation of Piezo1.
Article
Endocrinology & Metabolism
Sukanya Guhathakurta, Niyazi Umut Erdogdu, Juliane J. Hoffmann, Iga Grzadzielewska, Alexander Schendzielorz, Janine Seyfferth, Christoph U. Martensson, Mauro Corrado, Adam Karoutas, Bettina Warscheid, Nikolaus Pfanner, Thomas Becker, Asifa Akhtar
Summary: This study reveals the important role of MYST family lysine acetyltransferase MOF in energy metabolism through mitochondrial protein acetylation. Loss of MOF-KANSL complex members leads to mitochondrial defects, and COX17 is identified as a target of MOF acetylation. Acetylation-mimetic COX17 can rescue mitochondrial defects, suggesting an activatory role of mitochondrial protein acetylation in the electron transport chain. The findings from patients with MOF syndrome also support these conclusions.
Article
Chemistry, Multidisciplinary
Ning Sheng, Zhihui Zhang, Hao Zheng, Congyu Ma, Menglin Li, Zhe Wang, Lulu Wang, Jiandong Jiang, Jinlan Zhang
Summary: This study discovered a molecule called scutellarin (SG) that can treat neurodegenerative diseases by regulating energy metabolism and repairing mitochondrial damage. The molecule was found to protect mitochondria through the PDK-PDC axis and mitochondrial glucose oxidation.
Article
Immunology
Ying Su, Shan Lu, Chenjian Hou, Kehan Ren, Meili Wang, Xiaoli Liu, Shanyu Zhao, Xiuping Liu
Summary: This study demonstrates that metformin has significant therapeutic value in NASH-derived liver fibrosis by inducing apoptosis in HSCs, but does not affect the proliferation of hepatocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Ping He, Fengyi Liu, Mingzheng Li, Mingxing Ren, Xu Wang, Yangjia Deng, Xianghao Wu, Yuzhou Li, Sheng Yang, Jinlin Song
Summary: This study demonstrates that the persistent opening of mPTPs triggered by mitoCa(2+) overload can be effectively controlled by mitochondrial-targeted nanogluttons. These nanogluttons significantly inhibit the inflammatory activation of macrophages and alleviate periodontal inflammation in mice, leading to reduced osteoclast activity and bone loss.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Simmi Anjum, Swati Srivastava, Lalita Panigrahi, Uzair Ahmad Ansari, Arun Kumar Trivedi, Shakil Ahmed
Summary: The study reveals the important role of Wat1 in regulating mitochondrial biogenesis and cellular homeostasis. The loss of Wat1 causes respiratory defects and mitochondrial depolarization, leading to a decrease in ATP production. Wat1 is involved in mitochondrial fission, autophagy, and the maintenance of calcium ion homeostasis. The study also shows the TORC1-dependent involvement of Wat1 in maintaining mitochondrial integrity and the crosstalk between mitochondria and the endoplasmic reticulum.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Geriatrics & Gerontology
Allen Herbst, Austin Hoang, Chiye Kim, Judd M. Aiken, Debbie McKenzie, Deena S. Goldwater, Jonathan Wanagat
Summary: Testing the hypothesis that metformin treatment would be toxic to older rats, two doses of metformin were evaluated in 30-month-old rats for 4 months. Results showed that metformin did not compromise mtDNA integrity, did not affect mortality, and may have potential cardiac benefits at appropriate doses.
REJUVENATION RESEARCH
(2021)
Article
Neurosciences
Karlis A. Justs, Zhongmin Lu, Amit K. Chouhan, Jolanta A. Borycz, Zhiyuan Lu, Ian A. Meinertzhagen, Gregory T. Macleod
Summary: Neurons require stable energy supply and optimize mitochondrial volume and density according to presynaptic power demands.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman
Summary: Zinc plays essential roles in cellular functions in the brain, but can also induce harmful cascades in neurons, particularly targeting mitochondria. Understanding the mechanisms of zinc-induced mitochondrial defects in neurotoxicity and neurodegeneration may present novel therapeutic targets in clinical settings.
Article
Biochemistry & Molecular Biology
Zhangjin Shen, Lingkai Gu, Yuwan Liu, Lingfang Wang, Jiawei Zhu, Sangsang Tang, Xinyi Wei, Jiaying Wang, Songfa Zhang, Xinyu Wang, Xiaodong Cheng, Xing Xie, Weiguo Lu
Summary: PLAA plays an important role in ovarian cancer metastasis and its inhibition is associated with poorer prognosis and high-risk clinicopathological features. PLAA inhibits ovarian cancer metastasis by suppressing TRPC3-mediated intracellular Ca2+ level. Moreover, PLAA stabilizes TRPC3 mRNA expression by inhibiting METTL3 expression.
Article
Cell & Tissue Engineering
Qin Zhou, Min Xie, Jing Zhu, Qin Yi, Bin Tan, Yasha Li, Liang Ye, Xinyuan Zhang, Ying Zhang, Jie Tian, Hao Xu
Summary: This study elucidated the mechanism of sepsis-induced myocardial injury, revealing the crucial role of PINK1 in mitochondrial calcium efflux in cardiomyocytes. It was found that exosomes isolated from huMSCs carried Pink1 mRNA, which could enhance PINK1 expression and protect cardiomyocytes from sepsis-induced injury by reversing mitochondrial calcium efflux disorder. The PINK1-PKA-NCLX axis was confirmed to play an important role in maintaining mitochondrial calcium homeostasis during sepsis, suggesting PINK1 as a potential therapeutic target for sepsis-induced heart dysfunction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Environmental
Muhammad Saqib Nawaz, Talal Alamoudi, Sofiane Soukane, M. Obaid, Noreddine Ghaffour
Summary: Water and energy are crucial factors in assessing the feasibility of water treatment techniques. This study investigated the impact of maintaining or not maintaining the colder stream temperature on water flux, reverse solute flux, and energy consumption in industrial forward osmosis applications. The results showed that not maintaining the colder stream temperature led to increased water flux, reverse solute flux, and reduced energy consumption.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung
Summary: Researchers found that TSLP can regulate ROS production and mitophagy through AMPK activation and histone modification, thus affecting the expression of M1/M2 chemokines in human monocytes.
CELL AND BIOSCIENCE
(2022)
Article
Engineering, Environmental
Dasol Choi, Soyoung Noh, Youngjune Park
Summary: Calcium looping (CaL)-based solar to thermochemical energy storage is a promising option for long-term thermal energy storage in concentrated solar power generation. In this study, multi-doping of transition metals and CaCl2 was investigated to enhance the optical absorption and carbonation reactivity of synthetic CaO-based materials. The proposed materials exhibited significantly enhanced optical absorption and maintained high performance throughout multiple cycles of CaL reactions. The reaction mechanism was studied, and a salt-promoted carbonation mechanism was proposed to improve the mass transfer of Ca2+O2- to adsorbed CO2. Based on the findings, the synergistic use of CaCl2 multi-doping method for synthetic CaO designs is suggested.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Cell Biology
Sandy Fellah, Romain Larrue, Marin Truchi, Georges Vassaux, Bernard Mari, Christelle Cauffiez, Nicolas Pottier
Summary: This article summarizes the functions of the noncoding RNA DNM3OS in diseases and its potential as a novel therapeutic target.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biochemistry & Molecular Biology
Ricardo Sanchez-Rodriguez, Caterina Tezze, Andrielly H. R. Agnellini, Roberta Angioni, Francisca C. Venegas, Chiara Cioccarelli, Fabio Munari, Nicole Bertoldi, Marcella Canton, Maria Andrea Desbats, Leonardo Salviati, Rosanna Gissi, Alessandra Castegna, Maria Eugenia Soriano, Marco Sandri, Luca Scorrano, Antonella Viola, Barbara Molon
Summary: Macrophages play essential roles in host defense against pathogens, inflammation regulation, and tissue regeneration. OPA1, a mitochondria-shaping protein, is shown to be a key metabolic driver in macrophage activation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Urology & Nephrology
Astrid Boulenger de Hauteclocque, Loic Ferrer, Damien Ambrosetti, Solene Ricard, Pierre Bigot, Karim Bensalah, Francois Henon, Nicolas Doumerc, Arnaud Mejean, Virginie Verkarre, Charles Dariane, Stephane Larre, Cecile Champy, Alexandre de La Taille, Franck Bruyere, Morgan Roupret, Philippe Paparel, Stephane Droupy, Alexis Fontenil, Jean-Jacques Patard, Xavier Durand, Thibaut Waeckel, Herve Lang, Cedric Lebacle, Laurent Guy, Geraldine Pignot, Matthieu Durand, Jean-Alexandre Long, Thomas Charles, Evanguelos Xylinas, Romain Boissier, Mokrane Yacoub, Thierry Colin, Jean-Christophe Bernhard
Summary: This study assessed the impact of pathological upstaging in renal cell carcinoma patients and evaluated the oncological safety of different surgical approaches. A machine-learning model was developed to predict upstaging. The findings showed that machine-learning technology can be useful in evaluating and predicting upstaging in renal cell carcinoma. Partial nephrectomy did not compromise oncological outcomes in incidental upstaging, even for large tumors.
Editorial Material
Oncology
Michael Cerezo, Stephane Rocchi
Article
Biochemistry & Molecular Biology
Pierre-Edouard Grillet, Elodie Desplanche, Quentin Wynands, Fares Gouzi, Patrice Bideaux, Aurelie Fort, Valerie Scheuermann, Alain Lacampagne, Anne Virsolvy, Jerome Thireau, Pieter de Tombe, Arnaud Bourdin, Olivier Cazorla
Summary: Chronic obstructive pulmonary disease (COPD) is a clinically significant condition involving airway abnormalities and pulmonary destruction. Cardiovascular disease, particularly heart failure with preserved ejection fraction (HFpEF), is a significant comorbidity of COPD. Traditional treatments have shown minimal efficacy in treating COPD-associated HFpEF, highlighting the need to identify potential mechanisms linking the two conditions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Dermatology
Hanene Bzioueche, Katia Boniface, Claire Drullion, Sandrine Marchetti, Berengere Chignon-Sicard, Laura Sormani, Stephane Rocchi, Julien Seneschal, Thierry Passeron, Meri K. Tulic
Summary: Vitiligo is an autoimmune disease characterized by melanocyte loss and white patches on the skin. This study demonstrates that house dust mite (HDM) can induce inflammatory responses and melanocyte detachment in vitiligo through protease activity. HDM may act as an external source of pathogen-associated molecular pattern molecules in vitiligo, and MMP-9 inhibitors could be potential therapeutic targets. Furthermore, studying specific vitiligo endophenotypes can help understand the environmental contribution to the disease.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Haecker, Gyorgy Hajnoczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jaeaettelae, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Munoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Nunez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Summary: Apoptosis is a regulated cell death process involving caspase family proteases. Inhibiting or delaying apoptosis experimentally through pharmacological and genetic strategies has demonstrated its importance in embryonic development, tissue homeostasis, and the pathogenesis of various human disorders. Defects in apoptotic cell death machinery impair development and promote oncogenesis, while inappropriate activation of apoptosis contributes to cell loss and tissue damage in neurological, cardiovascular, renal, hepatic, infectious, neoplastic, and inflammatory conditions.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Hanene Bzioueche, Myriam Tamelghaghet, Berengere Chignon-Sicard, Noemie Bazile, Pauline Hauchecorne, Maria Barbero Calderon, Pauline Meunier, Stephane Rocchi, Thierry Passeron, Meri K. Tulic
Summary: Ceramides are crucial for the barrier function of normal skin. Reduced ceramide levels are associated with atopic dermatitis. This study examined the impact of house dust mite (HDM) on skin integrity and the effect of different ceramides on HDM-induced skin damage. The presence of Ceramide AD (TM) in a cream inhibited HDM-induced damage and restored skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Hinault, Philippe Caroli-Bosc, Frederic Bost, Nicolas Chevalier
Summary: Diabetes mellitus is a significant global health problem, impacting individuals and economies. The chronic hyperglycemia associated with diabetes leads to severe complications, including retinopathy, kidney failure, and cardiovascular diseases. While genetic factors and environmental factors like sedentary lifestyles, overweight, and obesity contribute to the development of diabetes, there is growing evidence suggesting the role of endocrine-disrupting chemicals (EDCs) in the pathophysiology of diabetes and metabolic disorders. This narrative review critically examines the impact of EDCs on our endocrine system and their link to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ruben Quintana-Cabrera, Luca Scorrano
Summary: Mitochondria are not only central organelles in metabolism and energy conversion but also platforms for cellular signaling cascades. The shape and ultrastructure of mitochondria are dynamically regulated by mitochondria-shaping proteins, and their alterations in human diseases can be explored for drug discovery.
Article
Oncology
Olivia Vidal-Cruchez, Victoria J. Nicolini, Tifenn Rete, Karine Jacquet, Roger Rezzonico, Caroline Lacoux, Marie-Angela Domdom, Barnabe Romeo, Jeremie Roux, Arnaud Hubstenberger, Bernard Mari, Baharia Mograbi, Paul Hofman, Patrick Brest
Summary: Cancer therapies targeting the MAPK pathway lead to drug resistance. Overexpression of RAS has been linked to this resistance, but the underlying mechanisms are unclear. This study shows that MEK inhibitors increase translation of KRAS and NRAS oncogenes through liquid-liquid phase separation, specifically P-body dissolution. This feedback loop involving P-bodies and phase separation could be important for future targeted therapies.
Article
Cell Biology
Marie-Luce Vignais, Jennyfer Levoux, Pierre Sicard, Khattar Khattar, Catherine Lozza, Marianne Gervais, Safia Mezhoud, Jean Nakhle, Frederic Relaix, Onnik Agbulut, Jeremy Fauconnier, Anne-Marie Rodriguez
Summary: Preconditioning MSCs with cardiac mitochondria can enhance their therapeutic potential for ischemic heart disease.
News Item
Oncology
Martina Semenzato, Luca Scorrano
Article
Cell & Tissue Engineering
Lamia Goual, Elisa Bounasri, Marie Vincenti, Pascal Amedro, Romain Desprat, Florence Bernex, Jean-Marc Lemaitre, Jean-Luc Pasquie, Alain Lacampagne, Jerome Thireau, Albano C. Meli
Summary: This study derived iPSC lines from two patients with LQT2, providing a valuable model to study the molecular and functional impact of the hERG channel gene mutation and develop personalized therapeutic approaches for this syndrome.
STEM CELL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffre, Leah R. Sittenfeld, Jean-Luc Pasquie, Sarah Colombani, Bruce B. Lerman, Shuibing Chen, Andrew R. Marks, Jim W. Cheung, Todd Evans, Alain Lacampagne, Albano C. Meli
Summary: The study evaluated the effects of anti-arrhythmic drugs on the abnormal Ca2+ handling and contractile properties of patient-specific PMVT hiPSC-CMs. The results showed that S107 and flecainide were the most effective in preventing the abnormal Ca2+ release and contractile properties in RyR2-H29D hiPSC-CMs.
STEM CELL RESEARCH & THERAPY
(2023)