Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

(2016) Bruna Corominas-Faja et al.   Aging-US

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase

(2013) Andrew J.Y. Jones et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

(2013) James A. Birrell et al.   BIOCHEMICAL JOURNAL

Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I

(2013) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

(2013) Barbara Salani et al.   Scientific Reports

Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil

(2012) Jarunee Vanichtanankul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes

(2012) Ruth M. Mackenzie et al.   CLINICAL SCIENCE

Metformin and the Risk of Cancer: Time-related biases in observational studies

(2012) S. Suissa et al.   DIABETES CARE

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+Antiporter

(2012) Philippa G. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Organic Cation/Carnitine Transporter 1 in Uptake of Phenformin and Inhibitory Effect on Complex I Respiration in Mitochondria

(2012) Yoshihisa Shitara et al.   TOXICOLOGICAL SCIENCES

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure

(2011) Meimei Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Solvation Effects in Protein Denaturation: From Thermodynamics to Single Molecules and Back

(2011) Jeremy L. England et al.   Annual Review of Physical Chemistry

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

(2011) Eric D. Segal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I

(2011) James A. Birrell et al.   FEBS LETTERS

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Molecular Basis of Action of a Classic Drug: Guanidine Compounds As Inhibitors of Voltage-Gated Potassium Channels

(2011) J. Kalia et al.   MOLECULAR PHARMACOLOGY

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Metformin Activates AMP Kinase through Inhibition of AMP Deaminase

(2010) Jiangyong Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The respiratory complexes I from the mitochondria of twoPichiaspecies

(2009) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Reactions of the Flavin Mononucleotide in Complex I: A Combined Mechanism Describes NADH Oxidation Coupled to the Reduction of APAD+, Ferricyanide, or Molecular Oxygen

(2009) James A. Birrell et al.   BIOCHEMISTRY

ThermoFAD, aThermofluor®-adapted flavinad hocdetection system for protein folding and ligand binding

(2009) Federico Forneris et al.   FEBS Journal

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacogenetics of antimalarial drugs: effect on metabolism and transport

(2009) Reinhold Kerb et al.   LANCET INFECTIOUS DISEASES

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Reduction of the Iron−Sulfur Clusters in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) by EuII-DTPA, a Very Low Potential Reductant†

(2008) Torsten Reda et al.   BIOCHEMISTRY

Regulation of Mitochondrial Structure and Function by the F1Fo-ATPase Inhibitor Protein, IF1

(2008) Michelangelo Campanella et al.   Cell Metabolism

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY